Hygroton

(Chlorthalidone)

The active ingredient in Hygroton is chlorthalidone. It works by acting on the kidneys to increase the amount of urine produced. This helps remove excess sodium and water from the body, which reduces fluid retention. By decreasing the volume of fluid in blood vessels, Hygroton reduces the workload on the heart and helps control hypertension. Changes in electrolyte levels, such as sodium, potassium, calcium, and magnesium, can occur and are monitored during treatment.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Hygroton. However, the following is a synopsis of the general guidelines for the use of Hygroton:

Hygroton is taken by mouth as a tablet.

It is usually taken once daily, preferably in the morning, to reduce nighttime urination.

It may be taken with or without food.

Take the medication at the same time each day. If you miss a dose, take it as soon as you remember, unless it is close to your next dose. Do not take two doses at the same time.

Some mild or common side effects of Hygroton include:

Increased amount of urine.

Light-headedness or dizziness.

Dry mouth.

Constipation.

Loss of appetite.

Weight loss.

Some individuals may experience serious side effects while using Hygroton. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

Severe allergic reaction, including hives, swelling of the face, or difficulty breathing.

Low blood pressure with fainting.

Electrolyte imbalances, such as hypokalemia or hyponatremia, may cause muscle spasms, weakness, or irregular heartbeat.

Pancreatitis.

Severe skin rash or photosensitivity reactions, including sunburn after minimal sun exposure.

These are not all of the possible side effects of Hygroton. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Hygroton, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

Kidney disease or kidney problems.

Liver disease.

Diabetes or blood sugar problems.

High cholesterol or triglycerides.

A history of allergic reactions to sulfonamide-derived drugs.

Hygroton is contraindicated in patients with:

Known hypersensitivity to chlorthalidone or other thiazide diuretics.

Pregnant or breastfeeding patients.

Patients with anuria, severe renal failure, or severe hepatic failure.

Electrolyte abnormalities such as hypokalemia, hyponatremia, hypercalcemia, and hyperuricemia (history of gout).

Untreated Addison’s disease and concomitant lithium therapy.

Hygroton begins working within a few hours of the first dose by increasing urine output. Blood pressure-lowering effects may be seen within several days, with full benefit often achieved after a few weeks of consistent use.

When Hygroton is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

ACE inhibitors may increase the risk of low blood pressure when used together.

Alcohol, barbiturates, and narcotics may increase dizziness when taken while on Hygroton.

Use of thiazide diuretics may reduce renal excretion of cytotoxic agents such as cyclophosphamide or methotrexate and increase their effectiveness.

Thiazide diuretics may cause high blood pressure and prevent insulin and oral antidiabetics from working effectively.

NSAIDs and other anti-inflammatory drugs, which may reduce the blood pressure-lowering effect of Hygroton and impair kidney function.

Digitalis or digoxin, where low potassium levels may increase the risk of toxicity.

Steroids may increase the risk of electrolyte imbalance.

It is available in 50mg tablets.

It should be stored at room temperature, in a dry place, away from the reach of children or pets.

Brand-name Hygroton is no longer marketed, but chlorthalidone is available from many manufacturers of generic drugs.

Yes, it is available from many manufacturers of generic drugs.

Do not stop taking Hygroton without medical advice. Stopping treatment suddenly may cause blood pressure or fluid retention to worsen. Your healthcare provider will advise if dose changes or discontinuation are needed.

Hygroton should be used during pregnancy only if clearly needed. Talk to your healthcare provider if you are pregnant or planning to become pregnant.

Chlorthalidone passes into breast milk and may reduce milk production. Talk to your healthcare provider if you are breastfeeding or planning to breastfeed so they can help determine the best option.