How long does Activella take to work?
Activella is a brand-name combination medication containing a progestin (norethindrone acetate) and an estrogen (estradiol). It is used to treat symptoms of low estrogen levels, such as night sweats, hot flashes, and vaginal dryness in postmenopausal women. It can also be used to prevent bone loss (osteoporosis) in women who have reached menopause.
Everyone’s experience of taking Activella will be different. While you may start feeling a difference within a few days or weeks, it typically takes longer for it to achieve its full effects. In a 12-week randomized clinical trial, Activella 1.0 mg/0.5 mg was compared to 1 mg of estradiol and to placebo. The average number and intensity of hot flushes were significantly reduced from baseline to week 4 and week 12 in those taking Activella when compared to placebo. For some people, however, it may take up to 3 months for them to see a significant improvement in their menopause symptoms.
Activella FAQs
How does Activella work?
Activella is a combination hormone replacement therapy (HRT) containing norethindrone acetate and estradiol…
What are the side effects of Activella?
Common side effects
- Breast pain or tenderness
- Headache
- Upper respiratory infection
- Postmenopausal bleeding
- Nausea
- Weight gain
- Back pain
Other possible side effects
- Bloating
- Fatigue
- Dizziness
- Hair loss
- Increased blood sugar
Serious side effects
- Heart attack or stroke risk
- Blood clots
- Allergic reactions
- Ovarian or breast cancer
- Liver problems
- Fluid retention
What drug interactions are there with Activella?
- CYP3A4 inducers (e.g., St. John’s Wort, carbamazepine)
- CYP3A4 inhibitors (e.g., erythromycin, grapefruit juice)
Boxed Warning
Smoking increases the risk of serious cardiovascular side effects with Activella. It should not be used in women over 35 who smoke. It is also not intended for prevention of cardiovascular disease or dementia.
What should your healthcare provider know before starting Activella?
- If you smoke
- Have a history of heart, liver, or kidney disease
- Have high cholesterol or had a hysterectomy
- Have cancer or are breastfeeding
How do you use Activella?
Take one Activella tablet by mouth once daily, with or without food, at the same time each day.
How do you store Activella?
Store at room temperature around 77°F (25°C). Keep out of reach of children.
Does Activella cause weight gain?
Weight gain may occur and can be due to fluid retention. Consult your provider for any unusual swelling.
When is the best time to take Activella?
Any time of day, but consistently. Take with food if it upsets your stomach.
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