Votrient Drug Information
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How Long Does It Take to Receive My Votrient Order?
You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.
Pazopanib is used to treat kidney cancer. It may also be used to treat certain other types of cancer (soft tissue sarcoma). Pazopanib belongs to a class of drugs known as tyrosine kinase inhibitors. It works by decreasing the blood supply to the cancer tumor to slow tumor growth. Votrient should not be used in children, especially younger than 2 years of age, because of the risk of serious side effects.
Pazopanib can rarely cause very serious (possibly fatal) liver disease. Your doctor will order blood tests to check your liver before you start and while you are taking pazopanib. During the first 2 months of treatment, liver tests will be done frequently, usually every 2 weeks. After 2 months, liver testing will be less frequent. Tell your doctor right away if you develop symptoms of liver disease such as dark urine, yellow eyes/skin, persistent nausea/vomiting, stomach/abdominal pain. Your doctor may need to change your dosage or discontinue the drug.
How to Use Votrient
Read the Medication Guide provided by your pharmacist before you start taking pazopanib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Votrient by mouth without food as directed by your doctor, usually once daily. It is very important to take Votrient on an empty stomach, at least 1 hour before or 2 hours after food. Swallow Votrient whole. Do not crush, chew, or break the tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Avoid eating grapefruit or drinking grapefruit juice while taking Votrient. Grapefruit can increase the amount of Votrient in your bloodstream. Consult your doctor or pharmacist for more details. Medications that reduce/block stomach acid (such as antacids, H2 blockers such as famotidine/ranitidine, proton pump inhibitors-PPIs such as omeprazole/lansoprazole) may reduce the absorption of pazopanib, making it work less well. Do not take H2 blockers or PPIs while using Votrient. If you are taking antacids, ask your pharmacist about how to best take them, such as taking antacids at least several hours apart from when you take pazopanib. Ask your doctor or pharmacist if you are taking any of these medications. Dosage of Votrient is based on your medical condition, laboratory tests, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor will order lab tests to find the best dose for you. Keep all medical and lab appointments. Do not increase your dose or take Votrient more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase. Use Votrient regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow your doctor's instructions carefully. Since Votrient can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle Votrient or breathe the dust from the tablets. Tell your doctor if your condition worsens.
Before taking pazopanib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Votrient may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Votrient, tell your doctor or pharmacist your medical history,liver disease, chest pain/heart attack, high blood pressure, stroke, bleeding/clotting problem, intestinal or stomach problems (such as ulcer, fistula, pancreatitis), underactive thyroid. Pazopanib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using pazopanib,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using pazopanib safely. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Pazopanib may slow wound healing or cause healing wounds to reopen. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Older adults may be more sensitive to the side effects of Votrient, especially liver disease or QT prolongation (see above). Tell your doctor if you are pregnant or plan to become pregnant. Your doctor will give you a pregnancy test before starting treatment. You should not become pregnant while using pazopanib. Pazopanib may harm an unborn baby. Women and men should ask about reliable forms of birth control to use during treatment with Votrient and for at least 2 weeks after stopping treatment. If you or your female partner becomes pregnant, talk to your doctor right away about the risks and benefits of Votrient. It is unknown if Votrient passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using Votrient and for 2 weeks after stopping treatment. Consult your doctor before breast-feeding.
If you miss a dose of Votrient, take it as soon as you remember. If it is less than 12 hours before your next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.irinotecan, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin). Aspirin can increase the risk of bleeding when used with Votrient. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details. Other medications can affect the removal of pazopanib from your body, which may affect how pazopanib works. Examples include azole antifungals (such as ketoconazole), nefazodone, rifamycins (such as rifabutin, rifampin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone), HIV protease inhibitors (such as ritonavir), among others. Many drugs besides pazopanib may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as clarithromycin, erythromycin), among others. Therefore, before using Votrient, report all medications you are currently using to your doctor or pharmacist.
Votrient Side Effects
What are Votrient side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Votrient may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Votrient as a result of an interaction with other medications.
Side Effects of Votrient
The side effects of Votrient may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Votrient. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Votrient may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Votrient, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Votrient.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Votrient, or any other medication, should contact their physician. General information about Votrient and the side effects associated with Votrient are described in the following:
Common Votrient Side Effects
- thrombocytopenic disorder
- neutropenic disorder
- thrombotic disorder
- general weakness
- skin rash
- weight loss
- headache disorder
- hair bleaching
- elevated serum lipase
- musculoskeletal pain
Less Frequent Votrient Side Effects
- arterial thrombosis
- acute myocardial infarction
- increased alanine transaminase
- increased aspartate transaminase
- acute abdominal pain
- palmar-plantar erythrodysesthesia
- chest pain
- voice change
- dry skin
- blurred vision
- nail disorders
- urinary tract infection
- skin hypopigmentation
Rare or Very Rare Votrient Side Effects
- hepatic failure
- gastrointestinal hemorrhage
- prolonged QT interval
- torsades de pointes
- gastrointestinal fistula
- gastrointestinal perforation
- hypertensive crisis
- retinal detachment
- thrombotic thrombocytopenic purpura
- hemolytic uremic syndrome
- chronic heart failure
- left ventricular failure
- venous thrombosis
- posterior reversible encephalopathy syndrome
- cerebrovascular accident
- impaired wound healing
- interstitial lung disease
- interstitial pneumonitis
- reactivation of hepatitis B
- pulmonary hemorrhage
- intracerebral hemorrhage
- new fistula formation involving an internal organ
- chemotherapy-induced hyperuricemia
- acute arterial thromboembolism
- arterial dissection
- arterial aneurysm
- facial edema
- muscle spasm
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Votrient when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.