Epipen

The active ingredient in brand-name EpiPen is epinephrine (adrenalin). It acts on beta and alpha-adrenergic receptors that are located all around your body. Epinephrine attaches to these receptors that have multiple functions, and in turn creates the effects that counter those of anaphylaxis, such as raising your heart rate, relaxing your muscles and airways, stabilizing blood pressure, and opening your airways. With the use of an EpiPen, you will be able to breathe more normally.

EpiPen treats the symptoms of a range of severe allergies. These severe allergies happen to people who are exposed to what is usually a harmless substance but causes an anaphylactic shock in certain people. These are called an allergy trigger (allergens). The most common allergens are:

• Food allergies
• Medications
• Insect bites and stings
• Exercise
• Latex
• Unknown causes

Anaphylactic reactions can look like:

• Hives
• Trouble breathing
• Itchy skin
• Raised, red skin rash
• Wheezing
• Abdominal pain, nausea and vomiting
• Swelling of the mouth

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, Medication Guide, and any additional information provided before using EpiPen. However, the following is a synopsis of the general guidelines for the use of EpiPen:

It is recommended that you carry two EpiPens and/or two EpiPen Jr auto-injectors with you at all times. Often a single dose injection is not enough for a severe allergic reaction (a second dose is required in about 15-36% of patients).

Regular inspection of the EpiPen solution is crucial. The solution should always be clear. If discoloration, solid particles, signs of leakage, it is past the expiration date, or damage to the carrier is noticed, it is recommended to replace the EpiPen Auto-Injector. Proper disposal of used, expired, or discolored EpiPen Auto-Injectors is important. It is advised not to dismantle the auto-injector and to consult a pharmacist or physician for proper disposal methods. Expiration reminders are available, and it is highly recommended to register for EpiPen expiration reminders to ensure the availability of a functioning device at all times.

An EpiPen is given through an intramuscular injection, which is preferred over subcutaneous administration due to the speed at which the medicine filters through your body. When you need to use it, using an EpiPen is a pretty straightforward process. After removing the auto-injector from its carrier tube, you hold it with the orange tip pointing downward. Remove the blue safety release by pulling it straight up. Place the orange tip against the middle of the outer thigh at a right angle to the thigh. Swing and firmly push the auto-injector into the thigh until it clicks. Hold it in place for three seconds and then massage the injection area for 10 seconds. Seek immediate medical help by going to the emergency room. You must receive emergency treatment after injecting yourself with EpiPen.

If you are a caregiver and need to inject a young child, make sure that you hold their leg firmly in place both before and while the 3-second injection is happening to prevent any injuries. Then seek immediate medical care.

The most common side effects of EpiPen include:

• Restlessness
• Anxiety
• Dizziness
• Weakness
• Tremor
• Nausea/Vomiting
• Sweating
• Pounding heart
• Headache
• Pale appearance

Some individuals may experience serious side effects while using EpiPen. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Arrhythmias (irregular heart rhythm)
• Skin infections
• Injection site reactions
• Increased blood pressure and heart rate

These are not all of the possible side effects of EpiPen. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting EpiPen, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart problems, such as heart disease or high blood pressure
• Diabetes
• Thyroid issues
• Asthma
• Depression history
• Parkinson's disease
• A pregnancy, breastfeeding, or plans to become pregnant.

There are no contraindications to the use of epinephrine in a life-threatening situation.

EpiPen works quickly, typically within minutes, to reverse the symptoms of a severe allergic reaction. The effects of epinephrine can last for 10 to 20 minutes, but you may need further medical treatment after using the EpiPen. Immediate medical attention is crucial, even if symptoms improve, to ensure proper care and monitoring.

When EpiPen is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Diuretics and cardiac glycosides
• Patients should be observed in the case of cardiac arrhythmias
• Tricyclic antidepressants, levothyroxine sodium, monoamine oxidase inhibitors, and certain antihistamines
• The effects of EpiPen may be increased.
• Beta-adrenergic blocking drugs (Ex: propranolol)
• Alpha-adrenergic blocking drugs (ex: phentolamine)
• Ergot alkaloids

EpiPen is available in two dosages: 0.15 mg (EpiPen Jr) and 0.3 mg. Your healthcare provider will determine the dose of epinephrine based on your specific needs and medical history.

EpiPen comes in several different forms including EpiPen, EpiPen 2-Pak, Epipen Jr, EpiPen Jr 2-Pak, and more. A healthcare professional will also assess whether you will need one or more of these products, a different form of epinephrine, antihistamines, steroids, or any other treatments that are necessary for your condition.

EpiPens should be stored at room temperature, between 68°F and 77°F (20°C to 25°C), and kept away from extreme heat, cold, and sunlight. Do not refrigerate or freeze the EpiPen, as it may damage the device. Keep it in its carrying case to protect it from damage and ensure it is always accessible in an emergency.

Both EpiPen and EpiPen Jr are manufactured by Mylan, inc.

Yes, an authorized generic version of an EpiPen is available.

You do not need to "stop" using an EpiPen, as it is intended for emergency use only during severe allergic reactions. Once an EpiPen is used, seek immediate medical attention, and your healthcare provider will guide you on further treatment. If you no longer need it, your doctor may adjust your allergy management plan, but they will likely recommend that you always have one available in case of a future emergency.

Evidence shows that it is okay to use an EpiPen while pregnant, as the benefits outweigh the risks. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Epinephrine is not known to be absorbed into milk, so the evidence suggests that it’s okay to use an EpiPen while breastfeeding. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.