Zelaparand/or alternativesChemical Ingredient: Selegiline Hydrochloride ODT
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
1.25mg Orally Disintegrating Tablets
No generic is available for Zelapar 1.25mg.
- Manufactured by Cephalon Ltd
- Product of United Kingdom • Shipped from United Kingdom
- Prescription Required
No generic is available for Zelapar 1.25mg.
Zelapar Drug Information
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Zelapar Drug Information
Zelapar is used with levodopa/carbidopa to treat movement disorders caused by Parkinson's disease. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle stiffness, and sudden switching between normal movement and stiffness ("on-off" problems). It may improve your range of motion and ability to walk, dress, and exercise. Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain natural substances in the brain (neurotransmitters such as dopamine, norepinephrine, and serotonin).
How to Use Zelapar
Take Zelapar by dissolving the tablet on the tongue, usually once a day in the morning or as directed by your doctor. Do not swallow the tablet or the dissolved medication with saliva or water. It should be absorbed through the lining of the mouth. To prevent accidentally swallowing any of the medication, do not eat or drink anything for at least 5 minutes before or after using Zelapar. Dry your hands before peeling back the foil on the blister pack to carefully remove a tablet. Do not push the tablet through the foil. Immediately place the tablet on the tongue and allow it to dissolve completely. Do not crush, split, or break the tablet before taking it. Do not remove the tablet from the blister pack until just before taking. Taking selegiline late in the day may cause trouble sleeping. Dosage of Zelapar is based on your medical condition and response to therapy. Your doctor may change your dose to find the best dose for you. Do not increase your dose or take it more often than directed. Your doctor may direct you to lower your levodopa dose if you are having more side effects while using selegiline. Follow your doctor's instructions closely. Do not stop or change the dose of any of your medications without first talking with your doctor. Use Zelapar regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not stop taking Zelapar without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. It may take a few weeks for the full benefits of the drug to be noticed. Talk with your doctor if the medication stops working well or if your condition worsens.
Before taking selegiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Zelapar may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Zelapar, tell your doctor or pharmacist your medical history,a certain kind of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), heart problems (e.g., congestive heart failure, heart attack), bleeding problems, peptic ulcer, history of severe/frequent headaches, diabetes, personal/family history of mental/mood disorders (e.g., schizophrenia, bipolar disorder), personal/family history of high blood pressure, kidney disease, liver disease, overactive thyroid (hyperthyroidism). Zelapar may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). See also Side Effects section. To minimize dizziness and the risk of fainting, get up slowly when rising from a sitting or lying position. Before having surgery, tell your doctor or dentist you are taking Zelapar. You may need to stop taking Zelapar beforehand. Follow your doctor's instructions carefully. This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using Zelapar safely. The elderly may be more sensitive to the effects of Zelapar, especially dizziness from low blood pressure. During pregnancy, selegiline should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if Zelapar passes into breast milk. Consult your doctor before breast-feeding.
If you miss a dose of Zelapar, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.antidepressants (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, tranylcypromine), appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, buspirone, carbamazepine/oxcarbazepine, cyclobenzaprine, deutetrabenazine, certain herbal products (such as ephedra/ma huang), cold medications/nasal decongestants (such as phenylephrine, phenylpropanolamine, pseudoephedrine), fentanyl, street drugs (such as LSD, mescaline), stimulants (such as amphetamines, ephedrine), supplements (such as tryptophan, tyramine), tetrabenazine, certain "triptans" used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan), valbenazine. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, dextromethorphan, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine, TCAs such as amitriptyline/doxepin), certain narcotic medications (such as meperidine, methadone, pentazocine, propoxyphene, tramadol, tapentadol), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Tell your doctor or pharmacist if you are using any of these medications before, during, or within 2 weeks after treatment with selegiline. Tell your doctor or pharmacist if you have taken fluoxetine during at least 5 weeks before starting selegiline. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking selegiline. Check the labels on all your medicines (such as allergy, cough-and-cold products, diet pills) because they may contain dextromethorphan, decongestants, or stimulants. Ask your pharmacist about the safe use of those products. To prevent a very serious high blood pressure reaction, it is very important that you do not increase your dose. Follow any special diet your doctor or dietician recommends in order to limit your intake of tyramine while you are taking this medicine. If your doctor recommends a special diet,aged cheeses (e.g., bleu, cheddar, parmesan), dried/aged/fermented meats and sausages (e.g., salami, liverwurst), preserved fish (e.g., pickled herring), products containing large amounts of yeast (e.g., concentrated yeast extract, bouillon cubes, powdered soup/gravy, homemade or sourdough bread), fermented foods (e.g., sauerkraut, kim chee), most soybean products (e.g., soy sauce, tofu), broad/fava beans, red wine, sherry, tap beers, vermouth.avocados, bananas, eggplant, green beans, raisins, raspberries, red plums, spinach, tomatoes, chocolate, cultured dairy products (e.g., buttermilk, yogurt, sour cream), fish eggs, pate, peanuts, coffee, cola, alcohol-free beer, bottled beer, distilled spirits, port, white wine. Consult your doctor or dietician for more details and a complete list of other tyramine-containing foods. Seek immediate medical attention if you notice symptoms of very high blood pressure such as unusually fast/slow heartbeat, vomiting, unexplained sweating, headache, chest pain, sudden vision changes, weakness on one side of the body, slurred speech. Zelapar may interfere with certain medical/laboratory tests (including brain scan for Parkinson's disease), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Zelapar.
Zelapar Side Effects
What are Zelapar side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Zelapar may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Zelapar as a result of an interaction with other medications.
Side Effects of Zelapar
The side effects of Zelapar may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Zelapar. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Zelapar may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Zelapar, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Zelapar.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Zelapar, or any other medication, should contact their physician. General information about Zelapar and the side effects associated with Zelapar are described in the following:
Common Zelapar Side Effects
- altered mental status
- mood changes
- abdominal pain with cramps
- skin rash
Less Frequent Zelapar Side Effects
- general weakness
- headache disorder
- mouth irritation
Rare or Very Rare Zelapar Side Effects
- suicidal ideation
- tardive dyskinesia
- extrapyramidal disease
- sinus bradycardia
- cardiac arrhythmia
- orthostatic hypotension
- gastrointestinal hemorrhage
- benign prostatic hyperplasia
- peripheral edema
- severe headache disorder
- drug-induced psychosis
- symptoms of anxiety
- false sense of well-being
- blurred vision
- skin photosensitivity
- back pain
- limb pain
- memory impairment
- athetoid movements
- head sensation disturbance
- weight loss
- increased urinary frequency
- impulse control disorder
- sudden onset of sleep
Store the blister packets in the pouch provided. Store at room temperature away from light and moisture. Keep all medications away from children and pets. Discard any remaining tablets in the blister packets 3 months after opening the pouch . The medication may no longer work 3 months after the pouch is first opened. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Zelapar when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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