What is the mechanism of action of Retatrutide?

Retatrutide is an investigational medication for obesity that is currently in development from Eli Lilly. It is considered a triple hormone agonist that works on 3 different receptors: glucagon-like peptide-1 receptor (GLP-1), glucagon receptor (GCG), and glucose-dependent insulinotropic polypeptide receptor (GIP). Because of this, it is sometimes called the “triple G” drug.
How does retatrutide help you lose weight?

By mimicking these hormones, retatrutide enhances insulin secretion, which helps your body use glucose for energy, and reduces glucagon secretion, which signals your liver to release less sugar. It slows down gastric emptying, which makes you feel full for longer. It also affects your brain’s reward pathways, reducing cravings to help you eat less.

Finally, retatrutide may increase energy expenditure, which means your body will burn more calories at rest and during activity.
This unique mechanism of action has showed promising results in clinical trials so far, with numbers than have exeeded other weight loss drugs like Wegovy (semaglutide) and Zepbound (tirzepatide).