Amjevita vs Humira: Understanding the Key Differences
In This Article What Are Amjevita and Humira? The Main Difference: Biosimilar ...
Humira (adalimumab) is a medication that helps to control and regulate an overactive immune system in various autoimmune conditions. It is commonly used in the treatment of rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis (PsA), plaque psoriasis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, moderate to severe hidradenitis suppurativa, and uveitis (including panuveitis). Humira is an injection that is typically given every other week.
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The active ingredient in Humira is the monoclonal antibody adalimumab. Adalimumab belongs to a class of medications known as TNF blockers or tumor necrosis factor blockers. TNF plays an important role in the body by activating our immune system in response to infection or injury. Although it serves a protective role, it can lead to damage when it fails to shut down in the absence of infection or injury, as seen in autoimmune conditions.
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Humira. However, the following is a synopsis of the general guidelines for the use of Humira:
The most common side effects of Humira seen in clinical trials include:
Some individuals may experience serious side effects while using Humira. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
These are not all of the possible side effects of Humira. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
Before starting Humira, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:
Boxed Warning
There are no contraindications to using Humira.
Humira does take some time to work. Depending on what you are using Humira for, it may take several weeks to see the benefits. For some people, it can take several months to get the full effects of this medication.
When Humira is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
Humira is available as a single dose in either prefilled pens or prefilled syringes.
Humira prefilled pens are available in the following strengths:
Humira prefilled syringes are available in the following strengths:
Humira should be stored in the fridge away from heat and in its original packaging to protect from light. Do not freeze Humira. Do not use it if it has thawed after being frozen. If necessary, Humira can be kept at room temperature for up to 14 days. If it is past 14 days or past the expiration date, do not use it and properly dispose of it. Keep out of reach of children.
Humira is manufactured by the pharmaceutical company AbbVie.
Since Humira is a biologic, there is no generic version of Humira. There are, however, biosimilars available of Humira that are very similar to Humira but not an exact copy. Consult your healthcare provider on which option would be best for you.
Because Humira is used for chronic autoimmune conditions where stopping may result in relapse, it is important you consult your doctor or pharmacist before starting, stopping, or changing medications while taking Humira.
Humira can cross the placenta and reach the unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Humira can pass into breast milk, but there are no reports of adverse effects on breastfed infants and no effects on milk production. However, talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
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In This Article What Are Amjevita and Humira? The Main Difference: Biosimilar ...
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Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Jamie Winn, PharmD, is a licensed pharmacist and seasoned medical content reviewer with over 20 years of experience in clinical pharmacy, patient care, and healthcare leadership.
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Shirley is a Medical Writer and first-year Doctor of Pharmacy (PharmD) student at the University of Alberta, where she is building on her strong foundation in health sciences and patient care.
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