Mirapex

The active ingredient in Mirapex is pramipexole dihydrochloride. It belongs to a class of medications called nonergot dopamine agonists. Its mechanism of action involves binding to specific receptors to raise the activity of dopamine on the nerves in certain areas of the brain. This is thought to help improve movement problems for those with Parkinson's disease or restless legs syndrome.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Mirapex. However, the following is a synopsis of the general guidelines for the use of Mirapex:

• Take orally as directed by your physician with or without food. Take this medication with food if it upsets your stomach.
• Immediate-release tablets (Mirapex) are approved to treat either Parkinson's symptoms or RLS and are typically taken three times daily.
• Extended-release tablets (Mirapex ER) are only approved to treat Parkinson's symptoms and are typically taken once daily.
• Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not take double or extra doses.

The most common side effects of Mirapex seen in clinical trials as compared to placebo include:

• Constipation.
• Drowsiness.
• Dry mouth.
• Muscle weakness.
• Somnolence.
• Nausea.
• Trouble sleeping.

Some individuals may experience serious adverse reactions while using Mirapex. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reactions - skin rash, itching, hives, swelling.
• Increased incidence of intense urges (gambling, sexual, uncontrolled spending, binge eating).
• Orthostatic hypotension or low blood pressure - dizziness, lightheadedness, loss of balance, and falls.
• Severe muscle damage (rhabdomyolysis) - muscle pain, dark-colored urine, weakness, and tiredness.
• Confusion, hallucinations, depression, or other mood/behavior changes.
• Posture changes - worsening curve in the spine.
• Falling asleep during normal activities like driving.
• Uncontrollable movements.

These are not all of the possible side effects of Mirapex. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Mirapex, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart disease.
• Dyskinesia (trouble with muscle control).
• Hallucinations.
• Postural hypotension (lightheadedness when getting up suddenly from a lying or sitting position).
• Kidney disease.
• Sleep disorders.
• Sleepiness.
• Frequent alcohol consumption.
• Low blood pressure (Hypotension).
• Mental illness.
• Narcolepsy.
• On hemodialysis.
• Allergic reaction to pramipexole.
• Pregnant.
• Breastfeeding.

• Hypersensitivity/allergic reactions to pramipexole.
• Use with caution in patients with renal impairment.

Mirapex starts working in about 2 hours; that's why you should take it 2-3 hours before bedtime for restless legs. People taking Mirapex for Parkinson's disease usually notice a significant improvement in their symptoms in about 12-16 weeks.

When Mirapex is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Cimetidine.
• Metoclopramide.
• Mental illness medications (chlorpromazine, haloperidol).

Mirapex is available in the following dosage forms:

• Oral tablets - 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, and 1.5 mg.

Store at room temperature and keep out of reach of children.

Boehringer Ingelheim Pharmaceuticals Inc. is the pharmaceutical company that manufactures Mirapex.

There are lower-cost generics available for the brand name Mirapex.

Do not stop or adjust your use of this medication without first consulting with your doctor. Stopping your use of this medication suddenly can cause serious side effects as well as unpleasant withdrawal symptoms.

It is unknown whether Mirapex will harm an unborn baby. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown whether Mirapex passes into breast milk or if it could harm a nursing baby. it is not recommended to use this medication during lactation. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.