How to Use Stiolto Respimat: Complete Step-by-Step Guide for COPD Treatment
Chronic obstructive pulmonary disease (COPD) is a lung condition that makes breathing difficult. It includes conditions like chronic bronchitis and emphysema.
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,Stiolto Respimat (tiotropium bromide and olodaterol) is a prescription medication designed to help people with COPD breathe easier. This soft mist inhaler combines two medicines that work together to open your airways and keep them open longer.
Learning how to use this device correctly is essential for getting the full benefit of your treatment.
In This Article
- What Is Stiolto Respimat and How Does It Work?
- Preparing Your Stiolto Respimat for First Use
- Step-by-Step Instructions for Using Stiolto Respimat
- Important Safety Guidelines and Precautions
- Proper Inhaler Care and Maintenance
- Common Mistakes to Avoid
- What to Expect When Starting Treatment
- Managing Side Effects
- Cost Considerations and Affordability Options
- When to Contact Your Healthcare Provider
- References
What Is Stiolto Respimat and How Does It Work?
Stiolto Respimat contains two active ingredients, tiotropium bromide and olodaterol. They are 2 types of bronchodilators that work differently to improve your breathing. Tiotropium bromide is a long-acting muscarinic antagonist (LAMA), a type of anticholinergic medication. It helps keep your airways open for 24 hours by blocking a chemical in your lungs called acetylcholine. Olodaterol is a long-acting beta agonist (LABA) that works quickly by relaxing the muscles in your airways. Together, these medications provide around-the-clock relief from COPD symptoms.
The Respimat device creates a fine, slow-moving mist that makes it easier to inhale the medication deep into your lungs. Unlike other inhalers that require you to breathe in very hard and fast, the Respimat works better with slow, steady breathing. This makes it a good choice for people who have trouble using traditional inhalers.
The standard dose is two inhalations once daily, and you should not exceed more than two inhalations in a 24-hour period.
Preparing Your Stiolto Respimat for First Use
When you get a new Stiolto Respimat inhaler, you need to set it up before using it for the first time. This process is called priming, and it ensures the device delivers the right amount of medication.
Initial Setup Steps:
- Take off the clear plastic cap from the bottom of the inhaler.
- Push the medication cartridge firmly into the inhaler until it clicks.
- Put the clear cap back on the bottom.
- Turn the clear base in the direction of the arrows until it clicks.
- Press the dose release button while pointing away from your face. You should see a mist come out.
- Repeat this process three more times until you get a good, visible mist each time.
Step-by-Step Instructions for Using Stiolto Respimat
Once your inhaler is primed and ready, follow these steps each time you take your daily dose:
Before Taking Your Dose
Check the dose indicator window to make sure you have medication left in your inhaler. With the cap closed, turn the clear base in the direction of the arrows until it clicks. This loads one dose of medication.
Taking Your First Inhalation
- Remove the cap: Take off the cap and set it aside where you will not lose it.
- Position yourself: Stand or sit up straight to help the medication reach deep into your lungs.
- Breathe out: Exhale normally, but not into the inhaler mouthpiece.
- Create a seal: Close your lips around the mouthpiece without covering the air vents on the sides.
- Start breathing in slowly: Begin taking a slow, deep breath through your mouth.
- Press and continue breathing: While breathing in, press the dose release button and keep breathing in slowly and deeply.
- Hold your breath: Remove the inhaler from your mouth and hold your breath for 10 seconds or as long as comfortable.
- Breathe out slowly: Exhale away from the inhaler.
Taking Your Second Inhalation
For your complete daily dose, you need to take two puffs. Repeat the preparation step by turning the clear base until it clicks again. Then follow the same breathing technique for your second inhalation. After both puffs, replace the cap on your inhaler.
Important Safety Guidelines and Precautions
Stiolto Respimat is designed for daily maintenance treatment of COPD. This means you should use it every day, even when you feel good and are not having breathing problems. It is not a rescue inhaler for sudden breathing emergencies.
Key Safety Points:
- Daily use only: Take two puffs once per day, at the same time each day.
- Not for emergencies: Do not use for sudden shortness of breath or asthma attacks.
- Maximum dose: Never take more than two inhalations in 24 hours.
- Mouth care: Rinse your mouth with water after each use to prevent thrush.
If you miss a dose, take it as soon as you remember, but do not take two doses at the same time to make up for a missed dose. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule.
Proper Inhaler Care and Maintenance
Taking care of your Stiolto Respimat inhaler helps ensure it works properly and lasts as long as it should. Each cartridge contains 60 doses, which equals 30 days of treatment when used correctly.
Daily Maintenance
After each use, wipe the outside of the mouthpiece with a clean, dry cloth. Never wash the inhaler or put it in water. Keep the cap on when you are not using the device to protect it from dust and damage.
Storage Requirements
Store your inhaler at room temperature, away from heat and direct sunlight. Do not freeze the device or leave it in hot places like your car. The medication can be damaged by extreme temperatures, which may make it less effective.
When to Replace Your Inhaler
The dose indicator shows you how much medication is left. When it shows a red zone, you have about seven days of medication remaining. Get a new prescription before your current inhaler runs out completely. Do not try to refill or reuse the cartridge.
Common Mistakes to Avoid
Many people make mistakes when learning how to use their Stiolto Respimat inhaler. Being aware of these common errors can help you get better results from your treatment.
Breathing Technique Mistakes:
- Breathing too fast: The mist needs time to reach deep into your lungs.
- Not holding your breath: Holding your breath helps the medication settle in your airways.
- Covering air vents: Keep your fingers away from the small holes on the sides of the device.
- Breathing out into the inhaler: This can block the device and waste medication.
Preparation Mistakes:
- Forgetting to prime: New inhalers and those not used for more than three days need priming.
- Not turning the base: Each dose requires turning the clear base until it clicks.
- Using without clicking sound: The click confirms that a dose is loaded and ready.
What to Expect When Starting Treatment
When you first start using Stiolto Respimat, you may not notice immediate improvement in your breathing. This medication works gradually to improve your lung function over time. Some people notice better breathing within a few hours, while others may need several days or weeks to feel the full benefits.
Continue using your inhaler every day as prescribed, even if you do not feel immediate relief. Stopping and starting the medication can prevent you from getting the full benefits of treatment. If you have concerns about how the medication is working, talk to your healthcare provider before making any changes.
Managing Side Effects
Like all medications, Stiolto Respimat can cause side effects, though not everyone experiences them.
Common Side Effects:
- Cough
- Runny or stuffy nose
- Sore throat
- Headache
- Back pain
Serious but Rare Side Effects:
- Eye problems like glaucoma or blurred vision
- Difficulty urinating
- Fast or irregular heartbeat
- High blood pressure
- Sudden narrowing of your airways (bronchospasm) and trouble breathing
- Severe allergic reactions
Most side effects are mild and go away as your body gets used to the medication. Rinsing your mouth with water after each use can help prevent throat irritation and oral thrush. Contact your healthcare provider if you experience any severe or persistent side effects.
Cost Considerations and Affordability Options
Stiolto Respimat is a brand-name medication that can be expensive, especially for people without comprehensive insurance coverage. The cost can vary significantly depending on your insurance plan, location, and pharmacy.
For patients seeking more affordable access to their COPD medications, exploring cash-pay options through Universal Drugstore can provide significant savings compared to traditional retail pharmacy prices. Many patients find that paying cash through reliable online pharmacies offers more predictable pricing and can be more affordable than high insurance copays or deductibles.
Before making any decisions about where to fill your prescription, compare prices from multiple sources and consider factors like convenience, reliability, and customer service in addition to cost.
When to Contact Your Healthcare Provider
Regular communication with your healthcare provider is important when using Stiolto Respimat for COPD management. Schedule follow-up appointments to discuss how well the medication is working and whether any adjustments are needed.
Contact your provider if you experience:
- Worsening shortness of breath
- More frequent COPD flare-ups
- New or unusual symptoms
- Difficulty using the inhaler properly
- Questions about your treatment plan
Your healthcare provider may also want to check your lung function periodically to see how well the medication is working. These tests help determine whether your current treatment plan is right for you or if changes might be beneficial.
Learning how to use Stiolto Respimat correctly takes practice, but proper technique ensures you get the maximum benefit from your COPD treatment. Take your time with each step, and do not hesitate to ask your healthcare provider or pharmacist to review the technique with you if you have questions.
References
- Boehringer Ingelheim Pharmaceuticals, Inc. How to use Stiolto Respimat. Accessed May 30, 2026.
- Boehringer Ingelheim Pharmaceuticals, Inc. (2021). Welcome to your Respimat quick-start guide. Accessed May 30, 2026.
- Stiolto Respimat- tiotropium bromide and olodaterol spray, metered [package insert]. Boehringer Ingelheim Pharmaceuticals Inc. DailyMed. Last updated 6/2025. Accessed May 30, 2026.
- How to Use a Respimat Inhaler. Asthma + Lung UK. 2021. Accessed May 30, 2026.
- How to Use a Respimat Soft Mist Inhaler. American Lung Association. 2020. Accessed May 30, 2026.