Premarin Side Effects

What are Premarin side effects?

Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Premarin may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Premarin as a result of an interaction with other medications.

Side Effects of Premarin

The side effects of Premarin may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Premarin. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Premarin may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Premarin, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Premarin.

By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Premarin, or any other medication, should contact their physician. General information about Premarin and the side effects associated with Premarin are described in the following:

Common Premarin Side Effects


  • gynecomastia
  • mastalgia

Less Severe

  • headache disorder
  • abdominal distension
  • Acute Abdominal Pain

Less Frequent Premarin Side Effects


  • gastroenteritis
  • back pain
  • weight gain

Less Severe

  • vulvovaginal candidiasis
  • cramps in legs
  • migraine
  • candidiasis
  • vaginal discharge
  • dizziness
  • peripheral edema
  • insomnia
  • nausea
  • dysmenorrhea
  • diarrhea
  • body fluid retention
  • arthralgias
  • vaginitis
  • flatulence
  • General Weakness
  • constipation
  • myalgias
  • symptoms of anxiety
  • increased appetite

Rare or Very Rare Premarin Side Effects


  • uterine leiomyoma
  • malignant neoplasm of the ovary
  • endometrial carcinoma
  • neoplasm of breast
  • dementia
  • depression
  • lower seizure threshold
  • retinal thrombosis
  • acute myocardial infarction
  • pulmonary thromboembolism
  • cerebrovascular accident
  • thromboembolic disorder
  • thrombophlebitis
  • venous thrombosis
  • hypotension
  • Upper Respiratory Infection
  • Influenza
  • asthma exacerbation
  • ischemic colitis
  • hepatitis
  • gallbladder obstruction
  • acute pancreatitis
  • unspecified lump in breast
  • nipple discharge
  • endometrial hyperplasia
  • amenorrhea
  • menorrhagia
  • abnormal vaginal bleeding
  • Erythema Multiforme
  • erythema nodosum
  • urticaria
  • Involuntary Muscle Movement
  • skin rash
  • angioedema
  • Anaphylaxis
  • hypertension

Less Severe

  • hypertriglyceridemia
  • mood changes
  • libido changes
  • keratoconus
  • weight loss
  • pruritus of skin
  • alopecia
  • hirsutism
  • chloasma
  • vomiting
  • Nervousness
  • Pelvic Pain