Before taking this product, tell your doctor or pharmacist if you are allergic to either lisinopril or hydrochlorothiazide; or to other ACE inhibitors (e.g., captopril, benazepril); or to other thiazides (e.g., chlorothiazide); or if you have any other allergies.
Zestoretic (lisinopril/hctz) should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of an allergic reaction that included swelling of the face/lips/tongue/throat (angioedema), an inability to make urine (anuria).
Before using Zestoretic (lisinopril/hctz), tell your doctor or pharmacist your medical history, especially of: kidney disease (e.g., renal artery stenosis), liver disease, heart/blood vessel problems (e.g., heart failure, aortic stenosis, coronary artery disease, stroke), blood exchange procedures (e.g., apheresis, dialysis), high cholesterol/triglycerides, loss of too much body water (dehydration), untreated mineral imbalance (e.g., high calcium, high/low potassium, low magnesium), diabetes, gout, collagen vascular disease (e.g., lupus, scleroderma).
Zestoretic (lisinopril/hctz) may make you dizzy. Use caution while driving, using machinery, or doing any activity that requires alertness. Limit alcoholic beverages.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Before having surgery, tell your doctor or dentist that you are taking Zestoretic (lisinopril/hctz).
Drink plenty of fluids while taking Zestoretic (lisinopril/hctz) to help prevent dizziness unless directed otherwise by your doctor. Too much sweating, diarrhea, or vomiting may cause you to feel lightheaded. Report prolonged diarrhea or vomiting to your doctor.
Zestoretic (lisinopril/hctz) may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
This product may increase or decrease your potassium levels. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist.
If you have diabetes, this product may change your blood sugar levels. Check your blood glucose levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst and urination, or signs of low blood sugar such as nervousness, hunger, and shaking. Your anti-diabetic medication or diet may need to be adjusted.
Kidney function declines as you grow older. Zestoretic (lisinopril/hctz) is removed by the kidneys. Therefore, elderly people may be at greater risk for dizziness while using Zestoretic (lisinopril/hctz).
Zestoretic (lisinopril/hctz) is not recommended for use during pregnancy due to the risk for harm to an unborn baby. Consult your doctor for more details. (See also Warning section.)
Hydrochlorothiazide passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using Zestoretic (lisinopril/hctz) is not recommended. Consult your doctor before breast-feeding.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Take Zestoretic (lisinopril/hctz) by mouth with or without food, usually once daily or as directed by your doctor. If Zestoretic (lisinopril/hctz) causes you to urinate more frequently, then it is best to take Zestoretic (lisinopril/hctz) in the morning or during the day (at least 4 hours before your bedtime) to avoid having to get up during the night to urinate. Consult your doctor or pharmacist if you have questions about your dosing schedule.
The dosage is based on your medical condition and response to treatment.
Use Zestoretic (lisinopril/hctz) regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. Also, keep your doses in a special pill box with 1 space marked for each day of the week. It is important to continue taking Zestoretic (lisinopril/hctz) even if you feel well. Most people with high blood pressure do not feel sick.
Do not stop taking Zestoretic (lisinopril/hctz) without first consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased.
For the treatment of high blood pressure, it may take 2 to 4 weeks before the full benefit of Zestoretic (lisinopril/hctz) occurs. It may take several weeks or months to see the full benefit when Zestoretic (lisinopril/hctz) is used for heart failure.
Tell your doctor if your condition worsens (e.g., your routine blood pressure readings increase).
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed Zestoretic (lisinopril/hctz) because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Zestoretic (lisinopril/hctz) do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: extreme thirst, very dry mouth, muscle cramps/weakness, swelling of the hands/feet, fast/slow/irregular heartbeat, fainting, muscle/joint aches, tingling/numbness of the hands/feet.
Tell your doctor immediately if any of these rare but very serious side effects occur: signs of infection (e.g., fever, chills, persistent sore throat), yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent tiredness, persistent nausea/vomiting, easy bruising/bleeding, unusual change in the amount of urine (not including the normal increase in urine when you first start Zestoretic (lisinopril/hctz)), seizures.
A very serious allergic reaction to Zestoretic (lisinopril/hctz) is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling (especially of the face, lips, tongue, or throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Click HERE to learn more about Zestoretic side effects.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
If you miss a dose of Zestoretic (lisinopril/hctz), take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
See also Precautions section.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.
Zestoretic (lisinopril/hctz) should not be used with the following medication because very serious interactions may occur: dofetilide.
If you are currently using the medication listed above, tell your doctor or pharmacist before starting this product.
Before using Zestoretic (lisinopril/hctz), tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: alpha blockers (e.g., prazosin, terazosin), aspirin, cisapride, diazoxide, digoxin, drugs that may affect the bone marrow (e.g., azathioprine, trimethoprim-containing products), drugs for diabetes (e.g., insulin, glipizide), drugs that can increase dizziness (e.g., narcotic pain relievers such as morphine, barbiturates such as phenobarbital), drugs that may decrease your potassium level (e.g., amphotericin B, corticotropin, corticosteroids including prednisone), drugs that may increase your potassium level (e.g., potassium-sparing diuretics such as spironolactone, potassium supplements, salt substitutes), drugs whose removal from the body is affected by the acid level of urine (e.g., amphetamine, methenamine, quinidine), lithium, nonsteroidal anti-inflammatory drugs-NSAIDs (e.g., celecoxib, ibuprofen, indomethacin), other drugs for high blood pressure (e.g., beta blockers, calcium channel blockers), probenecid.
A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking lisinopril/hydrochlorothiazide. Make sure all your doctors know which medicines you are using.
If taken together with Zestoretic (lisinopril/hctz), cholestyramine and colestipol can decrease the amount of Zestoretic (lisinopril/hctz) that is absorbed by your body. If you are taking either of these drugs, separate them from Zestoretic (lisinopril/hctz) by at least 4 hours.
Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure (e.g., decongestants such as pseudoephedrine, phenylephrine) or reduce the effect of Zestoretic (lisinopril/hctz) (e.g., ibuprofen, naproxen). Ask your pharmacist about using these products safely.
Some nonprescription medicines may also contain aspirin, which may decrease the effect of the lisinopril in this product. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.
This product can affect the results of certain lab tests (e.g., parathyroid, protein-bound iodide, tyramine and phentolamine tests). Make sure laboratory personnel and all your doctors know you use Zestoretic (lisinopril/hctz).
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
IMPORTANT NOTE: The preceding information is intended to heighten awareness of health information and does not suggest diagnosis or treatment. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.