Clopidogrel
Rebound effect ‘unlikely’ after post-TIA clopidogrel
Monday, June 14th, 2010Source: MedWire News
Physicians need not fear rebound events in patients completing a short course of clopidogrel following a transient ischemic attack (TIA) or minor stroke, research suggests.
Several studies have noted a two-to-three-fold increased risk for myocardial infarction or death during the first 90 days after stopping clopidogrel in patients with acute coronary syndromes (ACS).
There are [...]
Plavix May Reduce Death Risk In Patients With Certain Heart Conditions.
Tuesday, March 23rd, 2010HealthDay (3/22, Preidt) reported that “Plavix [clopidogrel] is of modest benefit in cutting the odds of death in patients with heart failure and heart attack who don’t undergo angioplasty,” according to a study published in the Journal of the American College of Cardiology. In the study, “there were 812 deaths (32.2 [...]
Double dose of Plavix better for certain angioplasty patients
Tuesday, September 29th, 2009HealthDay (9/28, Edelson) reported that “cardiologists are looking at the next generation of clot-busters that could replace Plavix [clopidogrel].” In a study “published in the Oct. 6 issue of the Journal of the American College of Cardiology,” researchers “found that a 600-milligram dose of Plavix is more effective than a 300-milligram [...]
Research suggests high dose of atorvastatin prior to PCI may benefit chronic statin users.
Friday, July 3rd, 2009MedPage Today (7/1, Neale) reported that “patients on chronic statin therapy who re-loaded with high-dose atorvastatin (Lipitor) before percutaneous coronary intervention showed improved clinical outcomes in a randomized trial,” the findings of which were published online in the Journal of the American College of Cardiology. Since “most patients who show up in the cath lab [...]
Research suggests adding Plavix to aspirin may reduce heart risks in atrial fibrillation patients.
Wednesday, April 1st, 2009The Wall Street Journal (4/1, D5, Loftus) reports that “adding the anticlotting drug Plavix [clopidogrel] to aspirin in people with” atrial fibrillation “modestly reduced the combined risk of strokes and related disease versus aspirin alone,” according to a study presented at the American College of Cardiology conference and published online in the New England Journal [...]
Pantoprazole: preferred PPI in patients taking clopidogrel
Thursday, February 5th, 2009A new Canadian Medical Association Journal (CMAJ) study suggests that the interaction between clopidogrel and proton pump inhibitors (PPIs) is clinically significant. The population-based case-control study included more than 13,500 patients (age 66 years or older) who were prescribed clopidogrel following hospital discharge after an acute myocardial infarction. Patients who also received a PPI (other [...]
US FDA seeks more data on bloodthinner PlavixUS FDA seeks more data on bloodthinner Plavix
Tuesday, January 27th, 2009US FDA seeks more data on bloodthinner Plavix
U.S. health regulators are reviewing the effectiveness in some patients of the widely used blood thinner Plavix, made by Sanofi-Aventis SA and Bristol-Myers Squibb Co.
The move comes after several studies found the blockbuster drug did not work as well in certain people possibly because patients metabolized it differently depending [...]
