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(Sodium Polystyrene Sulfonate)

The active ingredient in Kionex is sodium polystyrene sulfonate. Kionex (sodium polystyrene sulfonate) works by removing excess potassium from the body through the gastrointestinal tract. It is a cation-exchange resin that exchanges sodium ions for potassium ions in the colon. The bound potassium is then excreted in the faeces, which helps lower elevated blood potassium levels (hyperkalaemia) without being absorbed into the bloodstream.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Kionex. However, the following is a synopsis of the general guidelines for the use of Kionex:

• Kionex may be taken by mouth as a liquid or powder mixed with water or syrup.
• It may also be given as an enema, known as a cleansing enema, in certain situations.
• Do not heat Kionex or mix it with fruit juice that is high in potassium.
• If taken by mouth, follow with adequate fluids unless your healthcare provider tells you otherwise.
• Kionex should be taken exactly as prescribed, including the correct dose and timing.

Some mild or common side effects of Kionex seen in clinical trials as compared to placebo include:

• Constipation.
• Loss of appetite.
• Nausea.
• Vomiting.
• Mild stomach discomfort.
• Swelling or edema due to sodium retention.

Some individuals may experience serious side effects while using Kionex. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe constipation or bowel obstruction.
• Electrolyte imbalances such as hypokalemia, which may cause muscle weakness or irregular heartbeat.
• Serious allergic reactions, including rash or difficulty breathing.
• Intestinal necrosis or colitis, especially when used with sorbitol.

These are not all of the possible side effects of Kionex. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Kionex, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Bowel disease, bowel obstruction, or severe constipation.
• Gastroparesis or fecal impaction.
• Heart failure or hypertension, due to sodium content.
• A history of electrolyte imbalances.
• Kidney disease or hypovolemia.

Kionex should be used with caution, especially in patients at increased risk of bowel complications. Potassium levels and other electrolytes must be monitored regularly during treatment.

Kionex should not be used in patients with:

• Bowel obstruction.
• Severe constipation that has not been treated.
• Known hypersensitivity to sodium polystyrene sulfonate or any of its components.
• Your healthcare provider will decide if Kionex is safe for you based on your medical history.

Kionex does not lower potassium levels immediately. It may take several hours to days to see a reduction in potassium levels, depending on the dose, route of administration, and severity of hyperkalemia. Regular blood tests are needed to monitor response.

When Kionex is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Antacids such as aluminum hydroxide or calcium-containing products, which may alter electrolyte balance.
• Laxatives and magnesium hydroxide, which may increase the risk of bowel problems.
• Thyroxine, as Kionex may reduce its absorption.
• Other prescription drugs taken by mouth, as Kionex may bind them and reduce effectiveness.

Kionex is available as an oral powder and as a suspension for enema use. The dose depends on potassium levels, medical condition, and response to treatment.

It should be stored at room temperature, away from the reach of children or pets.

Kionex is manufactured by ANI Pharmaceuticals.

Yes. Sodium polystyrene sulfonate is the generic name for Kionex.

Do not stop taking Kionex without speaking to your healthcare provider. Stopping treatment too soon may cause potassium levels to rise again. Your provider will tell you when it is safe to discontinue use.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Your healthcare provider will weigh the benefits and potential risks before recommending Kionex.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. It is not known if Kionex passes into breast milk, and your healthcare provider will advise you on the safest option.