Statins
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Wednesday, August 4th, 2010Source: MedWire News
Statin therapy may stabilize vulnerable atherosclerotic plaque by decreasing total atheroma volume and increasing fibrous cap thickness, a study suggests.
Reductions in total atheroma volume were associated with decreases in the ratio of low- to high-density lipoprotein (LDL/HDL) cholesterol, whereas a reduction in corresponding fibrous cap thickness was related to lowered levels of high-sensitivity [...]
HMG-CoA reductase enzyme could add to plaque instability
Tuesday, August 3rd, 2010Source: MedWire News
South-Korean researchers have discovered that hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase may contribute to coronary artery plaque instability, which could help to explain some early benefits of statin therapy.
They found HMG-CoA reductase in coronary atherosclerotic plaques, and showed that levels were greater in plaques that were unstable. Immunohistochemical staining revealed that cells immunopositive for [...]
Statin users may be less likely to experience prostate cancer recurrence
Wednesday, July 14th, 2010Source: MedWire News
Prostate cancer patients treated with radical prostatectomy (RP) may be less likely to experience disease recurrence after surgery if they use certain cholesterol-lowering drugs, report US researchers.
The study results show that men who took statins had a 30% reduced risk for biochemical recurrence after surgery compared with those who did not.
Stephen Freedland from [...]
Compliance with statin therapy cuts hospitalization, costs
Tuesday, June 29th, 2010Treatment compliance in the first 2 years of statin therapy is associated with reduced hospitalization rates and medical costs, a US study indicates.
In a real-world group of statin users, treatment compliance at levels of 80% or above predicted better clinical and economic outcomes, leading the researchers to endorse “focusing compliance efforts on patients who are [...]
Intensive statin therapy ‘stabilizes coronary plaques’
Friday, June 25th, 2010Source: MedWire News
The composition and burden of non-calcified coronary atherosclerotic lesions (NCALs) is influenced by statin therapy, study findings suggest.
The researchers say that intensive statin therapy not only reduces the number of lipid-rich coronary plaques, but also inhibits potentially deleterious changes in vulnerable plaques.
Hideya Yamamoto (Hiroshima University Graduate School of Biomedical Sciences, Japan) and colleagues [...]
Statins show potent anti-ischemic effect in stable angina
Friday, June 4th, 2010Source: MedWire News
Statins could exert anti-ischemic effects in patients with chronic stable angina that are as potent as those of the calcium-channel blocker amlodipine, trial findings suggest.
Atorvastatin virtually eliminated episodes of transient myocardial ischemia (TMI) from the daily life of participants in the Double-blind Atorvastatin and Amlodipine (DUAAL) trial.
Interestingly, TMI changes did not appear to [...]
Statins linked with reduced AF incidence in CAD patients
Tuesday, May 4th, 2010Source: MedWire News
Statin therapy is associated with a reduced risk for new-onset atrial fibrillation (AF) in patients who have been hospitalized for coronary artery disease (CAD), a large cohort study suggests.
In the study of nearly 30,000 Medicare beneficiaries, statin use was independently associated with a lower risk for AF, supporting a potential anti-arrhythmic effect of [...]
Statin Treatment Linked To Lower Cardiovascular Mortality In Very Elderly Patients After MI.
Friday, April 2nd, 2010Medscape (4/1, Barclay) reported that “statin treatment is linked to lower cardiovascular mortality rates in very elderly patients after myocardial infarction, but without an increased risk for cancer mortality,” according to research published in the Journal of the American College of Cardiology. According to the study’s authors, “These observations suggest that [...]
Statins may reduce risk for renal dysfunction in Type 2 diabetes
Sunday, March 21st, 2010Use of statins reduces the risk for renal dysfunction in individuals with Type 2 diabetes, report researchers.
“Amongst all diabetes-associated complications, diabetic nephropathy has probably the most detrimental consequences resulting in dialysis and heightened cardiovascular risks,” say Ronald Ma (The Chinese University of Hong Kong, China) and colleagues.
As high cholesterol has been associated with increased risk [...]
Statins May Significantly Reduce Prostate Tumor Inflammation.
Tuesday, February 23rd, 2010HealthDay (2/22, Preidt) reported that “cholesterol-lowering statins significantly reduce prostate tumor inflammation, which may help lower the risk of disease progression,” according to a study published online in the journal Cancer Epidemiology, Biomarkers & Prevention. Investigators “examined tissue samples of prostate tumors from 236 men undergoing prostate cancer surgery.” The [...]
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