Before taking this product, tell your doctor or pharmacist if you are allergic to lisinopril or hydrochlorothiazide; or to other ACE inhibitors (such as captopril, benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using Zestoretic (Lisinopril/HCTZ) 10/12.5mg, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction that included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), desensitizing treatment for bee/wasp sting allergy, gout, kidney disease, liver disease, collagen vascular disease (such as lupus, scleroderma).
Zestoretic (Lisinopril/HCTZ) 10/12.5mg may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.
Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.
If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Zestoretic (Lisinopril/HCTZ) 10/12.5mg may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
This product may affect your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of Zestoretic (Lisinopril/HCTZ) 10/12.5mg, especially dizziness and unusual change in the amount of urine (kidney problems).
Zestoretic (Lisinopril/HCTZ) 10/12.5mg is not recommended for use during pregnancy due to the risk for harm to an unborn baby. Consult your doctor for more details. (See also Warning section.)
It is unknown if lisinopril passes into breast milk. Hydrochlorothiazide passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Zestoretic (Lisinopril/HCTZ) 10/12.5mg is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
This product is used when one drug is not controlling your blood pressure. Your doctor may direct you to take the individual medications first, and then switch you to this combination product. Do not continue taking the individual medications (lisinopril and/or hydrochlorothiazide) after you start Zestoretic (Lisinopril/HCTZ) 10/12.5mg.
Take Zestoretic (Lisinopril/HCTZ) 10/12.5mg by mouth as directed by your doctor, usually once daily in the morning with or without food. If Zestoretic (Lisinopril/HCTZ) 10/12.5mg causes you to urinate more frequently, it is best to take it at least 4 hours before your bedtime to prevent having to get up to urinate.
If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take lisinopril/hydrochlorothiazide at least 4 hours before or at least 4 to 6 hours after these medications.
The dosage is based on your medical condition and response to treatment.
Use Zestoretic (Lisinopril/HCTZ) 10/12.5mg regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking Zestoretic (Lisinopril/HCTZ) 10/12.5mg even if you feel well. Most people with high blood pressure do not feel sick.
Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).
Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed Zestoretic (Lisinopril/HCTZ) 10/12.5mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Zestoretic (Lisinopril/HCTZ) 10/12.5mg do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), signs of infection (such as fever, chills, persistent sore throat), unusual change in the amount of urine (not including the normal increase in urine when you first start Zestoretic (Lisinopril/HCTZ) 10/12.5mg).
This product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps/weakness, fast/slow/irregular heartbeat, confusion, decreased urination.
Zestoretic (Lisinopril/HCTZ) 10/12.5mg may rarely cause serious (possibly fatal) liver problems. Tell your doctor right away if you notice any of these rare but serious side effects: dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, decrease in vision, eye pain.
A very serious allergic reaction to Zestoretic (Lisinopril/HCTZ) 10/12.5mg is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Click here to view a more detailed list of Zestoretic side effects.
If you miss a dose of Zestoretic (Lisinopril/HCTZ) 10/12.5mg, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
See also How to Use and Precautions sections.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with Zestoretic (Lisinopril/HCTZ) 10/12.5mg include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as birth control pills containing drospirenone).
Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure or worsen your heart failure. Ask your pharmacist for more details.
Zestoretic (Lisinopril/HCTZ) 10/12.5mg may interfere with certain laboratory tests (including parathyroid function), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Zestoretic (Lisinopril/HCTZ) 10/12.5mg.