Lioresal

The active ingredient in Lioresal is baclofen, which is a muscle relaxant and antispastic medication. The exact mechanism of action is not completely understood, but it is thought to reduce spasticity by blocking certain nerve receptors that cause your muscles to tense or cramp up.

Intrathecal baclofen (Lioresal) is administered directly into the intrathecal space (the space surrounding the spinal cord), usually by a pump through a small tube (catheter).

Follow all directions provided by your doctor and read all documents carefully, including the full Prescribing Information, FDA-approved Product Labeling, Instructions for Use, and Medication Guide, before using Lioresal. However, the following is a synopsis of the general guidelines for the use of Lioresal:

• Lioresal is typically taken by mouth 3 times daily.
• Your provider will usually start at a low dose and gradually increase it based on how well it’s working for you and how well you are tolerating it.
• Mark your calendar for appointments with your prescriber, including refills for your medicine. This ensures that you are being carefully monitored and that you do not run out of oral baclofen (Lioresal), which can produce withdrawal symptoms such as muscle spasms, itching, and convulsions.

The most common side effects of Lioresal seen in clinical trials include:

• Sleepiness.
• Muscle weakness.
• Nausea and vomiting.
• Constipation.
• Dizziness.
• Dry mouth.
• Urinary retention.
• Sexual dysfunction.
• Memory impairment or confusion.

Some individuals may experience serious side effects while using Lioresal. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Taking too much Lioresal. Symptoms of overdose include tiredness, disorientation, decreased breathing, and seizures.
• Stopping Lioresal suddenly. Withdrawal symptoms include muscle spasms, itching, low blood pressure, a "pins and needles" sensation, hallucinations, and seizures.
• CNS depression. Symptoms include shallow or slow breathing, shortness of breath, dizziness, trouble staying awake, and confusion.
• Allergic reaction to the medication, such as hives, trouble breathing, and swelling of your face, tongue, and throat.
• Increased risk of developing an ovarian cyst.

These are not all of the possible side effects of Lioresal. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Lioresal, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• An allergy to baclofen.
• An infection.
• Epilepsy.
• Kidney disease.
• Consult your doctor before consuming alcohol or using other drugs or natural substances that slow your reactions.
• Do not use baclofen at a time when you need muscle tone for safe balance and movement during certain activities.

Hypersensitivity or adverse reactions to the medication.

Lioresal starts to work within a few hours but may take 3-4 days before muscle rigidity and stiffness subsides.

When Lioresal is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

Drinking alcohol or taking medications that can make you drowsy.

Medication for Parkinson’s disease.

Lioresal comes in several different dosage forms and strengths. This includes oral tablets, oral solutions, granules, and an intrathecal injection.

The normal dose can range from 5 mg to 20 mg by mouth, 3 times daily. The maximum dose is 20 mg 4 times daily.

Your dose may be changed if you have serious kidney issues.

Store at room temperature and keep out of reach of children.

Novartis is the company that manufactures Lioresal. Lioresal is a registered trademark of Amneal Pharmaceuticals.

Yes, there are generic versions of Lioresal tablets available.

Abrupt discontinuation can cause a severe withdrawal syndrome, and serious baclofen withdrawal symptoms include high fevers, changed mental status, and muscle stiffness.

You should not use Lioresal while pregnant unless your doctor tells you to. Tell your doctor if you are pregnant or plan to get pregnant. They will know or recommend what is best for you.

Lioresal is found in breast milk, but the effects are not known. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.