Janumet XR(Sitagliptin Phosphate/Metformin Hydrochloride ER)
Please Note: Please note that this product comes as Sitagliptin Phosphate 100mg and Metformin Hydrochloride 1000mg as two separate tablets. You need to take one of each tablet to equal one dose. 168 tablets provide 84 days supply of medication.
Janumet XR Drug Information
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How Long Does It Take to Receive My Janumet XR Order?
You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.
Janumet XR Overview
Sitagliptin/metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.sitagliptin and metformin. Sitagliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.
Janumet XR Warnings
Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking Janumet XR for a short time. Ask your doctor or pharmacist for more details. Stop taking Janumet XR and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.
How to Use Janumet XR
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using sitagliptin/metformin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Janumet XR by mouth as directed by your doctor, usually once daily with a meal, preferably in the evening. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Drink plenty of fluids while taking Janumet XR unless otherwise directed by your doctor. The Dosage of Janumet XR is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start Janumet XR at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take Janumet XR regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended. Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).
Janumet XR Precautions
Before taking Janumet XR, tell your doctor or pharmacist if you are allergic to sitagliptin or metformin; or if you have any other allergies. Janumet XR may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Janumet XR, tell your doctor or pharmacist your medical history,kidney disease, severe breathing problems (such as obstructive lung disease, severe asthma), liver disease, a disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones). Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop Janumet XR for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcohol while taking Janumet XR because it can increase your risk of developing lactic acidosis, pancreatitis, and low blood sugar. High fever, "water pills" (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lactic acidosis. Stop taking Janumet XR and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing. Older adults may be more sensitive to the side effects of Janumet XR, especially low blood sugar or lactic acidosis. Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using Janumet XR. During pregnancy, Janumet XR should be used only when clearly needed. Discuss the risks and benefits with your doctor. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin). Metformin passes into breast milk. It is unknown if sitagliptin passes into breast milk. Consult your doctor before breast-feeding.
Janumet XR Misdose
If you miss a dose of Janumet XR, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Janumet XR Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Janumet XR Side Effects
What are Janumet XR side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Janumet XR may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Janumet XR as a result of an interaction with other medications.
Side Effects of Janumet XR
The side effects of Janumet XR may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Janumet XR. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Janumet XR may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Janumet XR, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Janumet XR.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Janumet XR, or any other medication, should contact their physician. General information about Janumet XR and the side effects associated with Janumet XR are described in the following:
Common Janumet XR Side Effects
- upper respiratory infection
- headache disorder
- vitamin B12 deficiency
- abdominal distension
- weight loss
Less Frequent Janumet XR Side Effects
- upper respiratory infection
- nail disorders
- skin rash
- flu-like symptoms
- acute abdominal pain
- headache disorder
- weight gain
Rare or Very Rare Janumet XR Side Effects
- hypoglycemic disorder
- lactic acidosis
- megaloblastic anemia
- acute respiratory distress syndrome
- hepatocellular damage
- cholestatic hepatitis
- hypoglycemic disorder
- Stevens-Johnson syndrome
- skin rash
- necrotizing pancreatitis
- cutaneous vasculitis
- acute renal failure
- acute pancreatitis
- exfoliative dermatitis
- bullous pemphigoid
- kidney disease with reduction in GFR
- heart failure
- acute abdominal pain
- abnormal hepatic function tests
- pruritus of skin
- back pain
- peripheral edema
- pain in extremities
Janumet XR Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Janumet XR when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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