How do you give an Invega injection?

Invega injections are available as Sustenna (monthly), Trinza (every 3 months), and Hafyera (every 6 months). All are for intramuscular use only and must be administered by a healthcare professional.

Invega Sustenna (paliperidone palmitate)

• Use the prefilled syringe kit with two safety needles
• Shake vigorously for at least 10 seconds to mix the suspension
• Select needle length based on injection site (deltoid or gluteal) and patient weight
• Administer as a single, slow intramuscular injection into the deltoid or gluteal muscle
• Oral antipsychotics can be tapered off after starting Sustenna

Invega Trinza (paliperidone palmitate)

• Only start after at least 4 months of Sustenna, with the last two maintenance doses identical
• Hold syringe tip pointing up and shake loosely for 15 seconds
• Choose needle length for deltoid or gluteal based on patient weight
• Inject slowly as a single intramuscular dose into the deltoid or gluteal muscle

Invega Hafyera (paliperidone palmitate)

• Requires prior treatment: either four months of Sustenna (last two doses 156 mg or 234 mg) or one full Trinza cycle (546 mg or 819 mg)
• With cap on, shake syringe tip pointing up quickly for 15 seconds, rest, then shake another 15 seconds
• Intended for gluteal intramuscular injection only
• Inject deeply and slowly into the muscle, avoiding blood vessels

Important notes

• All formulations are intramuscular only
• Do not administer by any other route
• Refer to full prescribing information for handling missed doses and storage

Sources

• Invega Sustenna, Trinza, Hafyera prescribing information (Janssen Pharmaceuticals)
• FDA label for paliperidone palmitate extended‐release injections

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