« | Home | »

HDL cholesterol an important factor in heart disease risk

By jeremyc | May 27, 2015

A University of Pennsylvania study has found that the function of a patient’s high-density lipoprotein (HDL) cholesterol may important in considering heart disease risk. Patients with high HDL function were found to have suffered from fewer heart disease problems and heart attacks over the years.

The study was led by Daniel Rader, director of the Preventive Cardiovascular Medicine and Lipid Clinic at Penn Medicine, who said, “This is a definitive finding that HDL function, even in people who are still relatively young and healthy, does predict later heart disease events, which implies that therapies that boost HDL function might reduce risk.”

For this study, the researchers looked at frozen blood samples of over 25,000 women and men in eastern England. The study took place from 1993 to 2009. Of the participants, 1,745 eventually developed heart disease. The blood samples of these patients were compared to those of a control group of people who did not develop heart disease.

On analysis, the researchers found that the patients who had good HDL function had a 36 percent less heart attacks than those who had poor HDL function.

Rader said, “We don’t fully understand why people differ in their HDL cholesterol [efficiency], but we have known for some time that the size, lipid content, and protein cargo of HDL particles can vary, and there is also some evidence for functional impairment of HDLs in heart disease and diabetes. I think we now have a convincing story that HDL’s ability to promote cholesterol [efficiency] is predictive of future heart disease events even when measured early in a healthy person’s life.”

Topics: | Heart | No Comments »

Comments are closed.