Before taking Avandaryl (glimepiride/rosiglitazone) 4mg/4mg, tell your doctor or pharmacist if you are allergic to rosiglitazone or glimepiride; or to other "glitazones" (e.g., pioglitazone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Promptly talk with your doctor or pharmacist about the benefits and possible risks of Avandaryl (glimepiride/rosiglitazone) 4mg/4mg, even if you have been taking it for awhile, especially if you have heart problems. Do not stop taking it unless directed to do so.
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), very high blood sugar levels (diabetic ketoacidosis), newly diagnosed or worsening heart failure (acute congestive heart failure), history of liver disease, active liver disease.
Before using Avandaryl (glimepiride/rosiglitazone) 4mg/4mg, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., chronic congestive heart failure, heart attack, angina), fluid in your lungs, swelling (edema, fluid retention), kidney disease, thyroid problems, certain hormonal conditions (adrenal/pituitary insufficiency, SIADH-syndrome of inappropriate secretion of antidiuretic hormone), mineral imbalance (hyponatremia), anemia, high blood cholesterol, eye (retina) problems, bone problems (e.g., osteoporosis, osteopenia).
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
Limit alcohol while taking Avandaryl (glimepiride/rosiglitazone) 4mg/4mg because it can increase your risk of developing low blood sugar (hypoglycemia).
During times of stress, such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar. Consult your doctor because a change in your medication may be required.
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg may increase the risk of bone fracture (upper arm, hand, foot) in female patients. To lower the chance of getting injured, use caution when doing activities such as contact sports.
Kidney function declines as you grow older. Avandaryl (glimepiride/rosiglitazone) 4mg/4mg is removed by the kidneys. Therefore, the elderly may be at greater risk for hypoglycemia while using Avandaryl (glimepiride/rosiglitazone) 4mg/4mg.
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg can cause changes in the menstrual cycle (promote ovulation) in women with certain fertility problems. Consult your doctor or pharmacist about the use of reliable birth control while taking Avandaryl (glimepiride/rosiglitazone) 4mg/4mg.
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg is not recommended for use during pregnancy. Insulin treatment may be preferred. Use of rosiglitazone/glimepiride close to the expected delivery date may increase the risk of low blood sugar in your newborn. Consult your doctor for more details and follow all instructions carefully.
It is not known whether Avandaryl (glimepiride/rosiglitazone) 4mg/4mg passes into breast milk. Therefore, breast-feeding while using Avandaryl (glimepiride/rosiglitazone) 4mg/4mg is not recommended. Consult your doctor before breast-feeding.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Read the Medication Guide provided by your pharmacist before you start taking Avandaryl (glimepiride/rosiglitazone) 4mg/4mg and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take Avandaryl (glimepiride/rosiglitazone) 4mg/4mg by mouth, usually once daily with the first meal of the day or as directed by your doctor.
The dosage is based on your medical condition and response to therapy. Do not take more than 8 milligrams of rosiglitazone/4 milligrams of glimepiride per day.
Use Avandaryl (glimepiride/rosiglitazone) 4mg/4mg regularly in order to get the most benefit from it. Remember to take it at the same time each day. Monitor your blood sugar levels on a regular basis, and share the results with your doctor.
It may take up to 2-3 months before the full benefit of Avandaryl (glimepiride/rosiglitazone) 4mg/4mg takes effect.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
See also Warning section.
Headache or sore throat may occur. If either of these effects persist or worsen, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed Avandaryl (glimepiride/rosiglitazone) 4mg/4mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Avandaryl (glimepiride/rosiglitazone) 4mg/4mg do not have serious side effects.
Tell your doctor immediately if this unlikely but serious side effect occurs: bone fracture.
Tell your doctor immediately if any of these rare but very serious side effects occur: yellowing eyes/skin, stomach/abdominal pain, persistent nausea/vomiting, dark urine, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), mental/mood changes, seizures, vision changes (e.g., color or night vision problems).
Avandaryl (glimepiride/rosiglitazone) 4mg/4mg can cause low blood sugar (hypoglycemia). This effect may occur if you do not consume enough calories (from food, juices, fruit, etc.). The symptoms include chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands/feet, and hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediately about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals.
Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medication dosage may need to be increased.
A very serious allergic reaction to Avandaryl (glimepiride/rosiglitazone) 4mg/4mg is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Click here to view a more detailed list of Avandaryl side effects.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
If you miss a dose of Avandaryl (glimepiride/rosiglitazone) 4mg/4mg, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
Before using Avandaryl (glimepiride/rosiglitazone) 4mg/4mg, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: high doses of aspirin or aspirin-like drugs (e.g., salicylates, nonsteroidal anti-inflammatory drugs - NSAIDs such as ibuprofen, phenylbutazone), azole antifungals (e.g., fluconazole, ketoconazole, miconazole), birth control pills, bupropion, chloramphenicol, clofibrate, decongestants (e.g., pseudoephedrine), diazoxide, diet pills, epinephrine, estrogens, gemfibrozil, herbal/natural products (e.g., fenugreek, ginseng, gymnema), insulin, isoniazid, MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine procarbazine, rasagiline, selegiline, isocarboxazid, tranylcypromine), niacin, nitrates (e.g., isosorbide dinitrate), phenytoin, probenecid, rifampin, sulfonamides (e.g., sulfa antibiotics), thyroid drugs, warfarin, "water pills" (diuretics such as hydrochlorothiazide, furosemide).
Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Examples include corticosteroids (such as prednisone), psychiatric medicines (such as olanzapine), fluoroquinolone antibiotics (such as ciprofloxacin), among others. Ask your doctor or pharmacist how often to check your blood sugar. Tell your doctor about the results and of any symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Beta-blocker medications (e.g., metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.
Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) which can affect your blood sugar levels. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
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IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.