How Do You Take Zyprexa Zydis Dissolving Tablets?

What Are Zyprexa Zydis Dissolving Tablets?

Zyprexa Zydis (olanzapine) is a medication used to treat schizophrenia, bipolar disorder, and other mental health conditions. Unlike regular tablets that you swallow whole with water, Zyprexa Zydis comes in a special dissolving form called orally disintegrating tablets. These tablets melt quickly in your mouth without needing any liquid.

The dissolving tablets are designed for people who have trouble swallowing pills or prefer not to use water when taking their medication. They work exactly like regular Zyprexa tablets but offer a more convenient way to take your prescribed dose.

Step-by-Step Instructions for Taking Zyprexa Zydis

Before You Handle the Tablet

Make sure your hands are completely dry before touching the blister pack. Even small amounts of moisture can cause the tablet to start dissolving before you put it in your mouth.

Do not open the blister pack until you are ready to take your dose. The special packaging protects the tablet from moisture and keeps it stable until you need it.

Why Pay Full Price?

Search our full medication catalogue and save up to 80% - no insurance needed.

See Prices Now

Opening the Package

Peel back the foil backing on the blister pack carefully. Never push the tablet through the foil from the back, as this can damage or break the tablet. The correct way is to peel the foil away from the plastic bubble that contains the tablet.

If the tablet breaks or crumbles when you remove it, do not use that tablet. Take a new one from another blister.

Taking the Tablet

Place the entire Zyprexa Zydis tablet in your mouth immediately after opening the package. The tablet will start to dissolve quickly in your saliva. You do not need water to take this medication.

Allow the tablet to dissolve completely in your mouth, then swallow. If you prefer, you can take a sip of water after the tablet melts.

Do not cut, crush, or chew Zyprexa Zydis tablets. These actions can change how the medication works and may affect how well it helps your condition.

Alternative Method: Mixing with Liquid

Some patients prefer to dissolve Zyprexa Zydis in a drink rather than directly in their mouth. This method is also approved and safe.

You can place the tablet in a full glass of water, orange juice, apple juice, milk, or coffee. Stir the liquid and drink it right away. However, do not use cola drinks, as they may interfere with how the tablet dissolves.

This liquid method can be helpful for caregivers giving the medication to children or adults who need assistance taking their medicine.

When and How Often Do You Take Zyprexa Zydis?

Daily Timing

Zyprexa Zydis is typically taken once daily. Take your dose at the same time every day to maintain steady levels of the medication in your body. This consistent timing helps the medication work most effectively.

You can take Zyprexa Zydis with or without food. Meals do not affect how well the medication is absorbed, so choose a time that works best with your daily routine.

Missed Doses

If you forget to take your dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Never take two doses at once to make up for a missed dose.

How Do You Store Zyprexa Zydis Tablets?

Store your Zyprexa Zydis tablets in their original sealed packaging until you are ready to use them. The special blister packs protect the tablets from moisture, which could cause them to dissolve prematurely.

Keep the medication at room temperature, away from moisture and heat. Do not store Zyprexa Zydis in bathrooms or kitchens where humidity levels can be high.

Use each tablet immediately once you open its individual blister pack. Do not save opened tablets for later use, as exposure to air and moisture will cause them to break down.

Important Safety Considerations

Following Your Prescription

Only take the amount of Zyprexa Zydis prescribed by your doctor. Do not increase or decrease your dose without medical supervision. The dissolving tablets contain the same active ingredient as regular Zyprexa tablets, so they have the same potency and effects.

If you have questions about your dosing schedule or experience side effects, contact your healthcare provider rather than adjusting the medication on your own.

Drug Interactions

Inform all your healthcare providers that you are taking Zyprexa Zydis, including dentists and specialists. The medication can interact with other drugs, alcohol, and some medical procedures.

Maintain a current list of all medications, supplements, and over-the-counter products you use. Share this list with your doctor and pharmacist to check for potential interactions.

FAQs

Can I Break or Split the Tablets?

No, you should never break, split, crush, or chew Zyprexa Zydis tablets. These tablets are designed to dissolve intact in your mouth. Altering them can change how much medication you receive and may affect their effectiveness.

What If I Accidentally Get the Tablet Wet?

If moisture gets on the tablet before you put it in your mouth, it may start to dissolve or become difficult to handle. If this happens, try to take the tablet immediately if it is still mostly intact. If the tablet has completely dissolved or crumbled, discard it and take a new one.

Is It Normal to Taste the Medication?

Yes, you may notice a taste as the Zyprexa Zydis tablet dissolves in your mouth. This is normal. The dissolving process happens quickly, so any taste should not last long.

Can I Eat or Drink Right After Taking It?

You can eat or drink normally after taking Zyprexa Zydis. Since the medication can be taken with or without food, there are no specific restrictions about consuming other items after your dose.

When to Contact Your Healthcare Provider

Reach out to your doctor if you have persistent trouble taking Zyprexa Zydis tablets or if you experience any concerning symptoms. Your healthcare team can provide additional guidance on proper administration techniques or discuss alternative medication forms if needed.

If you have questions about timing, storage, or interactions with other medications, your pharmacist can also provide helpful information specific to your situation.

Remember that Zyprexa Zydis is an important part of your treatment plan. Taking it correctly and consistently helps ensure you receive the full benefit of the medication while minimizing potential complications.

References

• Zyprexa- olanzapine tablet; Zyprexa Zydis- olanzapine tablet, orally disintegrating; Zyprexa Intramuscular- olanzapine injection, powder, for solution [package insert]. Eli Lilly and Company. Last updated 2/2021. Accessed July 14, 2026.
• Olanzapine (Oral Route). Mayo Clinic. Accessed July 14, 2026.
• Olanzapine Disintegrating Tablets. Cleveland Clinic. Accessed July 14, 2026.
• Zyprexa & Zyprexa Zydis Consumer Medicine Information. Medsafe. Last updated 11/2025. Accessed July 14, 2026.