Buy Migranal Online

(Dihydroergotamine Mesylate)

Migranal contains dihydroergotamine, an ergot alkaloid. It helps treat migraine headaches by narrowing certain blood vessels involved in a migraine attack.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Migranal. However, the following is a synopsis of the general guidelines for the use of Migranal:

• It is for use in the nose only and must not be injected.
• Only assemble the sprayer once you are ready to use it. To assemble, remove the blue cover, metal seal, and rubber stopper. Then remove the plastic cover from the base of the pump unit, and insert the spray pump into the vial, turning clockwise until secure.
• Before the first dose, the pump must be primed by squeezing it 4 times away from your face.
• Spray once into each nostril without tilting your head back or sniffing (do not sniff during or immediately after use). Wait 15 minutes, then repeat.
• Once the applicator has been prepared, it should be discarded with any remaining medicine after 8 hours.
• The safety of more than 3 mg in a 24-hour period or more than 4 mg in a 7-day period has not been established. Migranal should not be used for chronic daily administration.

Some mild or common side effects of Migranal seen in clinical trials as compared to placebo include:

• Runny nose.
• Nausea or an altered sense of taste.
• Dryness or irritation in the nose may also occur with a nasal spray.

Some individuals may experience serious side effects while using Migranal. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of heart problems, including chest pain, shortness of breath, clammy skin, muscle pain or weakness in the arms or legs, numbness or tingling in your fingers and toes, or a change in heart rate.
• Signs of an allergic reaction, such as hives, tightness in your throat, or chest pain.

These are not all of the possible side effects of Migranal. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Migranal, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Risk factors for heart disease, such as hypertension, high cholesterol, smoking, obesity, postmenopausal females (or males over 40 years old), and a strong family history of coronary artery disease (CAD).
• Compromised circulation (Raynaud’s syndrome).

• Concurrent use of strong CYP3A4 inhibitors, such as protease inhibitors and macrolide antibiotics, as well as ketoconazole and itraconazole.
• Known heart disease, including peripheral artery disease, ischemic heart disease, angina, a history of myocardial infarction, silent ischemia, coronary artery vasospasm, or uncontrolled hypertension.
• Use within 24 hours of a 5-HT1 agonist or triptan, ergotamine-containing or ergot-type medications, or methysergide.
• Hemiplegic or basilar migraine.
• Known sepsis or following heart surgery.
• Severe kidney or liver disease.
• Pregnancy or breastfeeding.
• Known hypersensitivity to ergot alkaloids.

Most patients respond within 2-4 hours after taking Migranal, but response time can differ between people.

When Migranal is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Strong CYP3A4 inhibitors such as protease inhibitors, erythromycin, clarithromycin, ketoconazole, and itraconazole can raise dihydroergotamine levels and increase the risk of vasospasm and serious ischemia. These medications should not be used concurrently with Migranal.
• Less potent CYP3A4 inhibitors such as grapefruit juice or fluoxetine can be used together with Migranal with caution, but the latter may require a dose reduction.
• Sumatriptan and other triptans may have additive effects on blood vessels, so they should not be used within the same 24-hour period.
• Peripheral or central vasoconstrictors may cause additive or synergistic elevation of blood pressure.

Migranal nasal spray is supplied as a 4 mg/mL solution in a 3.5 mL amber glass vial. Each package contains 8 units, and each unit includes one vial and one sprayer.

It should be stored at room temperature, out of the reach of children and pets.

It is manufactured by Bausch Health.

Yes, it is available from many manufacturers of generic drugs.

This medication should only be used as needed for migraines.

No. Migranal is contraindicated in pregnancy, as it may cause fetal harm.

No, it is likely excreted in human milk, and ergot drugs may cause serious adverse effects in nursing infants.