Endometrin

The active ingredient in Endometrin is progesterone micronized. Endometrin (progesterone) contains progesterone, which is a necessary hormone for pregnancy. Progesterone prepares the uterus to accept and feed embryos. This medication belongs to a progesterone drug class.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Endometrin. However, the following is a synopsis of the general guidelines for the use of Endometrin:

• Do not take by mouth. Endometrin is solely for use in the vagina.
• Use the provided applicator to insert this drug directly into the vagina. Use a disposable applicator only once and then discard it.
• Read all of the patient information, prescription guidelines, and instruction sheets that were sent to you. If you have any questions, ask your doctor or chemist.
• If this medication makes you dizzy or drowsy, take it before going to bed.
• Endometrin 100 mg is put into the vagina two or three times daily beginning the day after egg (oocyte) retrieval and lasting up to ten weeks.
• The effectiveness in women aged 35 and up has not been convincingly proven. The optimum Endometrin dose for this age group has not been identified.
• While using progesterone vaginally, get regular medical checks and self-examine your breasts for lumps once a month.
• If you require surgery or medical testing, or if you will be on bed rest, you may need to discontinue using this medication for a brief period of time. Any doctor or surgeon who treats you should be aware that you use Endometrin.

Some mild and common side effects of Endometrin seen in clinical trials as compared to placebo include:

• Stomach pain.
• Ovarian hyperstimulation syndrome (swollen ovaries).
• Stomach bloating.
• Vomiting.
• Constipation.
• Fatigue.
• Severe headache.
• Vaginal irritation.
• Vaginal burning.
• Vaginal discharge.
• Mood swings.
• Pain after egg retrieval, such as pelvic pain and stomach cramps.

Some individuals may experience serious side effects while using Endometrin. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Blood clots can cause persistent lower leg pain, shortness of breath, coughing up blood, and sudden vision loss.
• Heart attack symptoms include chest pain or tightness, as well as pain radiating to your shoulder, arm, neck, or jaw.
• Stroke symptoms include difficulty speaking or walking, numbness on one side of the body or face, and intense headaches that occur suddenly.
• Abnormal vaginal bleeding.
• Allergic reaction to the medication, such as hives, skin rash, or swelling.

These are not all of the possible side effects of Endometrin. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Endometrin, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• A history of stroke, blood clots, or circulatory issues.
• Breast or uterine cancer.
• Abnormal vaginal bleeding.
• Liver illness.
• If you have recently experienced a tubal pregnancy (IVF - in vitro fertilization) or an incomplete or "missed" abortion.
• High blood pressure, cardiovascular illness, and congestive heart failure.
• Migraines.
• Asthma.
• Kidney disease.
• Seizures or epilepsy.
• A history of depression.
• Risk factors for coronary artery disease include diabetes, lupus, high cholesterol, a family history of the disease, smoking, and being overweight.

• Abnormal vaginal bleeding that has not been evaluated by a medical professional.
• Recognised missed abortion or ectopic pregnancy.
• Liver problems.
• Known or suspected breast or genital cancer.
• You now have or have had a blood clot.
• Allergy to other progesterone products.

Endometrin (progesterone vaginal insert) works fast after application since progesterone is absorbed directly through the vaginal tissue. However, the clinical benefit varies depending on why it is prescribed. For fertility treatments or IVF support, it immediately begins preparing the uterine lining, although the advantages are measured over several days to weeks as part of the treatment cycle.

When Endometrin is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

There are no serious interactions with this medication. However, it is still best to speak to your healthcare provider.

Each vaginal insert contains 100 milligrams of progesterone.

The usual dose is one insert inserted in your vagina two to three times each day. Endometrin (progesterone) is commonly started after egg retrieval and continued for up to ten weeks.

Make sure to follow your fertility specialist's recommendations because how and when you take Endometrin (progesterone) will vary based on your fertility treatment.

Store at room temperature and keep out of reach of children.

Ferring Pharmaceuticals is the company that manufactures Endometrin.

There are no generic name versions available of Endometrin.

You should not discontinue using Endometrin (progesterone vaginal insert) on your own. If it is taken for fertility treatment or IVF assistance, stopping too soon may harm the uterine lining and diminish the chances of a successful pregnancy.

If you are pregnant, do not use Endometrin unless it is part of your fertility treatment.

This medication can pass through the breast milk and may harm the baby.