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Giotrif Drug Information

By uds uds | November 23, 2018

Giotrif Drug Information - non-small cell lung cancer - Universal Drugstore Pharmacy News

Giotrif is prescribed to patients diagnosed with non-small cell lung cancer that has spread to other parts of the body.

Giotrif is a type of antiangiogenesis agent which belongs to a drug class known as kinase inhibitors. When used consistently, the medication helps to slow or stop the growth of cancerous cells.

Giotrif Helps Treat the Following Conditions:

Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is one of the most common types of lung cancer. Depending on the mutations within the tumor cell, NSCLC can have many different subsets. The three main types of NSCLC are adenocarcinoma, large cell carcinoma, and squamous cell carcinoma.

Unlike small cell lung cancer, NSCLC develops and spreads more slowly. One of the major causes of non-small cell lung cancer is smoking, however, there are other leading causes such as exposure to radon and a family history of lung cancer.

NSCLC treatment often includes surgery, radiation therapy, chemotherapy, and immunotherapy.


Marketed In the US as Gilotrif

In the US and some other parts of the world, you can buy Giotrif under the brand name Gilotrif.


Active Ingredients

Giotrif contains the active ingredient afatinib. Afatinib is a type of kinase inhibitor that works by binding to proteins found within cancer tumors, thereby slowing or stopping their growth.


What Is Giotrif?

Prior to starting treatment with Giotrif, the tumor(s) should be tested for a specific mutation that makes it more responsive to treatment. Giotrif should be used exactly as prescribed by your physician.

Most patients are directed to take the medicine once per day, at least one hour before (or two hours after) meals. Directions and dosage are dependent upon the patient’s medical condition and is determined by the patient’s prescribing physician.

Do not change your prescribed dose as this increases the risk of serious adverse effects.

If you miss a dose, take it within 12 hours of forgetting. If you remember to take it after 12 hours, do not double your dose to catch up.


Possible Drug Interactions

Certain drugs can have negative interactions with Giotrif. That’s why it is important to give your physician a full list of all prescription medications, over-the-counter drugs, and supplements you are taking.

Patients using rifamycin antibiotics like rifabutin – as well as seizure medications like phenobarbital and phenytoin – can affect the way Giotrif works.


Precautions and Adverse Effects

Giotrif is not recommended for use during pregnancy as it may harm the fetus. Female patients must use reliable contraception during Giotrif treatment, plus two weeks after treatment. Breastfeeding while using Giotrif is not recommended.

Pregnant women should not handle Giotrif or breathe the dust from the tablets.

Discuss the possibility of allergic reactions to Giotrif with your treating physician or pharmacist. Before you start treatment, discuss your medical history with your doctor. Notify them if you have/had kidney or liver disease. Be sure to mention any eye-related diseases such as keratitis and severe eye dryness.

In some patients, Giotrif increases sun sensitivity. Use sunscreen and limit your time in the sun. Avoid sunlamps and tanning booths. Contact your physician right away if you experience skin blisters, redness, and/or sunburn.

Some of the most common side effects of Giotrif include mouth sores, acne, and dry and itchy skin, as well as pain, redness, or swelling of the lips. Patients may also feel nauseous and lose their appetite. Notify your physician if any of these effects persist or worsen.

Giotrif may cause diarrhea. Patients are recommended to drink plenty of fluids and, if necessary, take antidiarrheal medicine.

More serious side effects include vision changes, eye discharge, light sensitivity, fever, and painful and frequent urination.

If you experience any lung or heart issues (e.g. trouble breathing, chest pain, swelling of the feet and/or ankles), seek immediate medical help.

In some rare cases, patients may develop serious liver disease. Seek immediate medical attention if you notice any of the following symptoms: vomiting, stomach pain, darkening urine, and yellowing of the skin and/or eyes.


Storage and Handling

It is recommended to store Giotrif in its original container, away from light and moisture. Keep at room temperature away from children and pets.

If your medication has expired or you do not need it anymore, make sure to dispose of it properly. To find out more about how to do so safely, contact a pharmacist or your local waste disposal company.


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Topics: | Cancer, Kinase Inhibitors, Lung Cancer | No Comments »

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