Aldactazide

(Spironolactone/Hydrochlorothiazide)

The active ingredients in Aldactazide are spironolactone and hydrochlorothiazide.

Spironolactone is considered a potassium-sparing diuretic or aldosterone receptor antagonist. It blocks aldosterone, a hormone that causes the body to retain salt and water, while helping the body keep potassium. Hydrochlorothiazide is a thiazide diuretic that increases the excretion of excess salt and water through the kidneys. Together, they reduce fluid buildup, lower blood pressure, and help balance potassium levels more effectively than either drug alone.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Aldactazide. However, the following is a synopsis of the general guidelines for the use of Aldactazide:

• Aldactazide is taken by mouth, usually once or twice daily, depending on the prescribed dose.
• It may be taken with or without food, but taking it at the same time each day can help maintain consistent effects.
• If prescribed in divided doses, take the earlier dose in the morning to reduce nighttime urination.
• Swallow tablets whole with a full glass of water.
• Do not change your dose or stop taking Aldactazide without talking to your healthcare provider.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

Aldactazide may increase sensitivity to sunlight, so using sunscreen and protective clothing may be recommended.

Because Aldactazide affects fluid and electrolyte balance, regular blood tests may be needed. Your healthcare provider may also recommend monitoring blood pressure at home.

Some mild or common side effects of Aldactazide include:

• Drowsiness or lightheadedness.
• Increased urination, especially when starting treatment.
• Headache.
• Blurred vision.
• Upset stomach or constipation.
• Muscle cramps or weakness.

Some individuals may experience serious side effects while using Aldactazide. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of electrolyte imbalance, such as irregular heartbeat, severe weakness, confusion, or fainting.
• High potassium levels, including muscle weakness or abnormal heart rhythm.
• Hypercalcemia (high calcium in the blood).
• Hyperlipidemia (high cholesterol or fats in the blood).
• Severe dehydration, with symptoms such as extreme thirst or low urine output.
• Allergic reactions, including skin rash, itching, swelling, or trouble breathing.
• Eye pain or sudden vision changes, which may be linked to glaucoma or myopia.
• Signs of kidney problems, such as swelling, reduced urination, or fatigue.
• Swelling of the breasts (gynecomastia) and breast pain.

These are not all of the possible side effects of Aldactazide. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Aldactazide, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Kidney disease or reduced kidney function.
• Liver disease, including cirrhosis.
• Addison’s disease.
• Electrolyte imbalances, such as high potassium (hypokalemia), low chloride, or low sodium.
• Diabetes or blood sugar concerns.
• Systemic lupus erythematosus.
• A history of skin cancer or sensitivity to sunlight.

Aldactazide should not be used in patients with anuria, Addison’s disease, or known hypersensitivity to spironolactone, hydrochlorothiazide, or sulfonamide-derived drugs. It is also contraindicated in patients with severe kidney impairment, where potassium levels cannot be safely controlled.

Aldactazide begins to increase urine output within hours of the first dose. Reductions in fluid retention and blood pressure may be noticed within a few days, with full effects often seen after several weeks of consistent use.

When Aldactazide is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Potassium supplements or salt substitutes can cause an increased risk of hyperkalemia (high potassium levels).
• NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen or naproxen may reduce diuretic effectiveness and affect kidney function.
• ACE inhibitors or angiotensin receptor blockers, such as captopril, enalapril, lisinopril, and losartan, which can increase potassium levels.
• Lithium, which may reach toxic levels when combined with diuretics.
• Digoxin, as electrolyte changes may increase the risk of toxicity.
• Cholestyramine may reduce the absorption of hydrochlorothiazide.
• Corticosteroids such as prednisone, methylprednisolone, or dexamethasone.
• Eplerenone.
• Triamterene.
• Abiraterone.
• Amiloride.

Aldactazide tablets are available in different fixed-dose combinations of spironolactone and hydrochlorothiazide. Your healthcare provider will choose the dose based on your condition, response, and electrolyte levels.

Aldactazide should be stored at room temperature, away from the reach of children or pets.

Aldactazide is manufactured by Pfizer.

Yes. Aldactazide is available in generic form as spironolactone and hydrochlorothiazide tablets.

Do not stop taking Aldactazide without speaking to your healthcare provider. Stopping suddenly may lead to worsening fluid retention or increased blood pressure. Your provider may gradually adjust your dose or recommend an alternative treatment.

Aldactazide is generally not recommended during pregnancy, as it may affect the developing baby. Your healthcare provider will help decide the safest option.

Both spironolactone and hydrochlorothiazide may pass into breast milk. Your healthcare provider will weigh the benefits and potential risks before recommending use.