How much water should you drink when taking farxiga?

Farxiga (dapagliflozin) is an SGLT2 inhibitor used for type 2 diabetes, heart failure, and chronic kidney disease. It promotes glucose excretion in urine, which also increases fluid loss. Adequate hydration is essential to prevent dehydration and support kidney and cardiovascular health.

Why hydration matters on Farxiga

• Increases urination, leading to fluid and electrolyte loss
• Reduces risk of dehydration, hypotension, acute kidney injury
• Helps prevent urinary and genital infections by maintaining urine flow
• Supports glycemic control and blood pressure management

Signs of dehydration

• Mild–moderate: thirst, dry mouth, dark urine, dizziness, fatigue, headache
• Severe: minimal urination, sunken eyes, rapid heartbeat, confusion, fainting

Daily water intake recommendations

No Farxiga‑specific guidelines exist. General targets:

• Women: ~9 cups (2.1 L) per day
• Men: ~13 cups (3.1 L) per day

Adjust based on:

• Age, body size, activity level, climate
• Concomitant diuretics or low‑sodium diet
• Heart failure or advanced kidney disease (may require restriction)
• Pregnancy, breastfeeding (may require increase)

Tips to stay hydrated

• Carry a marked water bottle to track intake
• Avoid excess caffeine and alcohol, which promote diuresis
• Eat water‑rich foods: watermelon, cucumbers, strawberries, celery
• Add slices of lemon or berries for flavor
• Set phone reminders or use a hydration app
• Monitor urine color—aim for pale yellow

Other Farxiga considerations

• Common side effects: urinary tract infections, genital yeast infections, frequent urination, dehydration
• Serious risks: acute kidney injury, hypotension, Fournier’s gangrene
• Report symptoms such as dizziness, lightheadedness, scant urine, or rapid heartbeat to your provider

Summary

While on Farxiga, aim for at least the usual daily water recommendations, adjusting up or down per your health status and lifestyle. Maintaining hydration helps prevent complications and supports the medication’s benefits. Consult your healthcare provider for a personalized fluid plan and report any signs of dehydration promptly.

Sources

• Farxiga (dapagliflozin) tablets [package insert]. AstraZeneca. 2022. Accessed Apr 21, 2025.
• How much water do you need? Academy of Nutrition and Dietetics. Accessed Apr 21, 2025.
• Dehydration: Signs, Symptoms, and Effects. WebMD. Accessed Apr 21, 2025.