Is Xofluza covered by insurance

Key Takeaways
- Many insurance plans, including Medicare and Medicaid, provide at least partial insurance coverage for Xofluza, but this varies widely by insurer and plan type.
- Xofluza is a brand-name, FDA-approved prescription drug, so costs may be higher than generic flu treatments like oseltamivir (Tamiflu).
- Manufacturer savings programs and Xofluza coupons from Genentech can lower out-of-pocket costs for eligible patients.
- Whether Xofluza is covered may depend on your flu treatment needs, medical conditions, patient eligibility, and whether you are considered high risk for flu complications.
- A healthcare provider or healthcare professional can help determine whether Xofluza is appropriate for you and guide you in navigating insurance questions.
What Is Xofluza?
Xofluza, the brand name for baloxavir marboxil, is approved by the U.S. Food and Drug Administration (FDA) to treat uncomplicated influenza virus A and B infections in adults and adolescents who are 12 years of age and older. It is a polymerase acidic (PA) endonuclease inhibitor that works differently from older flu medications like Tamiflu (oseltamivir) and is given as a single-dose treatment.
Xofluza is often chosen because:
- It reduces flu symptoms more quickly when taken early.
- It helps stop viral replication.
- It can be used for post-exposure prophylaxis after close contact with someone with the flu.
While Xofluza can treat the flu virus, it does not prevent bacterial infections that may happen with the flu.
Is Xofluza Covered?
In most cases, yes, but not always fully.
Insurance coverage for Xofluza varies depending on:
- Your insurance company.
- Whether you have commercial insurance, Medicare, or Medicaid.
- Your plan’s formulary (the list of covered medications).
- Whether the medication requires prior authorization.
- Your individual out-of-pocket cost structure.
Since Xofluza is a brand-name antiviral and newer than Tamiflu, some plans may:
- Cover it with higher copays.
- Require step therapy (trying generic drugs like oseltamivir first).
- Require specific documentation of medical conditions or high-risk status.
It is always best to contact your insurer directly or check their formulary for accurate information.
Commercial Health Insurance
Most private health insurance plans list Xofluza as a covered antiviral for flu treatment, especially during flu season. However:
- Copays may vary.
- Some plans may prefer generic oseltamivir.
- Some insurers may require clinical justification before they cover it.
Plans that use tiered coverage may place Xofluza on a higher (more expensive) tier due to its brand-name status.
Medicare Coverage
Xofluza may be covered under:
- Medicare Part D (drug coverage plan).
- Medicare Advantage plans with prescription benefits.
Medicaid Coverage
Medicaid programs vary by state, but many states do cover Xofluza. Some may require:
- Prior authorization.
- Documentation of high-risk conditions.
- Trial of oseltamivir before approval.
What About Self-Pay?
If you do not use insurance or if your plan does not cover Xofluza, you may pay the full retail price, which can vary but is typically higher than generic flu antivirals. This is why many people look for:
- Xofluza coupons.
- Manufacturer savings programs.
- Pharmacy discount programs.
Manufacturer Savings Programs
Genentech offers savings options for eligible commercially insured patients, which can significantly reduce the out-of-pocket cost of a Xofluza prescription. These savings do not apply to Medicare or Medicaid patients due to federal regulations.
Why Insurance Coverage Varies
Coverage may depend on:
- Whether your insurer views Xofluza as first-line or second-line therapy.
- Availability of lower-cost options like Tamiflu.
- Evidence from clinical trials.
- Formulary rules during flu season.
- Concerns about resistance to antiviral medications.
Some insurers prioritize medications that have been available longer, such as oseltamivir, which is available generically.
When Xofluza May Be Preferred
Insurance coverage is more likely when:
- You are considered high risk (older age, chronic illnesses, weakened immune system).
- You need post-exposure prophylaxis.
- You cannot tolerate oseltamivir or have had a previous allergic reaction to it.
- Your healthcare provider documents medical justification.
Does Insurance Cover Xofluza If You’re Breastfeeding or Pregnant?
Coverage is usually unrelated to pregnancy or breastfeeding, but whether you should take Xofluza depends on:
- Your health.
- Flu severity.
- A healthcare provider’s clinical judgment.
Always seek medical advice before taking antivirals during pregnancy or breastfeeding.
What Determines Your Copay?
It may depend on:
- Deductibles.
- Drug formulary tier.
- Whether Xofluza is classified as a preferred antiviral.
- Local pharmacy choice.
Some plans may include antiviral drugs in preventive medicine categories during peak flu season, lowering copays.
Does Insurance Cover Xofluza for Children?
Xofluza is approved for children 12 years of age and older. Insurance plans typically follow FDA age guidelines when determining approval and coverage.
Side Effects of Xofluza and Why They Matter to Insurance
While side effects such as diarrhea, sinusitis (swelling in the sinuses), headache, nausea, and bronchitis (inflammation of the airways to lungs) are generally mild, insurance companies may consider overall safety data, serious side effects, and cost-effectiveness when choosing preferred treatments.
Drug Interactions May Affect Whether Xofluza Is Appropriate
Xofluza should not be taken with:
- Antacids
- Calcium
- Laxatives containing minerals
- Dairy products
- Certain supplements
These interfere with absorption and may reduce effectiveness. Insurers may highlight these issues in their coverage policies.
Bottom Line
Yes, many insurance plans cover Xofluza, but your individual copay, approval, and requirements depend on your specific plan. Coverage is more likely if:
- You are in a high-risk category.
- Your doctor documents a medical need.
- Your plan includes brand-name antiviral drugs.
If you’re unsure whether Xofluza is covered, contact your insurer, ask your pharmacist to check, or speak with your healthcare provider for additional information.
FAQs
Does insurance cover Xofluza more than Tamiflu?
Usually, no. Tamiflu (oseltamivir) is available in a generic and often preferred, but Xofluza may still be covered with higher copays.
Is Xofluza covered under Medicare Part D?
Often yes, but coverage varies by plan. Check your formulary.
What if my plan doesn’t cover Xofluza?
Ask about Xofluza coupons, manufacturer savings, or discuss alternatives with your provider. You can also check UDS, where you may save up to 80% off your prescription.
Sources
- Xofluza (baloxavir marboxil) Prescribing Information. Genentech. Accessed Dec.15, 2025.