Vagifem Side Effects

What are Vagifem side effects?

Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Vagifem may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Vagifem as a result of an interaction with other medications.

Side Effects of Vagifem

The side effects of Vagifem may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Vagifem. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Vagifem may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Vagifem, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Vagifem.

By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Vagifem, or any other medication, should contact their physician. General information about Vagifem and the side effects associated with Vagifem are described in the following:

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Common Vagifem Side Effects


  • mastalgia
  • weight gain

Less Severe

  • mastalgia
  • weight gain
  • headache disorder
  • back pain
  • Abdominal Distension
  • infection
  • vulvovaginal candidiasis

Less Frequent Vagifem Side Effects


  • gynecomastia

Less Severe

  • libido changes
  • migraine
  • vaginal discharge
  • gynecomastia
  • cramps
  • acne vulgaris
  • pruritus of skin
  • General Weakness
  • vaginitis
  • Pelvic Pain
  • candidiasis

Rare or Very Rare Vagifem Side Effects


  • uterine leiomyoma
  • malignant neoplasm of the ovary
  • endometrial carcinoma
  • neoplasm of breast
  • dementia
  • acute myocardial infarction
  • pulmonary thromboembolism
  • cerebrovascular accident
  • deep venous thrombosis
  • hypertriglyceridemia
  • gallbladder obstruction
  • Endometrial Hyperplasia
  • thromboembolic disorder
  • retinal thrombosis
  • hypercalcemia
  • angioedema
  • precocious puberty
  • Anaphylaxis
  • hypersensitivity drug reaction

Less Severe

  • chloasma
  • nipple discharge
  • vaginal irritation
  • dysmenorrhea
  • metrorrhagia
  • urticaria
  • body fluid retention
  • hypertension
  • Abdominal Pain with Cramps
  • diarrhea
  • depression
  • insomnia
  • genital organ pruritus