Pristiqand/or alternativesChemical Ingredient: Desvenlafaxine Succinate ER
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
- Manufactured by Wyeth
- Product of Australia • Shipped from Vanuatu
- Prescription Required
- Manufactured by Sun Pharma
- Product of India • Shipped from India
- Prescription Required
- Manufactured by Wyeth
- Product of Australia • Shipped from Vanuatu
- Prescription Required
- Manufactured by Torrent
- Product of India • Shipped from India
- Prescription Required
Pristiq Helps Treat the Following Conditions:
Major depressive disorder
Depression is a mood disorder that manifests in feelings of tiredness, loss of interest, sleep disturbances and anxiety. People usually have trouble carrying out everyday activities and may feel like life is not worth living. Depression may require long-term treatment involving medications and psychotherapy.
Generic Alternatives to Pristiq
The active ingredient in Pristiq is desvenlafaxine, which belongs to a class of substances known as serotonin-norepinephrine reuptake inhibitors. The exact mechanism of action is unknown but it is thought to restore the balance of the two neurotransmitters in the brain, alleviating depression and mood disorders.
Patients have a choice of buying brand name Pristiq or generic alternatives. A number of safe, affordable generic alternatives to Pristiq are available through our international online pharmacy.
Pristiq in the News
Mylan introduces Pristiq generic
In the United States, the pharmaceutical company Mylan has introduced desvenlafaxine extended-release tablets, a generic version of Pfizer's Pristiq. For the 12 month period ending January 31, 2017, the drug reached US sales of approximately US$853 million for the 12 months ending January 31, 2017.
The move follows the launch of a generic version of Pristiq by pharmaceutical company Teva Pharmaceuticals.
Eric Dane Is 'Feeling Great' After Taking Time Off to Cope with Depression
Actor Eric Dane has spoken candidly about his struggles with depression, which prompted him to take a break from the series The Last Ship.
Dane said he took time off and started therapy with Pristiq. The treatment appears to be working and the actor said he was feeling better.
Pristiq General Information
Pristiq is an antidepressant containing the active substance desvenlafaxine. It belongs to a class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It helps restore the balance of serotonin and norepinephrine in the brain, improving well-being, energy levels and mood.
Antidepressant medications provide a number of important benefits and can help alleviate problems such as suicidal thoughts. They are normally prescribed to patients with depression and mental or mood disorders.
However, in a small number of patients, certain antidepressants can worsen feelings of depression and suicidal thoughts. The likelihood of occurrence is higher in people under 25 years old. Before starting a treatment course, patients need to discuss all possible risks with their doctor.
Patients should immediately contact their doctor in the event they experience any unusual behavior such as suicidal thoughts, trouble sleeping, worsening anxiety or panic attacks.
Symptoms such as irritability, hostility, anger, impulsive actions, severe restlessness and very rapid speech should also be reported. Patients should be especially cautious at the time new medication is started or if the dose of a medication they are already taking has changed.
The information on this page is not a replacement for a consultation with a physician, qualified to treat this condition and prescribe medication. The information is supplied by a third party, independent from this website and only serves to raise awareness about this condition and point out basic information regarding treatment.
The website cannot take responsibility for the reliability or medical efficacy of the information provided. As mentioned above, patients should seek medical attention to ensure effective and safe treatment.
Not all products are shipped by our contracted Canadian pharmacy. The source country, shipping country or drug manufacturer may vary depending on availability.
The website also maintains commercial ties with dispensaries around the world. Products can be sourced from a number of countries. Patients should note that different items within an order can be shipped from different jurisdictions, depending on availability and cost at the time an order was placed.
How to Use Pristiq
Pristiq should be taken exactly as prescribed by a patient’s doctor, and the dosage depends on the patient’s condition and response to treatment. Most patients are prescribed one daily oral dose.
The time-release tablet should be swallowed whole. It should not be crushed, chewed or dissolved in water as this can cause the drug to release all at once, increasing the risk of negative side effects. Patients should not split tablets unless they use a score line and are expressly directed by their doctor or pharmacist to do so.
Some patients are told to start the medication at a low dose and increase it gradually. This is done to reduce the risk of negative side effects. Patients should follow their prescription strictly and take exactly the amount they have been prescribed. It is necessary to use Pristiq regularly in order to experience its full benefit. It may take several weeks for people to experience the full benefit of this medication.
Therapy should continue even if people feel well, and this medication can only be stopped following a consultation with the treating physician. Stopping the medication suddenly can cause symptoms such as headache, mood swings, sleep changes and brief sensations similar to electric shock. To prevent such symptoms, patients are directed to reduce their dose gradually, giving the body time to readjust.
Patients switching from another antidepressant to Pristiq should ask their doctor to slowly reduce the dose of their old medication in order to prevent withdrawal reactions.
Before starting treatment patients need to discuss the possibility of allergic reactions to desvenlafaxine or any of the medicine’s inactive ingredients. It is also vital to discuss the patient’s medical history, especially any personal or family history of bipolar disorder, manic-depressive disorder or suicide attempts.
Patients should alert their doctor if they – or anybody in their family – suffers from angle-closure glaucoma, as well as bleeding problems, high blood pressure, high cholesterol, kidney or liver disease. The treating physician needs to be notified if the patient has previously suffered a stroke or heart attack, has a seizure disorder or heart failure. Patients with hyponatremia, an electrolyte disbalance caused by a low amount of sodium in the blood should notify their physician before starting treatment with Pristiq or its generic alternatives.
This medication may cause blurred vision, dizziness or drowsiness. Patients should use caution when driving, using machinery, and performing activities which require alertness until the effects of the medication are known. Alcoholic beverages should be avoided.
Patients preparing for surgery or certain dental procedures should inform their doctor or dentist about all medicines, supplements and herbal products they are taking.
Older adults may be more sensitive to some of the side effects of this medication, particularly dizziness when standing up or bleeding sporadically. They are also more likely to develop hyponatremia, especially if they are taking diuretics. Older adults should be aware of an increased risk of falling, caused both by hyponatremia and dizziness.
Based on information for a similar drug, venlafaxine, children may be more sensitive to side effects, including loss of appetite and weight loss. Parents of children taking desvenlafaxine should regularly monitor height and weight.
This medication may harm an unborn baby. Pregnant women should discuss the risks and benefits of continuing therapy with their doctor. They should, however, not stop taking the medication unless directed by their doctor. In rare cases, babies born to mothers who used Pristiq in the last trimester may develop symptoms such as feeding or breathing difficulties, seizures, muscle stiffness or constant crying. Parents should contact a physician right away if they notice such symptoms in their newborn.
Desvenlafaxine is known to pass into breast milk in small amounts and, as a result, could negatively affect a nursing infant.
Patients who miss a dose of Pristiq should take it as soon as they remember. If this happens near the time for the next dose, patients should skip the missed dose and proceed as usual. Patients should not double up the dose in order to catch up.
Drug interactions can change the way Pristiq works and may increase the risk of side effects. Before starting treatment, patients need to discuss the full list of medications and supplements they are taking with their doctor. Patients should not change their dose or stop taking this medication unless their physician advises them to do so.
Some medicines may interact negatively with desvenlafaxine. This includes drugs that inhibit thrombus formation, such as clopidogrel, and "blood thinners" like dabigatran and warfarin.
Nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen can also have negative interactions
When coupled with desvenlafaxine, aspirin can increase the risk of bleeding. Some patients may be directed by their doctor to take daily low doses of aspirin (not higher than 325 milligrams) in order to prevent heart attack or stroke. Such patients can continue on as normal unless directed otherwise by their physician.
There is a risk of serious and possibly fatal interaction when desvenlafaxine is taken with MAO inhibitors. These drugs – including isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine – should not be taken together with desvenlafaxine. Most of the above-mentioned drugs should also not be taken for two weeks before the start of treatment, and at least a week after treatment with Pristiq.
Taking desvenlafaxine with other drugs that increase serotonin increases the risk of developing serotonin syndrome or serotonin toxicity, a potentially fatal condition. Drugs which may interact in this way include duloxetine, milnacipran, and tryptophan, as well as selective serotonin reuptake inhibitors like fluoxetine and paroxetine. Examples also include St John’s wort, as well as drugs like MDMA and ecstasy.
Patients should inform their doctor if they use other products which cause drowsiness, like alcohol or marijuana. Opioid pain and cough relievers like codeine and hydrocodone have the same effect, as do drugs for sleep and anxiety-like alprazolam, lorazepam, and zolpidem. Muscle relaxants like carisoprodol and cyclobenzaprine – as well as antihistamines like cetirizine and diphenhydramine – may also cause drowsiness. Patients should check the labels of all allergy and cough-and-cold products for ingredients that may cause drowsiness, and discuss the safe use of such products with their pharmacist.
Desvenlafaxine is similar to venlafaxine and the two medications should not be used together.
Patients should also be aware that this medicine may interact with certain lab tests, possibly causing false results. One example is the urine test for amphetamines.
Pristiq Side Effects
Side effects include drowsiness and dizziness, nausea, dry mouth, loss of appetite, weight loss or constipation. Some patients may also experience blurred vision, excessive sweating, trouble sleeping or nervousness.
Desvenlafaxine may cause high blood pressure, so patients should regularly monitor this and alert their doctor if their blood pressure is high.
Some patients may experience empty tablet shells appearing in their stool. This is not a cause for concern.
Most people use this medication safely. However, patients should immediately report serious side effects like severe headache, tremors, decreased libido and changes in sexual function, as well as easy bruising or bleeding.
Patients should seek immediate medical attention in the event they experience symptoms like shortness of breath, chest pain, persistent cough, black stools or vomit that looks like coffee grounds. Serious side effects include eye pain, swelling or redness, widened pupils and seizures. The treating physician should also be immediately notified if the patient experiences vision changes such as seeing rainbows around lights at night.
In rare cases, desvenlafaxine may cause serotonin syndrome – a very serious condition. The risk is higher for people already taking other drugs that increase serotonin. People who experience fast heartbeat, loss of coordination, severe dizziness and hallucinations should seek immediate medical help. Symptoms like severe nausea or diarrhea, twitching muscles, unexplained fever and unusual agitation should also be reported immediately.
Serious allergic reactions to Pristiq are rare, yet patients should be aware of allergy symptoms such as rash, itching and swelling, severe dizziness and trouble breathing.
Pristiq should be stored at room temperature away from light or moisture. Do not store in the bathroom. Keep away from children and pets.
Unwanted medication should be disposed of properly and should not be poured into drains or flushed down the toilet. Patients should consult a pharmacist or their local waste disposal company to find out more about safe disposal methods.
Pristiq Drug Information
Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
How to Use Pristiq
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking desvenlafaxine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Pristiq by mouth with or without food as directed by your doctor, usually once daily. The Dosage of Pristiq is based on your medical condition and response to treatment. Do not crush, chew, or dissolve Pristiq in water. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. To reduce your risk of side effects, your doctor may direct you to start Pristiq at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Do not increase your dose or use Pristiq more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Use Pristiq regularly to get the most benefit from it. To help you remember, use it at the same time each day. It is important to continue taking Pristiq even if you feel well. Do not stop taking Pristiq without consulting your doctor. Some conditions may become worse when Pristiq is suddenly stopped. Also, you may experience symptoms such as mood swings, headache, tiredness, sleep changes, and brief feelings similar to electric shock. To prevent these symptoms while you are stopping treatment with Pristiq, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away. If you are switching from another antidepressant to desvenlafaxine, your doctor should slowly reduce the dose of your old antidepressant to prevent withdrawal reactions from the other antidepressant. Ask your doctor or pharmacist for more details. It may take several weeks before you get the full benefit of Pristiq. Tell your doctor if your condition does not improve or if it worsens.
Before taking desvenlafaxine, tell your doctor or pharmacist if you are allergic to it; or to venlafaxine; or if you have any other allergies. may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Pristiq, tell your doctor or pharmacist your medical history,personal or family history of psychiatric disorders (such as bipolar/manic-depressive disorder), personal or family history of suicide attempts, bleeding problems, personal or family history of glaucoma (angle-closure type), high blood pressure, heart problems (such as chest pain, heart failure, heart attack), history of stroke, high cholesterol, kidney disease, liver disease, seizure disorder, low sodium in the blood (hyponatremia). Pristiq may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Pristiq, especially dizziness when standing and bleeding. Older adults are also more likely to develop a type of mineral imbalance (hyponatremia), especially if they are also taking water pills (diuretics) with Pristiq. Dizziness and mineral imbalance can increase the risk of falling. Based on information for a similar drug (venlafaxine), children may be more sensitive to the side effects of Pristiq, especially loss of appetite and weight loss. Monitor height and weight in children who are taking Pristiq. Consult your doctor or pharmacist for more details. During pregnancy, Pristiq should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used Pristiq during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly. Since untreated mental/mood problems (such as depression, anxiety, and panic attacks) can be a serious condition, do not stop taking Pristiq unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using Pristiq during pregnancy. Pristiq passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
If you miss a dose of Pristiq, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, blood thinners such as dabigatran/warfarin). Aspirin can increase the risk of bleeding when used with Pristiq. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details. Taking MAO inhibitors with Pristiq may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with Pristiq. Most MAO inhibitors should also not be taken for two weeks before and at least 7 days after treatment with Pristiq. Ask your doctor when to start or stop taking Pristiq. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including other SNRIs such as duloxetine/milnacipran, SSRIs such as fluoxetine/paroxetine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Desvenlafaxine is very similar to venlafaxine. Do not use medications containing venlafaxine while using desvenlafaxine. Pristiq may interfere with certain lab tests (including urine tests for amphetamines), possibly causing false test results. Make sure lab personnel and all your doctors know you use Pristiq.
Pristiq Side Effects
Drowsiness, dizziness, nausea, dry mouth, constipation, loss of appetite, weight loss, blurred vision, nervousness, trouble sleeping, or excessive sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Pristiq may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. An empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the medication. Remember that your doctor has prescribed Pristiq because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Pristiq do not have serious side effects. Tell your doctor right away if you have any serious side effects,severe/pounding headache, shakiness (tremor), decreased interest in sex, changes in sexual ability, easy bruising/bleeding. Get medical help right away if you have any very serious side effects,cough that doesn't go away, shortness of breath, chest pain, black stools, vomit that looks like coffee grounds, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night), seizures. Pristiq may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section).fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. A very serious allergic reaction to Pristiq is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List of Pristiq side effects
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.