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Norvir and Lopinavir Combo Good for Children

By jeremyc | July 8, 2013

According to a recent study, a low dose treatment of ritonavir (brand name Norvir) and lopinavir may be safe and effective for children diagnosed with HIV. It has a similar efficiency of standard doses given to children with fewer adverse effects, according to the researchers.

The intention-to-treat analysis involved 101 children on the low dose regimen. Around 88 percent of them achieved undetectable viral loads, as compared to the 90-98 children who were treated with the standard dose. The study was conducted by Thanyawee Puthanakit, MD, and colleagues from the Chulalongkorn University, Bangkok.

Dr. Puthanakit says about the study, “This study demonstrated non-inferiority in virologic efficacy of low dose compared to standard dose lopinavir/ritonavir tablets as maintenance therapy.” As for adverse effects, the study showed that children on the low dose treatment had much lower cholesterol levels. Around 34 percent of the children taking the standard dose had more than 200mg/dl of cholesterol by the end of the 48-week trial. In comparison, only 20 percent of the children on the low dose regimen had a cholesterol reading that high.

The researchers added, “This dosing regimen conferred adequate lopinavir blood level with reduced drug cost, and reduced potential long-term complications such as dyslipidemia. Lopinavir/ritonavir is the most commonly used HIV regimen used in children.”

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