DDAVP

(Desmopressin Acetate)

The active ingredient in DDAVP oral tablets is desmopressin, a synthetic form of the antidiuretic hormone vasopressin. Its mechanism of action includes reducing the amount of urine produced by the kidneys, helping control excessive urination and thirst in central diabetes insipidus, and supporting nighttime urine control in nocturnal enuresis.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labelling, Instructions for Use, and Medication Guide before using DDAVP. However, the following is a synopsis of the general guidelines for the use of desmopressin:

Fluid intake must be limited from one hour before taking desmopressin tablets and until at least eight hours after the dose to reduce the risk of water retention and low sodium levels.

If you miss a dose, take it as soon as possible and then go back to your regular dosing schedule, but if it is almost time for your next dose, skip the missed dose and do not double-dose.

This medication should not be used if you have a fever, are vomiting, have diarrhea, or are severely dehydrated.

This medication may cause low levels of sodium in your blood, and you will need regular bloodwork to monitor your serum sodium.

Some mild or common side effects of DDAVP include:

Headache.

Nausea.

Nasal congestion.

Runny nose (rhinitis).

Some individuals may experience serious side effects while using DDAVP. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

Hyponatremia (low blood sodium) may cause muscle weakness, confusion, severe headache, nausea, sudden weight gain, vomiting, or convulsions.

Water intoxication due to excessive fluid retention.

Severe allergic reactions, including swelling, rash, hives, wheezing, or anaphylaxis.

These are not all of the possible side effects of DDAVP. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting DDAVP, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

Pregnancy or breastfeeding.

Conditions associated with fluid or electrolyte imbalance, such as vomiting, diarrhea, or severe dehydration.

Fever.

Bleeding problems.

Low sodium levels or a history of hyponatremia.

Heart failure, liver or kidney disease, or high blood pressure (hypertension).

Cystic fibrosis or conditions associated with increased fluid intake.

Lactose intolerance.

Hyponatremia or a history of low sodium levels.

Eating disorders such as bulimia or anorexia.

Adrenal problems such as Addison’s disease.

Bleeding problems such as Type II B or platelet-type (pseudo) Von Willebrand’s disease.

Any heart, liver, or renal impairment.

Known hypersensitivity or allergy to desmopressin.

DDAVP tablets begin working after absorption and can reduce urine output as the medication takes effect. Your provider may monitor urine volume and urine osmolality to assess response.

When DDAVP is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

Medications which may put you at an increased risk of hyponatremia or water intoxication: tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), carbamazepine, lamotrigine, chlorpropamide, chlorpromazine, clofibrate, diuretics (including furosemide), loperamide, and Nonsteroidal anti-inflammatory drugs (NSAIDs).

Medications that may reduce the effectiveness of DDAVP: demeclocycline, norepinephrine, and lithium.

It is available in tablets containing 0.1 mg or 0.2 mg of desmopressin.

It should be stored at room temperature, away from the reach of children or pets.

It is manufactured by Ferring Pharmaceuticals.

Yes, it is available from many manufacturers of generic drugs. It is also available in other dosage forms and formulations, such as a nasal spray or oral dissolving tablet.

Do not stop taking DDAVP without speaking to your healthcare provider. Stopping suddenly may cause your symptoms to return.

There are no controlled studies in pregnant women. DDAVP tablets should only be used if your healthcare provider determines it is needed.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Small amounts of desmopressin may pass into breast milk, but the amounts are considerably less than those required to influence urination in the child.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.