Before taking capecitabine, tell your doctor or pharmacist if you are allergic to it; or to 5-fluorouracil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Xeloda (capecitabine ) 150mg should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease, a certain enzyme deficiency (dihydropyrimidine dehydrogenase deficiency).
Before using Xeloda (capecitabine ) 150mg, tell your doctor or pharmacist your medical history, especially of: blood disorders (e.g., bone marrow suppression), heart problems (e.g., coronary artery disease, heart failure), kidney problems, liver problems.
Wash your hands well to prevent the spread of infections.
Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine.
Xeloda (capecitabine ) 150mg may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use an effective sunscreen and wear protective clothing when outdoors. This will also help protect you from problems related to heat (hand/foot syndrome). See Side Effects section for more information.
To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports. Use a soft-bristle toothbrush to lower the risk of bleeding gums.
Caution is advised when Xeloda (capecitabine ) 150mg is used in the elderly because they may be more sensitive to the side effects of Xeloda (capecitabine ) 150mg, especially nausea, vomiting, and diarrhea.
Xeloda (capecitabine ) 150mg is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details and to discuss reliable forms of birth control. It is recommended that men and women use two effective forms of birth control (e.g., condoms and birth control pills) while taking Xeloda (capecitabine ) 150mg.
It is not known if Xeloda (capecitabine ) 150mg passes into breast milk. Because of possible harm to the nursing infant, breast-feeding while using Xeloda (capecitabine ) 150mg is not recommended. Consult your doctor before breast-feeding.
Store at room temperature at 77 degrees F (25 degrees C) in a tightly closed container away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Read the Patient Information Leaflet provided by your pharmacist before you start taking Xeloda (capecitabine ) 150mgand each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.
Take Xeloda (capecitabine ) 150mg by mouth, usually twice daily in the morning and evening or as directed by your doctor. It is best to take this with a full glass of water (8 ounces or 240 milliliters) within 30 minutes after the end of a meal. Xeloda (capecitabine ) 150mgis usually taken every day for 2 weeks, then stopped for 1 week. This course of treatment may be repeated as directed by your doctor.
If you take any antacid products that contain aluminum or magnesium, take Xeloda (capecitabine ) 150mg2 hours before or after taking any antacids because these products may change the way your body absorbs capecitabine.
The dosage is based on your medical condition, body size, and response to therapy. You may be taking a combination of different tablet sizes. Pay close attention to your dose and tablet sizes to avoid over- or under-dosing.
Do not increase your dose or take Xeloda (capecitabine ) 150mg more often than directed without your doctor's approval. Your condition will not improve any faster, and the risk of serious side effects may increase.
Since Xeloda (capecitabine ) 150mg can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle Xeloda (capecitabine ) 150mg.
Nausea, vomiting, loss of appetite, constipation, tiredness, weakness, back/joint/muscle pain, headache, dizziness, trouble sleeping, skin darkening, or dry/itchy skin may occur. Nausea and vomiting can be severe. Changes in diet and lifestyle, such as eating several small meals or limiting activity, may lessen some of these effects. If any of these effects continue or worsen, notify your doctor.
Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Temporary nail changes may occur, which may rarely include fungal infections in the nail beds.
Remember that your doctor has prescribed Xeloda (capecitabine ) 150mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Xeloda (capecitabine ) 150mg do not have serious side effects.
Diarrhea is a common side effect of Xeloda (capecitabine ) 150mg. It may become very severe (possibly fatal). To decrease this side effect, your doctor may prescribe medication (e.g., loperamide) to control your symptoms, replace lost fluids by vein, or stop treatment with capecitabine. Drink plenty of fluids to prevent serious problems due to a loss of too much body water (dehydration). If you experience signs of severe diarrhea (e.g., 4 or more stools per day, diarrhea at night, bloody stools), or if you experience signs of dehydration (e.g., dizziness, decreased amount of urine), stop taking Xeloda (capecitabine ) 150mg and tell your doctor immediately.
Stop taking Xeloda (capecitabine ) 150mgand tell your doctor immediately if you have any of these serious side effects: severe nausea/vomiting (vomiting 2 or more times per day, inability to eat or keep food/fluids in your stomach), painful redness/swelling/sores in mouth or throat.
If any of the above symptoms occur, your doctor may lower your dose when you start taking Xeloda (capecitabine ) 150mgagain or may stop treatment with Xeloda (capecitabine ) 150mg.
Treatment with Xeloda (capecitabine ) 150mgmay sometimes cause your hands/feet to develop a skin reaction called hand-foot syndrome (palmar-plantar erythrodysesthesia). You can prevent or reduce these problems by protecting your hands and feet from a great deal of heat or pressure. Avoid unnecessary exposure to heat (e.g., hot dishwater, long hot baths). Avoid pressure on elbows, knees, and soles of feet (e.g., leaning on elbows, kneeling, long walks). Wear loose clothing. Depending on how severe your hand-foot syndrome is, your doctor may prescribe a medication to reduce the symptoms or decrease/delay your next dose of capecitabine. If you experience pain/swelling/redness, blisters, or numbness of the hands/feet that affects your usual activities, stop taking Xeloda (capecitabine ) 150mg and tell your doctor immediately.
Xeloda (capecitabine ) 150mg can lower your ability to fight an infection. Stop taking Xeloda (capecitabine ) 150mg and call your doctor promptly if you develop any signs of an infection such as high fever, chills, or persistent sore throat.
Tell your doctor immediately if you have any of these unlikely but serious side effects: abdominal/stomach pain, unusual bruising or bleeding, extreme tiredness, mental/mood changes (e.g., depression), swelling of the ankles/feet, vision changes, shortness of breath, change in the amount of urine, dark urine, yellowing of the eyes/skin, fast/irregular heartbeat.
Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, fainting, jaw/left arm pain.
A very serious allergic reaction to Xeloda (capecitabine ) 150mg is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other side effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Click here to view a more detailed list of Xeloda side effects.
If you miss a dose of Xeloda (capecitabine ) 150mg, do not take the missed dose and do not double the next dose. Continue your regular dosing schedule and check with your doctor.
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.
Before using Xeloda (capecitabine ) 150mg, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: folic acid (including multivitamins with folic acid), leucovorin, metronidazole, tinidazole.
Xeloda (capecitabine ) 150mg can change the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include: "blood thinners" (e.g., warfarin), fosphenytoin, phenytoin.
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting capecitabine.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.