Archive for June, 2010

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A common drug interaction is putting elderly patients in the hospital: ICES study

Wednesday, June 30th, 2010

Two commonly used drugs are dangerous when prescribed together
A study performed at the Institute for Clinical Evaluative Sciences (ICES) found that the commonly used antibiotic trimethoprim-sulfamethoxazole (TMP-SMX) is associated with a nearly 7-fold increased risk of hospitalization for hyperkalemia (abnormally high potassium levels in the blood) in elderly patients being treated with angiotensin converting enzyme inhibitors (ACEIs) [...]

Compliance with statin therapy cuts hospitalization, costs

Wednesday, June 30th, 2010

Treatment compliance in the first 2 years of statin therapy is associated with reduced hospitalization rates and medical costs, a US study indicates.
In a real-world group of statin users, treatment compliance at levels of 80% or above predicted better clinical and economic outcomes, leading the researchers to endorse “focusing compliance efforts on patients who are [...]

Exenatide extended-release shows good safety profile for Type 2 diabetes

Wednesday, June 30th, 2010

Source: MedWire News
Exenatide provided once a week as an extended-release injectable suspension appears to be as well tolerated as the currently available twice-daily exenatide, and may even provide better tolerability due to a lower incidence of gastrointestinal (GI) events and low rate of nausea, study findings show.
The findings have emerged from a pooled analysis of [...]

IUDs more effective at preventing pregnancy than hormonal injection

Monday, June 28th, 2010

Source: MedWire News
Intrauterine devices (IUDs) better protect women against the risk for pregnancy compared with depot progestogens (DMPA), show the results of a two-study review.
“This information will be useful for counseling women regarding their choice of contraception,” write G Justus Hofmeyr from the University of the Witwatersrand in East London, South Africa, and colleagues.
The team [...]

Saxagliptin plus metformin superior to monotherapy for Type 2 diabetes

Monday, June 28th, 2010

Giving patients with Type 2 diabetes a combination of the selective dipeptidyl peptidase-4 inhibitor saxagliptin (Brand Name: Onglyza) and metformin early, rather than waiting until one drug fails, gives superior long-term glycemic improvements compared with either monotherapy alone, research suggests.
Andreas Pfützner, from the Institute for Clinical Research and Development in Mainz, Germany, who presented the findings [...]

Intensive statin therapy stabilizes coronary plaques

Friday, June 25th, 2010

Source: MedWire News
The composition and burden of non-calcified coronary atherosclerotic lesions (NCALs) is influenced by statin therapy, study findings suggest.
The researchers say that intensive statin therapy not only reduces the number of lipid-rich coronary plaques, but also inhibits potentially deleterious changes in vulnerable plaques.
Hideya Yamamoto (Hiroshima University Graduate School of Biomedical Sciences, Japan) and colleagues [...]

Dietary factors may protect against psychotic-like symptoms

Friday, June 25th, 2010

Source: MedWire News
Women with a high intake of fish, omega-3 or omega-6 polyunsaturated fatty acids, and vitamin D may have a lower risk for psychotic-like symptoms, suggests research.
“The biological mechanisms underlying the etiology of schizophrenia and psychotic symptoms are largely unknown. Genetic constitution is important, but environmental factors like an unhealthy lifestyle with a poor [...]

Antiretroviral Therapy Treatment May Reduce Perinatal AIDS Transmission.

Wednesday, June 23rd, 2010

Bloomberg News (6/17, Randall) reports that, according to studies published June 17 in the New England Journal of Medicine, “AIDS transmission to babies was blocked in 99 percent of cases when breastfeeding mothers infected with the HIV virus took triple-drug combinations.” In fact, one study in Botswana of 730 pregnant women [...]

Long-term trial results support intensive lipid control

Wednesday, June 23rd, 2010

Source: MedWire News
The longest follow-up of a lipid-atherosclerosis intervention trial to date supports the longevity benefits of intensive intervention to control lipid levels, say researchers.
Twenty-five-year results from the Program on the Surgical Control of the Hyperlipidemias (POSCH) trial showed gains in survival, both overall and free from cardiovascular disease, and life expectancy with surgery to [...]

When Food and Pills Clash

Wednesday, June 23rd, 2010

Source: Wall Street Journal
Fresh Concerns on How Diet and Medicines Interact, From Pepper to Pomegranate
Americans increasingly view the food they eat as medicine to help lower cholesterol, reduce high blood pressure and control blood sugar. But as with prescribed drugs, the health-improving qualities of foods such as olive oil, nuts and fruit can interact with [...]

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