Lozol

(Indapamide)

The active ingredient in Lozol is indapamide, which belongs to a drug class called thiazide-like diuretics. It helps the kidneys remove extra water and salt from the body. This reduces fluid retention and helps lower blood pressure by decreasing the volume of fluid in the blood vessels. Lozol is also known as a “water pill.”

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Lozol. However, the following is a synopsis of the general guidelines for the use of Lozol:

• Take Lozol exactly as prescribed by your healthcare provider. It is usually taken once daily, preferably in the morning. Swallow the tablet with water.
• Take Lozol at the same time each day to help maintain consistent blood levels.
• If you miss a dose, take it as soon as you remember. Skip the missed dose if it is close to the time of your next dose. Do not take two doses at the same time. Ask your healthcare provider for medical advice if you are unsure what to do.
• Elderly patients may be more sensitive to the effects of indapamide.

Some mild or common side effects of Lozol include:

• Dizziness or lightheadedness.
• Headache.
• Dry mouth.
• Constipation.
• Muscle pain or muscle cramps.
• Back pain.
• Drowsiness.
• Increased uric acid levels.

Some individuals may experience serious side effects while using Lozol. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Very low blood pressure (hypotension) or fainting.
• Chest pain or irregular heartbeat.
• Severe electrolyte imbalance, including low potassium levels.
• Severe muscle weakness or severe muscle cramps.
• Blurred vision or eye pain.
• Signs of an allergic reaction, such as hives, rash, or swelling.
• Symptoms of liver problems, including jaundice.
• High blood sugar or signs of hyperglycemia.

These are not all of the possible side effects of Lozol. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Lozol, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Kidney disease or reduced kidney function.
• Liver disease or hepatic impairment.
• Electrolyte imbalances, including hypokalemia.
• A history of gout or high uric acid levels.
• Diabetes or high blood sugar.
• Heart rhythm problems.
• A sulfonamide allergy.
• A history of low blood pressure.
• Conditions that cause dehydration or fluid loss.

• Known hypersensitivity to indapamide or sulfonamides.
• Severe kidney disease with little or no urine output.
• Severe liver disease or hepatic encephalopathy.
• Certain electrolyte imbalances are not corrected.

Blood pressure-lowering effects may begin within the first week of treatment, and full blood pressure control may take several weeks. Consistent daily use is important for long-term treatment of hypertension.

When Lozol is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Lithium may increase lithium levels and toxicity.
• Other antihypertensive drugs may increase the risk of low blood pressure.
• Corticosteroids may worsen electrolyte imbalance.
• Laxatives may increase potassium loss.
• Calcium supplements may increase calcium levels.
• Medications that affect heart rhythm may increase irregular heartbeat.

Lozol has been discontinued; however, the generic version is available. Indapamide is available as 1.25 mg tablets and 2.5 mg tablets. The daily dose is determined by your healthcare provider based on your blood pressure response and overall health.

It should be stored at room temperature, away from the reach of children or pets.

Lozol has been discontinued.

Yes. Indapamide is available as a generic medication. Lozol is the brand-name version of indapamide.

Do not stop taking Lozol without medical advice because stopping suddenly may cause blood pressure to rise. Your healthcare provider may gradually adjust your treatment plan.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Lozol is generally not recommended during pregnancy unless clearly needed. Your healthcare provider will decide what is best for you.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Lozol may pass into breast milk, and your healthcare provider will determine whether you should continue breastfeeding or use an alternative treatment.