Rifaterand/or alternativesChemical Ingredient: Isoniazid/Rifampin/Pyrazinamide
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
No generic is available for Rifater 50/120/300mg.
- Manufactured by Sanofi Aventis
- Product of United Kingdom • Shipped from United Kingdom
- Prescription Required
No generic is available for Rifater 50/120/300mg.
Rifater Drug Information
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Rifater Drug Information
Rifater is used to treat tuberculosis (TB) of the lungs.rifampin, isoniazid, and pyrazinamide. These medications are antibiotics. Rifampin is known as a rifamycin antibiotic. Rifater works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Isoniazid has rarely caused very serious (possibly fatal) liver disease. The risk of liver disease is increased in people who are 35 years and older, who use alcohol or illegal injection drugs, or who currently have long-term liver problems. Tell your doctor right away if you develop symptoms of liver disease, including persistent nausea/vomiting, severe stomach/abdominal pain, unusual weakness/tiredness, dark urine, yellowing eyes/skin. Your doctor should order liver function tests while you are taking Rifater. Keep all medical and laboratory appointments.
How to Use Rifater
Take Rifater by mouth 1 hour before or 2 hours after a meal, usually once daily or as directed by your doctor. Take it with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you also take antacids, take Rifater at least 1 hour before the antacid. The Dosage of Rifater is based on your age, weight, medical condition, and response to treatment. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take Rifater at the same time(s) every day. Continue to take Rifater (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant). Your doctor may also direct you to take vitamin B6 (pyridoxine) to help prevent certain side effects (such as nerve problems) from isoniazid. Follow your doctor's instructions carefully. Isoniazid may interact with foods containing tyramine/histamine (such as cheese, red wine, certain types of fish). This interaction may cause increased blood pressure, flushing of the skin, headache, dizziness, or fast/pounding heartbeat. Tell your doctor right away if any of these symptoms occur. Your doctor may recommend that you follow a special diet while taking Rifater. Consult your doctor for more details. Tell your doctor if your condition persists or worsens.
Before taking Rifater, tell your doctor or pharmacist if you are allergic to rifampin, isoniazid, or pyrazinamide; or to other rifamycins (such as rifabutin, rifapentine); or if you have any other allergies. Rifater may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Rifater, tell your doctor or pharmacist your medical history,previous severe reaction from isoniazid (such as liver disease), liver disease, kidney disease, alcohol use, HIV infection, diabetes, gout, high uric acid level in the blood, numbness/tingling of arms/legs (peripheral neuropathy), recent childbirth, a certain blood disorder (porphyria). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using Rifater. Rifater may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using Rifater unless your doctor tells you to. During pregnancy, Rifater should be used only when clearly needed. When rifampin is taken during the last few weeks of pregnancy, the risk of bleeding in both mother and infant may be increased. Tell your doctor right away if you notice any bleeding in your newborn. Discuss the risks and benefits with your doctor. Rifater passes into breast milk but the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before breast-feeding.
For the best possible benefit, it is important to take each scheduled dose of Rifater as directed. If you miss a dose of Rifater, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.acetaminophen, carbamazepine, disulfiram, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), SSRI antidepressants (such as fluoxetine, sertraline), valproic acid. Rifampin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include digoxin, nimodipine, phenytoin, ranolazine, praziquantel, tacrolimus, theophylline, certain anti-infectives (e.g., chloramphenicol, clarithromycin, dapsone, doxycycline, linezolid, telithromycin, zidovudine, quinolones such as ciprofloxacin), azole antifungals (such as itraconazole, ketoconazole), "blood thinners" (such as warfarin), calcium channel blockers (such as diltiazem, verapamil), HIV NNRTIs (such as delavirdine, etravirine, nevirapine), HIV protease inhibitors (such as atazanavir, ritonavir, saquinavir), among others. Rifater may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using Rifater. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Rifater may interfere with certain laboratory tests (including folate/vitamin B12 levels, urine glucose/ketone tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Rifater.
Rifater Side Effects
Nausea/vomiting, upset stomach, heartburn, mild muscle/joint pain, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Rifater may cause urine, sweat, saliva, or tears to change color (yellow, orange, red, or brown). This effect is harmless and will go away when the medication is stopped. However, teeth and contact lens staining may be permanent. Remember that your doctor has prescribed Rifater because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Rifater do not have serious side effects.numbness/tingling of arms/legs, painful/swollen joints.signs of kidney problems (such as change in the amount of urine, bloody urine), increased thirst/urination, vision changes, fast heartbeat, easy bruising/bleeding, mental/mood changes (such as confusion, psychosis), seizures. Rifater may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse.persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool. A very serious allergic reaction to Rifater is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List of Rifater side effects
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Rifater when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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