Invega Sustenna 156mg/mL(Paliperidone Palmitate)
Please Note: Invega Sustenna 78mg is marketed as Xeplion and is listed as 50mg in the UK. The US product is measured as 78mg Paliperidone Palmitate while the UK product is measured as 50mg Paliperidone.
Please Note: Invega Sustenna 117mg is marketed as Xeplion and is listed as 75mg in the UK. The US product is measured as 117mg Paliperidone Palmitate while the UK product is measured as 75mg Paliperidone.
Please Note: Invega Sustenna 156mg is marketed as Xeplion and is listed as 100mg in the UK. The US product is measured as 156mg Paliperidone Palmitate while the UK product is measured as 100mg Paliperidone.
Please Note: Invega Sustenna 234mg is listed as 150mg in Canada. The US product is measured as 234mg Paliperidone Palmitate while the Canadian product is measured as 150mg Paliperidone.
Marketed as Xeplion Pre-Filled Syringe 150mg/1.5mL in United Kingdom
Invega Sustenna Drug Information
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Invega Sustenna Overview
Invega Sustenna 156mg/mL is used to treat certain mental/mood disorders (such as schizophrenia, schizoaffective disorder). Paliperidone is an antipsychotic drug (atypical type). It works by helping to restore the balance of certain natural chemicals (neurotransmitters) in the brain. Invega Sustenna 156mg/mL can decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life.
Invega Sustenna Warnings
There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when Invega Sustenna 156mg/mL is used by older adults with dementia. Invega Sustenna 156mg/mL is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of Invega Sustenna 156mg/mL, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
How to Use Invega Sustenna
Read the Patient Information Leaflet provided by your pharmacist before you start using paliperidone and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Invega Sustenna 156mg/mL is given by injection into a muscle (upper arm or buttocks) by a health care professional. The first 2 doses are usually given 1 week apart, in the upper arm. After the first 2 doses, the medication is usually given into the upper arm or buttocks every month or as directed by your doctor. Dosage of Invega Sustenna 156mg/mL is based on your medical condition and response to treatment. Use Invega Sustenna 156mg/mL regularly in order to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication. Continue using Invega Sustenna 156mg/mL exactly as prescribed, even if you are feeling better and thinking more clearly. Do not stop using Invega Sustenna 156mg/mL without first consulting your doctor. Tell your doctor if your condition persists or worsens.
Invega Sustenna Precautions
See also Warnings section. Before using paliperidone, tell your doctor or pharmacist if you are allergic to it; or to risperidone; or if you have any other allergies. Invega Sustenna 156mg/mL may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Invega Sustenna 156mg/mL, tell your doctor or pharmacist your medical history,kidney disease, low white blood cell count (leukopenia), seizures, Parkinson's disease, dementia, certain eye problems (cataracts, glaucoma), personal or family history of diabetes, high cholesterol/triglyceride levels, heart disease (such as previous heart attack), breathing trouble during sleep (sleep apnea). Paliperidone may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using paliperidone,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using paliperidone safely. Invega Sustenna 156mg/mL may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Invega Sustenna 156mg/mL may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness. Before having surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist if you are using or have ever used Invega Sustenna 156mg/mL, and about all the other products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Invega Sustenna 156mg/mL, especially drowsiness, dizziness, lightheadedness, and QT prolongation (see above). Drowsiness, dizziness, and lightheadedness can increase the risk of falling. During pregnancy, Invega Sustenna 156mg/mL should be used only when clearly needed. Babies born to mothers who have used Invega Sustenna 156mg/mL during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away. Since untreated mental/mood problems (such as schizophrenia, schizoaffective disorders) can be a serious condition, do not stop taking Invega Sustenna 156mg/mL unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using Invega Sustenna 156mg/mL during pregnancy. Invega Sustenna 156mg/mL passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops symptoms such as muscle stiffness or shakiness, unusual sleepiness, or difficulty feeding. Consult your doctor before breast-feeding.
Invega Sustenna Misdose
For the best possible benefit, it is important to receive each scheduled dose of Invega Sustenna 156mg/mL as directed. If you miss a dose of Invega Sustenna 156mg/mL, contact your doctor or pharmacist right away to establish a new dosing schedule.
Invega Sustenna Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.metoclopramide. Many drugs besides paliperidone may affect the heart rhythm (QT prolongation), including amiodarone, chlorpromazine, moxifloxacin, quinidine, sotalol, procainamide, thioridazine, among others. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Invega Sustenna Side Effects
What are Invega Sustenna side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Invega Sustenna may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Invega Sustenna as a result of an interaction with other medications.
Side Effects of Invega Sustenna
The side effects of Invega Sustenna may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Invega Sustenna. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Invega Sustenna may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Invega Sustenna, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Invega Sustenna.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Invega Sustenna, or any other medication, should contact their physician. General information about Invega Sustenna and the side effects associated with Invega Sustenna are described in the following:
Common Invega Sustenna Side Effects
- extrapyramidal disease
- acquired dystonia
- weight gain
- headache disorder
- injection site sequelae
Less Frequent Invega Sustenna Side Effects
- bundle branch block
- orthostatic hypotension
- menstrual disorder
- symptoms of anxiety
- blurred vision
- upper respiratory infection
- galactorrhea not associated with childbirth
- back pain
- general weakness
- sore throat
- acute abdominal pain
- increased appetite
Rare or Very Rare Invega Sustenna Side Effects
- diabetes mellitus
- thrombotic thrombocytopenic purpura
- oculogyric crisis
- sinus node dysfunction
- tardive dyskinesia
- neuroleptic malignant syndrome
- muscle rigidity
- increased alanine transaminase
- cerebrovascular accident
- cerebral ischemia
- increased aspartate transaminase
- prolonged QT interval
- seizure disorder
- sinus tachycardia
- tongue swelling
- aspiration pneumonia
- neutropenic disorder
- heart block
- transient cerebral ischemia
- esophageal dysmotility
- atrioventricular block
- accidental fall
- gastrointestinal obstruction
- acute confusion
- urinary tract infection
- muscle spasm
- pruritus of skin
- altered mental status
- urinary retention
- nasal congestion
- skin rash
- sleep walking disorder
- urinary incontinence
- complex sleep behavior
- sleep disorder
- retrograde ejaculation
- musculoskeletal pain
Invega Sustenna Storage
Not applicable. Invega Sustenna 156mg/mL is given in a clinic or doctor's office and will not be stored at home.
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