Duavee 0.45/20mg(Estrogens, Conjugated/Bazeoxifene Acetate)
Duavee Drug Information
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How Long Does It Take to Receive My Duavee Order?
You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.
Duavee 0.45/20mg is a combination product containing conjugated estrogens and bazedoxifene (an estrogen agonist/antagonist). Duavee 0.45/20mg is used by women with a uterus to help reduce symptoms of menopause (such as hot flashes, vaginal dryness) and to prevent bone loss (osteoporosis) after menopause. Conjugated estrogens are female hormones which help to decrease menopausal symptoms caused by the body making less estrogen. Bazedoxifene is not a hormone, but works by acting like estrogen (as a selective estrogen receptor modulator or SERM) in some parts of the body. The bazedoxifene in Duavee 0.45/20mg helps to preserve bone mass and reduces the risk of cancer of the uterus which can be caused by using estrogen. If you are using Duavee 0.45/20mg to treat symptoms only in and around the vagina, consider using products applied directly inside the vagina instead of medications that are taken by mouth, absorbed through the skin, or injected.
Women taking Duavee 0.45/20mg should not take additional estrogens, progestins, or additional estrogen agonist/antagonists (see also Drug Interactions section). Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus (endometrial cancer). The bazedoxifene in Duavee 0.45/20mg may help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks). The risk for serious side effects may depend on the dose of estrogen and the length of time Duavee 0.45/20mg is used. Therefore, Duavee 0.45/20mg should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of Duavee 0.45/20mg with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take Duavee 0.45/20mg. If you will be taking Duavee 0.45/20mg long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.
How to Use Duavee
Read the Patient Information Leaflet if available from your pharmacist before you start using Duavee 0.45/20mg and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Duavee 0.45/20mg by mouth with or without food as directed by your doctor, usually once daily. You may take it with food or right after a meal to prevent stomach upset. Swallow the tablet whole. Do not chew or crush. Doing so can release all of the drug at once, increasing the risk of side effects. Also do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The Dosage of Duavee 0.45/20mg is based on your medical condition and response to treatment. Take Duavee 0.45/20mg regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or take Duavee 0.45/20mg more often or for a longer time than directed. Tell your doctor if your condition does not improve or if it worsens.
Before taking Duavee 0.45/20mg, tell your doctor or pharmacist if you are allergic to conjugated estrogens or bazedoxifene; or if you have any other allergies. Duavee 0.45/20mg may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Duavee 0.45/20mg, tell your doctor or pharmacist your medical history,vaginal bleeding of unknown cause, diabetes, cancer (especially breast cancer, cancer of the uterus/ovaries), blood clots, blood clotting disorders (such as protein C or protein S deficiency), family medical history (especially of breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), gallbladder disease, heart disease (such as irregular heartbeat, previous heart attack), high blood pressure, high cholesterol/triglyceride levels, kidney disease, liver disease, lupus, mental/mood disorders (such as dementia, depression), migraine headaches, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), obesity, a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), asthma, seizures, stroke, a certain blood disorder (porphyria). Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35. Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop Duavee 0.45/20mg for a time or take special precautions. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Duavee 0.45/20mg may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur. Duavee 0.45/20mg must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away. Estrogens pass into breast milk and may reduce the quality and amount of breast milk produced. It is unknown if bazedoxifene passes into breast milk. Breastfeeding is not recommended while using Duavee 0.45/20mg. Consult your doctor before breastfeeding.
If you miss a dose of Duavee 0.45/20mg, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aromatase inhibitors (such as anastrozole, exemestane, letrozole), other estrogen agonist/antagonists (such as ospemifene, raloxifene), fulvestrant, tamoxifen, tranexamic acid. Duavee 0.45/20mg may interfere with certain laboratory tests (including metyrapone test, blood clotting tests, thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Duavee 0.45/20mg.
Duavee Side Effects
What are Duavee side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Duavee may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Duavee as a result of an interaction with other medications.
Side Effects of Duavee
The side effects of Duavee may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Duavee. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Duavee may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Duavee, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Duavee.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Duavee, or any other medication, should contact their physician. General information about Duavee and the side effects associated with Duavee are described in the following:
Common Duavee Side Effects
- upper abdominal pain
- muscle spasm
- neck pain
- pain in oropharynx
Less Frequent Duavee Side Effects
- back pain
- weight gain
- vulvovaginal candidiasis
- cramps in legs
- increased appetite
- vaginal discharge
- peripheral edema
- body fluid retention
- general weakness
- symptoms of anxiety
Rare or Very Rare Duavee Side Effects
- endometrial carcinoma
- cerebrovascular accident
- deep venous thrombosis
- pulmonary thromboembolism
- malignant neoplasm of the ovary
- gallbladder obstruction
- retinal vascular occlusion
- body fluid retention
- drug-induced hot flash
Store in the original package at room temperature away from light and moisture. Do not store in the bathroom. After opening the foil pouch, use the US product within 60 days and the Canadian product within 45 days. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Duavee 0.45/20mg when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
IMPORTANT DISCLAIMER: All medical content is supplied by a third-party company who is independent from this web site. As such, this web site cannot guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdictions depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.