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The active ingredient in Replens is polycarbophil, depending on the formulation. Some products may also contain moisturizing ingredients such as glycerin, mineral oil, or hyaluronic acid.

Replens works by attaching moisture to the vaginal lining and helping maintain hydration over time. The moisturizer gel helps restore moisture balance and improve comfort by supporting natural lubrication. Unlike some personal lubricant products that provide short-term relief only during intimacy, Replens vaginal moisturizer is designed to provide longer-lasting moisture with regular use.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Replens. However, the following is a synopsis of the general guidelines for the use of Replens:

• Wash your hands before and after using the product.
• Use the vaginal moisturizer exactly as directed on the package.
• Insert the moisturizer gel into the vagina using the pre-filled applicators or reusable applicator provided.
• Replens Long-Lasting Vaginal Moisturizer is often used every 3 days or as recommended.
• Personal lubricant products may be applied before sexual activity as needed.
• Do not use more than directed unless instructed by a healthcare provider.
• Stop use and seek medical advice if irritation worsens or does not improve.
• Avoid sharing applicators with other individuals.

Some mild or common side effects of Replens seen in clinical trials include:

• Mild vaginal irritation.
• Temporary burning or itching.
• Increased vaginal discharge.
• Pelvic discomfort.
• Mild cramping.

Some individuals may experience serious side effects while using Replens. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction.
• Swelling or severe irritation.
• Severe vaginal pain.
• Signs of infection, such as fever or unusual discharge.

These are not all of the possible side effects of Replens. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Replens, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Vaginal bleeding of unknown cause.
• Severe pelvic pain.
• Frequent urinary tract infections or bacterial vaginosis.
• A history of allergic reactions to feminine care or personal care products.
• Pregnancy or breastfeeding concerns.
• Additional precautions include:
• Replens is for vaginal use only.
• Avoid contact with the eyes.
• Stop use if severe irritation develops.
• Some products may contain ingredients such as mineral oil or silicone that may not be compatible with certain latex products.
• Keep out of the reach of children.

Replens should not be used by individuals with known hypersensitivity or allergic reaction to any ingredient in the formulation.

Some people notice improved hydration and comfort within hours after application. With regular use, vaginal dryness symptoms may continue improving over several days. Long-lasting vaginal moisturizer products are designed to provide relief for multiple days between applications.

When Replens is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other vaginal products, which may increase irritation when used together.
• Spermicides or certain feminine care products, which may affect comfort or product performance.
• Silicone lubricant or personal lubricant products, which may alter texture or effectiveness if combined.

Replens products are available in several formulations, including:

• Replens Long-Lasting Vaginal Moisturizer.
• Replens Silky Smooth Lubricant.
• Comfort gel formulations.
• Moisturizer gels with pre-filled applicators.

It should be stored at room temperature, away from the reach of children or pets.

Replens products are manufactured by Church & Dwight Co., Inc.

There is no exact generic version of Replens. However, similar vaginal moisturizers and lubes may be available from other manufacturers.

Replens can generally be stopped at any time. However:

• Vaginal dryness symptoms may return after stopping use.
• Regular use may help maintain hydration and comfort.
• Speak with your healthcare provider if symptoms continue or worsen.

Limited information is available regarding use during pregnancy. A healthcare provider can help determine if use is appropriate.

Replens is generally considered low risk during breastfeeding because it works locally and is hormone-free.