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Buy Diane-35 Online
(Cyproterone Acetate/Ethinyl Estradiol)

What is Diane-35?

What is Diane-35?

Brand-name Diane-35 (cyproterone acetate and ethinyl estradiol) is a prescription hormonal therapy used in health care. It is indicated for the treatment of severe acne, seborrhea, and conditions related to hyperandrogenism, such as hirsutism in females of reproductive age, when other treatments have not worked. Some common side effects are nausea, breast pain, and breakthrough bleeding.

Order Diane-35 online today and save!

Purchase Diane-35 from Universal Drugstore today and save!

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  • All Strength's
  • 2/0.035mg

Diane-35 brand

Diane-35 21 Day 
2/0.035mg

Prescription Required
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Prescription Required
Product of Canada

Product of Canada

Dianette 
2/0.035mg

Prescription Required
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Prescription Required
Product of United Kingdom

Product of United Kingdom

Cyproterone Acetate/Ethinyl Estradiol (generic Diane-35)

What are generics?

Cyproterone Acetate/Ethinyl Estradiol 
2/0.035mg

Prescription Required
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Prescription Required
Product of United Kingdom

Product of United Kingdom

Marketed as Co-Cyprindiol in United Kingdom.

Cyproterone Acetate/Ethinyl Estradiol 21 Day (generic Diane-35)

What are generics?

Cyproterone Acetate/Ethinyl Estradiol 
2/0.035mg

Prescription Required
Select Quantity
Prescription Required
Product of Canada

Product of Canada

Marketed as Ran-Cyproterone/Ethinyl Estradiol in Canada.

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Important information about Diane-35

Diane-35 contains cyproterone acetate, an anti-androgen and progestogen (progestin), and ethinyl estradiol, an estrogen. It works by blocking androgen receptors and reducing androgen production, which helps improve symptoms like excessive hair growth, oily skin, and acne. It also acts like a combined oral contraceptive by preventing ovulation and providing a contraceptive effect.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Diane-35. However, the following is a synopsis of the general guidelines for the use of Diane-35:

  • Take one tablet daily at the same time each day.
  • Take tablets for 21 consecutive days, followed by a 7-day break before starting the next blister pack.
  • Swallow tablets whole with water.
  • Continue taking the medication regularly to maintain its hormonal contraceptive and treatment of acne effects.
  • If you miss a dose of the hormone-containing beige tablets, take it as soon as you remember. If it is more than 12 hours late, contraceptive protection may be reduced, and additional contraception will be needed for 7 days to prevent pregnancy.
  • Diane-35 does not protect you against sexually transmitted diseases. Continue using barrier contraception during sexual activity to prevent transmission.

Some mild or common side effects of Diane-35 include:

  • Nausea.
  • Breast tenderness or breast pain.
  • Headache.
  • Mood changes.
  • Weight changes.
  • Breakthrough bleeding.
  • Skin color changes (chloasma).

Some individuals may experience serious side effects while using Diane-35. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Signs of a heart attack include chest pain, shortness of breath, and pain radiating to your shoulder, neck, or jaw.
  • Signs of a stroke include numbness on one side of your body, a severe headache, or trouble speaking.
  • Signs of a blood clot/venous thromboembolism (VTE), which include a deep vein thrombosis or pulmonary embolism. Symptoms include severe leg cramps, swelling or redness, chest pain, or a fast heart rate.
  • Signs of cancer include breast lumps/ pain, swollen lymph nodes, or unusual vaginal bleeding.
  • Signs of gallbladder disease include pain or tenderness in your stomach.
  • Severe allergic reaction presenting with swelling of the face, lips, tongue, or throat, hives, and trouble breathing.

Disclaimer: These are not all of the possible side effects of Diane-35. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Diane-35, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

  • Smoking.
  • Obesity.
  • Heart valve problems or coronary artery disease.
  • High blood pressure (hypertension), high cholesterol, or high triglycerides.
  • Liver disease.
  • Kidney disease.
  • Irregular menstrual cycle.
  • Diabetes.
  • Gallbladder problems.
  • Porphyria.
  • Systemic lupus erythematosus.
  • Hereditary angioedema.
  • Crohn’s or colitis.
  • Fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency.
  • Breast lumps, or abnormal imaging of the breasts.
  • Polycystic ovary syndrome.

  • Hypersensitivity to the active ingredients or to any of the excipients, such as lactose monohydrate, magnesium stearate, or povidone.
  • History of blood clots, stroke, thrombosis, or thromboembolic disorders.
  • Coronary artery disease or history of heart attack.
  • Migraine with aura.
  • Diabetes with vascular symptoms, severe hypertension, or severe dyslipidemia.
  • Clotting disorders.
  • Severe liver disease or liver tumors.
  • Known or suspected breast cancer.
  • Unexplained vaginal bleeding.
  • Pregnancy or breastfeeding.

Improvement in acne and other androgen-related conditions may take several months. Treatment should be continued as directed by your healthcare provider.

When Diane-35 is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Protease inhibitors such as ombitasvir, paritaprevir, ritonavir, and dasabuvir may increase liver enzyme levels and should not be used together.
  • Enzyme inducers (such as certain anticonvulsants or antibiotics) may reduce the effectiveness of hormonal contraceptives.
  • Enzyme inhibitors such as azole antifungals (itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice may increase the levels and side effects of Diane-35.
  • Etoricoxib may increase levels of estradiol.

Diane-35 tablets contain:

  • Cyproterone acetate 2 mg.
  • Ethinyl estradiol 0.035 mg.

It should be stored at room temperature, out of the reach of children and pets.

It is manufactured by Bayer.

Yes, it is available from many manufacturers of generic drugs.

Barring any of the above serious side effects or under the advice of your physician, do not stop taking Diane-35 suddenly. Your healthcare provider may recommend stopping after your symptoms have improved, usually after several treatment cycles.

No, this is a birth control pill that cannot be taken during pregnancy.

Because it contains estrogen, Diane-35 may reduce breast milk production and pass into breast milk.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Diane-35 from UniversalDrugstore™

We ship to destinations within the United States, including Alaska and Hawaii, as well as internationally. Delivery typically takes about 2 weeks for orders shipped within the U.S. and Canada, and about 4 weeks for international orders, depending on your location and customs processing.

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

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Medical Disclaimer

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.