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Gabapentin Useful for Pain Intensity Reduction

By jeremyc | September 27, 2013

A recent study shows that gastro-retentive gabapentin is an effective, safe, and practical treatment option to reduce pain intensity and improve quality of life in patients diagnosed with postherpetic neuralgia (PHN). The study was done by Matthew Clark, MS, and colleagues from the A&A Pain Institute, St. Louis, Missouri.

The researchers for this study conducted a phase 4 multicenter, open-label study in order to test the real-world efficacy of gastro-retentive gabapentin on 197 patients diagnosed with active PHN. The patients were prescribed a dosage of 1800mg per day for a period of six weeks. Interference with daily life and pain intensity in patients were assessed in regular office visits.

By the end of the study, the researchers found that around 40.5 percent of the patients experienced a 50 percent or greater reduction in pain intensity by second week. By the end of the study, the percentage of patients with 50 percent or greater pain intensity reduction was 33.5 percent. The worst, least, average, and current pain intensity scores were significantly reduced by the second week and the end of the study.

The results of the study also showed that life interference scores like mood, walking ability, general activity, sleep, relationships, and so on changed for the better by the second week. By the end of the study, interference scores had reduced significantly. The gabapentin treatment dosage was also well-tolerated by most patients. The most common side effects were mild cases of somnolence and dizziness.

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