Claritin vs. Zyrtec: Which is best for me?

Both Claritin (loratadine) and Zyrtec (cetirizine hydrochloride) are popular choices for treating allergy symptoms, but they have key differences in their effects and side effects. This article will help you understand these differences and choose the right one for your needs.
How Claritin and Zyrtec Work
Both are second-generation antihistamines that block the histamine 1 receptor to reduce allergic reactions.
Side Effects of Claritin and Zyrtec
While both are generally well-tolerated, Zyrtec may cause drowsiness in some people more so than Claritin.
Effectiveness for Allergy Relief
Both are effective, but Zyrtec might work quicker and be more effective for some users compared to Claritin.
Drug Interactions and Warnings
Interactions with CNS depressants are significant for both medications. Claritin’s effectiveness can be affected by drugs that influence liver enzymes.
Special Considerations
Older adults, young children, and those with certain health conditions should consult a healthcare provider before using these medications.
Other OTC Allergy Treatments
Alternatives include steroid nasal sprays like Nasacort and Flonase, and decongestants like Sudafed and Afrin, which should be used with caution.
Switching Between Zyrtec and Claritin
Switching is possible but not usually necessary; do not mix them directly and allow time between switching.
Sources
- StatPearls Publishing
- Allergy Asthma Clinical Immunology
- J Investig Allergol Clin Immunol