Migranaland/or alternativesChemical Ingredient: Dihydroergotamine Mesylate
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
0.5mg/Inh Metered-Dose Nasal Spray
No generic is available for Migranal 0.5mg/Inh.
- Manufactured by Sterimax Inc.
- Product of Canada • Shipped from Canada
- Prescription Required
No generic is available for Migranal 0.5mg/Inh.
Please Note: Migranal Nasal Spray 4mg/mL delivers 0.5mg/Inhalation.
Migranal Drug Information
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Migranal Drug Information
Migranal is used to treat migraine headache attacks. It helps relieve headache pain and other symptoms such as sensitivity to light or sound. Prompt treatment allows you to get back to your normal routine sooner and may decrease your need for other pain medications. Migranal is not used to prevent migraines from occurring. Dihydroergotamine belongs to a class of drugs known as ergot alkaloids. It may work by narrowing the blood vessels in the brain. It may also block other pain pathways in the brain.
Migranal has rarely caused a very serious lack of blood flow to the hands and feet (peripheral ischemia) or to the brain, which could cause a stroke. The risk is increased when Migranal is taken with other drugs that can affect the removal of dihydroergotamine from your body. Examples include azole antifungals (such as ketoconazole, itraconazole), boceprevir, cobicistat, mifepristone, telaprevir, certain antidepressants (such as nefazodone), macrolide antibiotics (such as clarithromycin, erythromycin, troleandomycin), HIV NNRTIs (such as delavirdine), HIV protease inhibitors (such as ritonavir, nelfinavir, indinavir), SSRIs (such as fluoxetine, paroxetine, fluvoxamine), among others.
How to Use Migranal
Read the Patient Information Leaflet provided by your pharmacist before you start using dihydroergotamine and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist. Migranal comes in individual nasal spray vials. Each vial contains enough medication to treat a single migraine attack. Do not use more than 4 sprays for a single attack. Before using each nasal spray vial, prime the pump by spraying 4 times into the air, away from the face. At the first sign of a migraine, spray Migranal into the nostrils. Do not inject Migranal. Use 1 spray into each nostril. Do not tilt your head back, sniff through your nose, or blow your nose while spraying or immediately after. Use another spray into each nostril 15 minutes after the first sprays, or use as directed by your doctor. After using the medication, you should lie down and relax in a quiet, darkened room. The maximum number of sprays you can use for a single attack is 4 sprays (two in each nostril). You should feel some relief within 30 minutes of using Migranal. The Dosage of Migranal is based on your medical condition and response to treatment. Ask your doctor how often you can use Migranal to treat your migraine headaches. Do not increase your dose or use Migranal more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Migranal works best if Migranal is used as the first signs of the headache occur. If you wait until the headache has worsened, the medication may not work as well. Use only as needed to treat migraine attacks when they occur. It is not meant for long-term daily use. If you have never used Migranal before and you have risk factors for heart disease (see Precautions), you may need to be monitored for rare but serious side effects (such as chest pain) when you take the first dose. Your doctor may ask you to take the first dose in the office. If you also take "triptan" or other ergot medications (such as sumatriptan, methysergide), wait 24 hours before and after taking dihydroergotamine. Consult your doctor or pharmacist for more details and for advice on how to time your doses of these medications. If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use Migranal more often, or if the medication is not working as well, or if your headaches get worse.
Before using dihydroergotamine, tell your doctor or pharmacist if you are allergic to it; or to other ergot alkaloids (such as ergotamine, methysergide, bromocriptine); or if you have any other allergies. Migranal may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Migranal, tell your doctor or pharmacist your medical history,heart disease (such as chest pain/angina, heart attack), stroke, high blood pressure, blood circulation disease (such as peripheral arterial disease, Raynaud's syndrome), a certain severe blood infection (sepsis), bowel disease (such as ischemic bowel syndrome), kidney disease, liver disease, headaches with unusual symptoms or certain types of headache (hemiplegic/basilar), recent blood vessel surgery, nasal problems (such as chronic congestion, nasal allergies).high blood pressure, high blood cholesterol, obesity, diabetes, smoking/tobacco use, family history of heart disease. If you are at high risk for heart disease, your doctor may want to check your heart before prescribing dihydroergotamine and give your first dose in the office. Migranal may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Using tobacco/nicotine products while using Migranal can increase the risk of serious side effects such as heart problems (such as chest pain, fast/slow/irregular heartbeat) and decreased blood supply to the brain/hands/feet. Do not use tobacco while taking Migranal. If you smoke, talk to your doctor about how to stop smoking. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Migranal must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away. Migranal passes into breast milk and may harm a nursing infant. Do not breast-feed while using Migranal.
Take Migranal only as needed when a migraine occurs, as directed by your doctor. Migranal is not taken on a regular schedule.
See also Warning and How to Use sections. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.bronchodilators/decongestants/stimulants (such as epinephrine, pseudoephedrine, methylphenidate, amphetamine). Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or other migraine medications).
Migranal Side Effects
What are Migranal side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Migranal may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Migranal as a result of an interaction with other medications.
Side Effects of Migranal
The side effects of Migranal may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Migranal. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Migranal may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Migranal, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Migranal.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Migranal, or any other medication, should contact their physician. General information about Migranal and the side effects associated with Migranal are described in the following:
Common Migranal Side Effects
- nasal passage irritation
- drug-induced hot flash
- muscle rigidity
- general weakness
Less Frequent Migranal Side Effects
Rare or Very Rare Migranal Side Effects
- acute myocardial infarction
- coronary artery spasm
- myocardial ischemia
- valvular sclerosis
- cardiac arrhythmia
- peripheral ischemia
- upper respiratory infection
- pleural fibrosis
- pulmonary fibrosis
- retroperitoneal fibrosis
- acute confusion
- symptoms of anxiety
- blurred vision
- eye tearing
- ocular pain
- orthostatic hypotension
- pruritus of skin
- muscle weakness
- skin rash
- clammy skin
- abdominal pain with cramps
Store at room temperature away from heat, light, and moisture. Do not freeze or refrigerate. Do not store in the bathroom. Discard opened nasal spray vials 8 hours after opening. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Migranal when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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