Abilify withdrawal symptoms: What to expect when stopping antipsychotics

Abilify (aripiprazole) is used to treat various mental health conditions by restoring neurotransmitter balance. It is crucial not to abruptly stop taking this medication due to the risk of withdrawal symptoms, often referred to as discontinuation syndrome.

Understanding Abilify’s Impact on the Brain

Abilify works primarily by influencing dopamine and serotonin receptors, which can significantly affect mood, thinking, and behavior.

What Happens When You Stop Taking Abilify?

Stopping Abilify suddenly can lead to withdrawal symptoms and potentially rebound psychosis. Symptoms may include anxiety, insomnia, nausea, dizziness, cognitive impairment, headaches, flu-like symptoms, tardive dyskinesia, depression, and fatigue.

Duration of Withdrawal Symptoms

Withdrawal symptoms typically begin within a week of stopping and can last for up to a month or more, depending on various factors including dosage and duration of treatment.

Common Side Effects of Abilify

While taking Abilify, side effects may include nausea, vomiting, constipation, headaches, dizziness, and more severe conditions like neuroleptic malignant syndrome or impulse control problems.

Discontinuing Abilify Safely

The safest way to stop taking Abilify is by gradually tapering the dose under medical supervision to minimize withdrawal symptoms.

Lifestyle Tips During Tapering

Maintaining a healthy lifestyle, including adequate sleep, regular exercise, and a balanced diet, can help manage withdrawal symptoms. Open communication with healthcare providers and support networks is also crucial.

Sources

  • Brandt L, et al. (2020). Antipsychotic withdrawal symptoms: A systematic review and meta-analysis. Frontiers in Psychiatry.
  • Sansone, R. A., & Sawyer, R. J. (2013). Aripiprazole withdrawal: a case report. Innovations in clinical neuroscience.
  • Read J. (2022). The experiences of 585 people when they tried to withdraw from antipsychotic drugs. Addictive behaviors reports.
  • Abilify (aripiprazole) prescribing information. Otsuka America Pharmaceutical, Inc.