Cholesterol
« Previous Entries Next Entries »Blood glucose promotes lipoprotein(a) oxidization
Wednesday, September 29th, 2010Source: MedWire News
Blood glucose levels influence the oxidization of lipoprotein(a), a molecule with potent atherosclerotic properties, research has found.
The study was undertaken by Kazuhiko Kotani (Jichi Medical University, Tochigi, Japan) and co-workers and aimed to investigate the association between circulating levels of oxidized Lp(a) [oxLp(a)] and cardiometabolic variables.
The study participants were 70 healthy women with [...]
Fenofibrate, niacin ‘largely comparable’ in atherogenic dyslipidemia
Tuesday, September 14th, 2010Source: MedWire News
Fenofibrate and niacin are “largely comparable” as treatments for patients with hypertriglyceridemia and low levels of high-density lipoprotein (HDL) cholesterol, a randomized trial has found.
However, the two treatments had different effects on glucose metabolism and inflammation, leading the authors to recommend an individualized approach to the pharmacologic treatment of atherogenic dyslipidemia.
A team led [...]
Fenofibrate added to pravastatin could help control mixed hyperlipidemia
Friday, September 3rd, 2010Source: MedWire News
Adding 160 mg fenofibrate daily to 40 mg pravastatin can significantly improve the lipid profile of high-risk patients whose mixed hyperlipidemia is not controlled by the statin alone, trial findings suggest.
Combination therapy resulted in significantly greater decrease in the primary endpoint of non-high-density lipoprotein (non-HDL) cholesterol compared with 40-mg pravastatin monotherapy.
Significantly more patients [...]
Anti-inflammatory effects of HDL revealed
Thursday, August 19th, 2010High-density lipoprotein (HDL) particles interfere with the binding of T-cell microparticles (MPs) to human monocytes, new research suggests.
The net result is to inhibit the production of pro-inflammatory cytokines, meaning this is one mechanism by which HDL cholesterol exerts an anti-inflammatory effect.
The findings are reported by an Italian team in the open-access journal PLoS One.
Rakel Carpintero (University [...]
Low HDL, high triglycerides contribute to residual CHD risk
Tuesday, August 17th, 2010Source: MedWire News
High levels of triglycerides and low levels of high-density lipoprotein (HDL) cholesterol have a “strong and synergistic” influence on coronary heart disease (CHD) risk in the presence of well-controlled low-density lipoprotein (LDL) cholesterol, US scientists believe.
Vincent Carey (Brigham and Women’s Hospital, Boston, Massachusetts) and colleagues sought to quantify the relative contributions of triglycerides [...]
Suboptimal cholesterol levels in young people have long-term repercussions
Monday, August 16th, 2010Young people with suboptimal cholesterol levels are at increased risk for developing coronary atherosclerosis many years later, suggests a study published in the Annals of Internal Medicine.
Levels of low- and high-density lipoprotein (LDL and HDL) cholesterol in adults aged 18 to 30 years - who were neither taking lipid-lowering medication nor had clinically abnormal concentrations - [...]
HMG-CoA reductase enzyme could add to plaque instability
Tuesday, August 3rd, 2010Source: MedWire News
South-Korean researchers have discovered that hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase may contribute to coronary artery plaque instability, which could help to explain some early benefits of statin therapy.
They found HMG-CoA reductase in coronary atherosclerotic plaques, and showed that levels were greater in plaques that were unstable. Immunohistochemical staining revealed that cells immunopositive for [...]
Ezetimibe reduces ox-LDL levels
Friday, July 9th, 2010Source: MedWire News
Adding ezetimibe to atorvastatin decreases levels of oxidized low-density lipoprotein (ox-LDL) cholesterol in patients with coronary heart disease (CAD) or an equivalent condition, research shows.
“Ox-LDL level correlates with the vulnerability of atherosclerotic lesions,” say Rabih Azar and colleagues from Hôtel Dieu de France Hospital in Beirut, Lebanon.
“Reduction of ox-LDL level by ezetimibe therapy [...]
Even small amounts of exercise improve lipid profiles in youth
Tuesday, June 22nd, 2010Source: MedWire News
There is a dose-response relationship between physical activity and dyslipidemia in young people, Canadian researchers have discovered.
Their data underline the cardiovascular benefits associated with engaging in moderate-to-vigorous physical activity (MVPA), even at levels below the current target of 60 minutes per day.
“Lower MVPA targets may act as an incentive for currently sedentary youth,” [...]
Long-term weight loss confers favorable lipid changes
Monday, June 7th, 2010Source: MedWire News
Women who maintain a reduction in abdominal fat following weight-loss intervention show beneficial changes in their blood lipid profile, a Japanese study suggests.
The authors say that long-term weight maintenance following short-term weight loss should therefore “be encouraged for obese people.”
The study, by T Matsuo (University of Tsukuba, Ibaraki) and team, involved 54 postmenopausal [...]
