Before taking Xarelto (Rivaroxaban) 20mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using Xarelto (Rivaroxaban) 20mg, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), stroke, recent major injury/surgery, blood disorders (such as anemia, hemophilia, thrombocytopenia), frequent falls/injuries, certain eye problem (retinopathy), certain hereditary enzyme problems (such as galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption).
It is important that all your doctors and dentists know that you take Xarelto (Rivaroxaban) 20mg. Before having surgery or any medical/dental procedures, tell your doctor or dentist that you are using Xarelto (Rivaroxaban) 20mg.
Xarelto (Rivaroxaban) 20mg may cause stomach bleeding. Daily use of alcohol while using this medicine will increase your risk for stomach bleeding. Limit or avoid alcoholic beverages.
Xarelto (Rivaroxaban) 20mg can cause bleeding. To lower the chance of getting cut, bruised, or injured, use great caution with sharp objects like safety razors and nail cutters. Use an electric razor when shaving and a soft toothbrush when brushing your teeth. Avoid activities such as contact sports. If you fall or injure yourself, especially if you hit your head, contact your doctor immediately. Your doctor may need to check you for hidden bleeding that could be serious.
Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, Xarelto (Rivaroxaban) 20mg should be used only when clearly needed. Discuss the risks and benefits with your doctor before using Xarelto (Rivaroxaban) 20mg.
It is unknown if Xarelto (Rivaroxaban) 20mg passes into breast milk. Consult your doctor before breast-feeding.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Use/discard the crushed tablet mixture within 4 hours. (See also How to Use section.)
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Xarelto (Rivaroxaban) 20mg is used to prevent blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip or knee replacement surgery. It is also used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and to prevent the blood clots from forming again.
Xarelto (Rivaroxaban) 20mg is an anticoagulant that works by blocking certain clotting proteins in your blood.
Read the Medication Guide provided by your pharmacist before you start taking Xarelto (Rivaroxaban) 20mg and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take Xarelto (Rivaroxaban) 20mg by mouth as directed by your doctor. If you are taking Xarelto (Rivaroxaban) 20mg to prevent blood clots after knee or hip replacement surgery, the dose is usually taken once a day. If you are taking Xarelto (Rivaroxaban) 20mg to prevent strokes and blood clots that may form due to an irregular heartbeat, the dose is usually taken once a day with the evening meal. If you are taking Xarelto (Rivaroxaban) 20mg to treat blood clots, the dose is usually taken twice a day for the first 3 weeks, and then once a day. Carefully follow your doctor's directions. Do not increase your dose, take it more often, or stop taking it unless you are told to do so by your doctor.
The 10 mg tablet may be taken with or without food. The 15 mg and 20 mg tablet should be taken with food. If you have any questions about how to take Xarelto (Rivaroxaban) 20mg, ask your doctor or pharmacist.
If you are unable to swallow whole tablets, you may crush the tablet and mix it with applesauce. Eat the entire mixture right away. Do not prepare a supply for future use. Eat some food after each dose.
If you are giving Xarelto (Rivaroxaban) 20mg through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it.
The dosage and length of treatment is based on your medical condition and response to treatment.
Use Xarelto (Rivaroxaban) 20mg regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Easy bruising or minor bleeding (such as nosebleed, bleeding from cuts) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed Xarelto (Rivaroxaban) 20mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Xarelto (Rivaroxaban) 20mg do not have serious side effects.
Xarelto (Rivaroxaban) 20mg can cause serious bleeding if it affects your blood clotting proteins too much. Tell your doctor immediately if you have any signs of serious bleeding, including: unusual pain/swelling/discomfort, unusual bruising, prolonged bleeding from cuts or gums, persistent/frequent nosebleeds, unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness/fainting, unusual or persistent tiredness/weakness, bloody/black/tarry stools, difficulty swallowing.
Get medical help right away if you have any signs of very serious bleeding, including: vision changes, confusion, slurred speech, weakness on one side of the body, changes in the amount of urine.
A very serious allergic reaction to Xarelto (Rivaroxaban) 20mg is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Click here to view a more detailed list of Xarelto side effects.
If you are taking Xarelto (Rivaroxaban) 20mg once a day and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
If you are taking Xarelto (Rivaroxaban) 20mg twice a day and miss a dose, take it as soon as you remember. If you missed the morning dose and it is near the time of the evening dose, you may take both doses together. Then resume your usual dosing schedule.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with Xarelto (Rivaroxaban) 20mg include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin, enoxaparin), certain antidepressants (including SSRIs such as fluoxetine, SNRIs such as venlafaxine).
Other medications can affect the removal of Xarelto (Rivaroxaban) 20mg from your body, which may affect how Xarelto (Rivaroxaban) 20mg works. Examples include conivaptan, certain azole antifungals (itraconazole, ketoconazole, posaconazole), rifamycins (such as rifampin), HIV protease inhibitors (such as lopinavir, ritonavir), a certain combination HIV medication (such as elvitegravir/cobicistat/emtricitabine/tenofovir), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin, phenobarbital), among others.
Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen, naproxen) that may increase your risk for bleeding if taken together with Xarelto (Rivaroxaban) 20mg. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Consult your doctor or pharmacist for more details.
Tell your doctor you are using Xarelto (Rivaroxaban) 20mg before having certain spinal procedures (spinal puncture or spinal/epidural anesthesia). Using Xarelto (Rivaroxaban) 20mg before these procedures has rarely caused major bleeding or blood clots in or around the spine. This effect may cause loss of muscle function (paralysis) that can be permanent. The risk is increased if you have a history of spinal surgery, or spinal deformity, or receive pain medication through a tube placed in the spine (epidural catheter). Also, the risk is higher if you use other "blood thinning" or anti-platelet medications such as aspirin, clopidogrel, warfarin, or nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen or naproxen. Discuss the risks and benefits of treatment with your doctor. Tell your doctor right away if you have any symptoms such as tingling, numbness (especially in the legs), or muscle weakness.
If you have a certain irregular heartbeat (atrial fibrillation), you have a higher chance of forming a blood clot in the heart that can travel to the brain and cause a stroke, or to other parts of the body. If you are taking Xarelto (Rivaroxaban) 20mg to prevent these harmful blood clots and have to stop taking it, you may have a higher risk of forming a blood clot. Your doctor may direct you to take a different "blood thinning" or anti-platelet medication to reduce your risk. Get medical help right away if you have any of the following symptoms: weakness on one side of the body, slurred speech, sudden vision changes, or confusion.