Before taking Tykerb (Lapatinib) 250mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using Tykerb (Lapatinib) 250mg, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., irregular heartbeat), liver disease.
Tykerb (Lapatinib) 250mg may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Tykerb (Lapatinib) 250mg, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Tykerb (Lapatinib) 250mg safely.
Older adults may be more sensitive to the side effects of Tykerb (Lapatinib) 250mg, especially QT prolongation (see above).
Tykerb (Lapatinib) 250mg is not recommended for use during pregnancy. It may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking Tykerb (Lapatinib) 250mg. Consult your doctor for more details and to discuss the use of reliable forms of birth control (e.g., condoms, birth control pills) while taking Tykerb (Lapatinib) 250mg. If you become pregnant or think you may be pregnant, tell your doctor immediately.
It is not known whether Tykerb (Lapatinib) 250mg passes into breast milk. Because of the possible risk to the infant, breast-feeding while using Tykerb (Lapatinib) 250mg is not recommended. Consult your doctor before breast-feeding.
Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Tykerb (Lapatinib) 250mg is used together with another medication (capecitabine) to treat a certain type of breast cancer (HER2-positive) that has not responded to the standard treatment. Tykerb (Lapatinib) 250mg may also be used together with another medication (letrozole) to treat HER2-positive breast cancer in women after menopause. It works by slowing or stopping the growth of cancer cells.
Read the Patient Information Leaflet provided by your pharmacist before you start using Tykerb (Lapatinib) 250mg and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take Tykerb (Lapatinib) 250mg by mouth 1 hour before or 1 hour after a meal, usually once daily or as directed by your doctor. It is important that you do not take Tykerb (Lapatinib) 250mg more than once daily.
The dosage is based on your medical condition, response to treatment, and certain other drugs you may be taking.
Do not increase your dose or take Tykerb (Lapatinib) 250mg more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.
Avoid eating grapefruit or drinking grapefruit juice while being treated with Tykerb (Lapatinib) 250mg unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details.
Since Tykerb (Lapatinib) 250mg can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle Tykerb (Lapatinib) 250mg or breathe the dust from the tablets.
Follow your doctor's instructions on how to correctly take capecitabine or letrozole with Tykerb (Lapatinib) 250mg.
See also Warning section.
Nausea, vomiting, upset stomach, mouth sores, mild rash, dry skin, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Diarrhea is a common side effect and may become severe. Tell your doctor immediately if diarrhea occurs or if you have signs of a severe loss of body water (dehydration) such as dizziness or decreased amount of urine. Your doctor should prescribe additional medication to help control your symptoms. If your diarrhea becomes severe, your doctor may need to stop or delay your Tykerb (Lapatinib) 250mg treatment.
Treatment with Tykerb (Lapatinib) 250mg may sometimes cause your hands/feet to develop a skin reaction called hand-foot syndrome (palmar-plantar erythrodysesthesia). Tell your doctor immediately if you experience swelling, pain, redness, peeling, blisters, or tingling/burning of the hands/feet. The symptoms can be made worse by heat/pressure on your hands/feet. Avoid prolonged sun exposure, tanning booths, and sunlamps, as well as unnecessary exposure to heat (e.g., hot dishwater, long hot baths). Use a sunscreen and wear protective clothing when outdoors. Avoid pressure on elbows, knees, and soles of feet (e.g., leaning on elbows, kneeling, taking long walks). Wear loose clothing and comfortable shoes. Depending on how severe your hand-foot syndrome is, your doctor may give you an additional medication to reduce the symptoms, or stop or delay your Tykerb (Lapatinib) 250mg treatment.
Remember that your doctor has prescribed Tykerb (Lapatinib) 250mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Tykerb (Lapatinib) 250mg do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual tiredness, shortness of breath, swelling ankles/feet.
Seek immediate medical attention if any of these rare but serious side effects occur: fast/pounding/irregular heartbeat, dizziness, fainting.
A very serious allergic reaction to Tykerb (Lapatinib) 250mg is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Click here to view a more detailed list of Tykerb side effects.
For the best possible benefit, it is important to take each scheduled dose of Tykerb (Lapatinib) 250mg as directed. If you miss a dose of Tykerb (Lapatinib) 250mg, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.
Before using Tykerb (Lapatinib) 250mg, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, drugs affecting liver enzymes that remove Tykerb (Lapatinib) 250mg from your body (such as dexamethasone, cimetidine, St. John's wort, azole antifungals including itraconazole/ketoconazole, macrolide antibiotics including erythromycin/clarithromycin, HIV protease inhibitors including ritonavir/saquinavir, rifamycins including rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin).
Tykerb (Lapatinib) 250mg can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include certain "statin" cholesterol medications (simvastatin, lovastatin, atorvastatin), tacrolimus, trazodone, digoxin, and cyclosporine, among others. Tell your doctor if you also take any of these medications.
Many drugs besides Tykerb (Lapatinib) 250mg may affect the heart rhythm (QT prolongation), including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using Tykerb (Lapatinib) 250mg, report all medications you are currently using to your doctor or pharmacist.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.