Auvi-Q

(Epinephrine)

The active ingredient in Auvi-Q is epinephrine, which is used to rapidly reverse serious allergic reactions (anaphylaxis). Epinephrine stimulates alpha and beta-adrenergic receptors, causing blood vessels to constrict, which raises blood pressure and reduces swelling, while also relaxing airway muscles to improve breathing. At the same time, it helps stop further release of allergy-causing chemicals from immune cells.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Auvi-Q. However, the following is a synopsis of the general guidelines for the use of Auvi-Q:

• Auvi-Q is an auto-injector intended for injection into the outer thigh.
• It can be injected through clothing if needed.
• Each device is for single use only.
• Remove the red safety guard before use.
• Place the black end firmly against the outer thigh and follow the voice instructions.
• Hold the device in place until the countdown and voice prompt indicate the injection is complete.
• After injecting a dose, you or someone else should call 911 or go to the nearest emergency room.
• A second dose may be needed if symptoms continue or return, as directed by a healthcare provider.
• Caregivers should be trained on proper use before an emergency occurs.
• Check the viewing window regularly to ensure the solution is clear and colorless.
• Always carry Auvi-Q with you if you are at risk of severe allergic reactions.

Some mild or common side effects of Auvi-Q include:

• Increased heart rate.
• Nervousness or anxiety.
• Shaking or tremor.
• Headache.
• Dizziness.
• Sweating.
• Nausea.
• Weakness.
• Injection site reactions.

Some individuals may experience serious side effects while using Auvi-Q. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Chest pain or irregular heartbeat.
• Severe increase in blood pressure.
• Trouble breathing that does not improve.
• Signs of heart problems, such as shortness of breath or fainting.
• Accidental injection into the hands or feet causes numbness, pain, or color changes.

These are not all of the possible side effects of Auvi-Q. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Auvi-Q, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart disease or heart rhythm problems.
• High blood pressure.
• Thyroid problems.
• Parkinson’s disease.
• Diabetes.
• A history of depression or other mental health conditions.
• Narrow-angle glaucoma.
• Sensitivity to epinephrine.
• A history of allergic reactions requiring emergency treatment.

There are no absolute contraindications to the use of Auvi-Q in an allergic emergency. Epinephrine is the preferred and life-saving treatment for anaphylaxis.

Auvi-Q begins working within minutes of injection. It acts quickly to reduce symptoms such as trouble breathing, swelling, hives, and low blood pressure. Emergency medical care is still required after use.

When Auvi-Q is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Tricyclic antidepressants, which may increase the effects of epinephrine.
• Monoamine oxidase inhibitors, which may increase your blood pressure.
• Beta-blockers, which may reduce the effectiveness of epinephrine.
• Cardiac glycosides, which may increase the risk of heart rhythm problems.
• Diuretics, which may increase the risk of irregular heartbeat.

Auvi-Q is available in multiple dose strengths based on body weight:

0.1 mg for patients weighing 7.5 kg to less than 15 kg.

0.15 mg for patients weighing 15 kg to less than 30 kg.

0.3 mg for patients weighing 30 kg or more.

It should be stored at room temperature, away from the reach of children or pets.

Auvi-Q is manufactured by Kaleo.

No, there is no generic version of Auvi-Q available.

Auvi-Q is used only during an allergic emergency. There is no routine dosing schedule to stop. Always replace the device after use and before the expiration date.

Epinephrine may be used during pregnancy when needed to treat a severe allergic reaction. Prompt treatment of anaphylaxis is critical. Discuss risks and benefits with your healthcare provider.

Auvi-Q can be used during breastfeeding when medically necessary. Epinephrine is rapidly broken down in the body. Breastfeeding does not need to be stopped after use.