Mesalamine Side Effects

What are Mesalamine side effects?

Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Mesalamine may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Mesalamine as a result of an interaction with other medications.

Side Effects of Mesalamine

The side effects of Mesalamine may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Mesalamine. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Mesalamine may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Mesalamine, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Mesalamine.

By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Mesalamine, or any other medication, should contact their physician. General information about Mesalamine and the side effects associated with Mesalamine are described in the following:

Common Mesalamine Side Effects


  • colitis

Less Severe

  • acne vulgaris
  • dizziness
  • skin rash
  • headache disorder
  • Flatulence
  • fever

Less Frequent Mesalamine Side Effects


Less Severe

  • Flu-Like Symptoms
  • nausea
  • diarrhea
  • rectal pain
  • gastritis

Rare or Very Rare Mesalamine Side Effects


  • thrombocytopenic disorder
  • eosinophilia
  • pericarditis
  • alveolitis
  • rectal irritation
  • hepatitis
  • acute pancreatitis
  • nephrotoxicity
  • Drug Fever
  • Severe Headache Disorder
  • Bloody Diarrhea
  • Abdominal Pain with Cramps
  • abnormal hepatic function tests
  • hypersensitivity drug reaction
  • pyoderma gangrenosum
  • myocarditis
  • hepatic failure
  • lupus-like syndrome
  • obstructive hyperbilirubinemia
  • Jaundice
  • hepatic necrosis
  • agranulocytosis
  • aplastic anemia
  • Guillain-Barre syndrome
  • myelitis
  • hypersensitivity pneumonitis
  • erythema nodosum
  • gastrointestinal hemorrhage
  • intracranial hypertension
  • Nephrogenic Diabetes Insipidus

Less Severe

  • hemorrhoids
  • oligospermia
  • female infertility
  • pruritus ani
  • alopecia
  • back pain
  • limb pain
  • periorbital edema
  • constipation
  • Discolored Feces
  • Tenesmus
  • urticaria
  • peripheral neuropathy
  • Erythema
  • pruritus of skin
  • psoriasis