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A New Compound Reduces Alzheimer Brain Damage by Half

By jeremyc | December 6, 2017

Several studies have declared APOE gene to be the key player in halting Alzheimer’s progression. However, not many studies have been able to successfully target this gene in animals. In a new study, the researchers successfully targeted APOE gene in mice using a molecule. This treatment reduced the brain damage caused by Alzheimer by 50 percent.

The risk of Alzheimer’s is known to rise significantly with APOE gene expression. As a matter of fact, E4 variant of APOE gene is found to be the biggest genetic risk factor for this neurodegenerative disease. More than 50 percent of people diagnosed with Alzheimer’s show APOE gene expression. People with both copies of APOE gene have been found to carry a 12-time greater risk of Alzheimer’s.

A previous study, done by the same researcher who conducted the present study, had identified the mechanism used by APOE gene to amplify Alzheimer’s brain damage in mice. In the latest study, the researchers have uncovered a molecule which inhibits APOE’s production, which in turn reduces Alzheimer’s brain damage.  The name of this molecule is antisense oligonucleotide.

In this study, the researchers injected antisense oligonucleotide in brains of some mice with genetic predisposition to develop Alzheimer’s. Some mice with the same genetic predisposition were given a placebo.

The researchers noted that the antisense molecule treated group had 50 percent fewer amyloid plaques, the hallmark of Alzheimer’s, in comparison to mice that were administered placebo. Further, in case of the antisense molecule treated group, each amyloid plaque caused 50 percent less neuronal damage.

Topics: | Alzheimer's/Dementia | No Comments »

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