Why is Prompro so expensive?

Prempro (conjugated estrogens/medroxyprogesterone acetate) is an expensive brand‑name medication with no generic version available at this time. It is FDA‑approved to treat menopausal symptoms and help prevent osteoporosis.

The average retail cost for a 28‑day supply (one pack) of Prempro 0.3 mg/1.5 mg tablets is over $300. Your out‑of‑pocket cost will depend on your insurance plan. Under Medicare Part D, copays range from $4 to $270 after you’ve met your deductible.

If you cannot afford Prempro, there are programs and resources that may help lower the cost:

  • Pfizer Pathways: a manufacturer assistance program that may cover part or all of your medication cost, based on eligibility.
  • Universal Drug Store (UDS): an online pharmacy offering Prempro at discounted prices without a coupon or card, often over 60% below average retail.
  • Medicaid: low‑income individuals may qualify for Medicaid, which may cover Prempro.
  • Prescription discount cards: these cards can be used at local pharmacies to reduce out‑of‑pocket costs.
  • Price comparison: shopping around at multiple pharmacies (local, mail‑order, online) can save hundreds of dollars per prescription.
  • Alternative therapies: other hormone replacement options (oral, transdermal, vaginal) or non‑hormonal treatments may be lower cost.

Prempro FAQs

What Is Prempro Prescribed For?

Prempro is FDA‑approved to:

  • Treat vasomotor symptoms (hot flashes, night sweats, vaginal dryness) caused by menopause
  • Prevent osteoporosis (bone loss) after menopause

How Does Prempro Work?

Prempro combines:

  • Conjugated estrogens – replace the estrogen lost during menopause, relieving symptoms and strengthening bones
  • Medroxyprogesterone – a progestin that protects the uterus from estrogen‑induced cancer

What Are the Side Effects of Prempro?

Common side effects include:

  • Breast pain
  • Stomach pain
  • Headache
  • Gas
  • Nausea
  • Mood swings or depression
  • Vaginal discharge
  • Back pain
  • Itching
  • Irregular periods
  • Weakness

Other possible side effects:

  • Bloating
  • Dizziness
  • Weight gain
  • Migraines
  • Menstrual cramps
  • Urinary incontinence
  • Vision changes

Rare but serious side effects may include:

  • Heart attack or stroke
  • Increased risk of dementia
  • Blood clots (pulmonary embolism, deep vein thrombosis)
  • Increased risk of breast or ovarian cancer
  • Gallbladder disease
  • Liver problems
  • High blood sugar or blood pressure
  • Uterine fibroids
  • Severe allergic reactions (hives, facial swelling, trouble breathing)

Consult your healthcare professional for medical advice. Report adverse reactions to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Who Should Avoid Taking Prempro?

Prempro carries an FDA Boxed Warning. Do not use if you have:

  • An allergy to any ingredient in Prempro
  • Undiagnosed vaginal bleeding
  • A history of breast or endometrial cancer
  • A history of heart attack, stroke, or blood clots
  • Liver disease or bleeding disorders
  • Known or suspected pregnancy

Combined estrogen–progestin therapy should not be used to prevent cardiovascular disease or dementia, especially in women aged 65 or older.

What Should Your Doctor Know Before You Start Prempro?

Inform your provider if you have:

  • Hypothyroidism
  • History of angioedema
  • Migraines or seizures
  • Endometriosis
  • Asthma or diabetes
  • Blood disorders or high blood calcium
  • Kidney, liver, or heart problems
  • Use of contact lenses
  • Breastfeeding or plans to breastfeed
  • Lupus

What Drugs Interact with Prempro?

Prempro may interact with:

  • St. John’s Wort
  • Phenobarbital
  • Carbamazepine
  • Rifampin
  • Clarithromycin or erythromycin
  • Itraconazole or ketoconazole
  • Ritonavir
  • Grapefruit juice

How Much Does Prempro Cost?

The average retail price for one 28‑day pack of Prempro 0.3 mg/1.5 mg tablets is over $300. Your copay depends on your insurance plan and deductible.

How Can You Save Money on Prempro?

  • Universal Drug Store (UDS): one pack for around $108, over 60% off retail.
  • Pfizer Pathways: manufacturer assistance program for eligible patients.
  • Medicaid: coverage for low‑income individuals.
  • Discount cards: available at local pharmacies.
  • Price comparison: shop multiple pharmacies for best price.
  • Alternative therapies: other HRT options or non‑hormonal treatments.

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