Macrobid

The active ingredient in Macrobid is nitrofurantoin. The mechanism of action by which nitrofurantoin kills bacteria involves inhibiting many key processes vital to the bacteria’s survival including energy production, DNA synthesis, and protein formation. Its activity is limited to the urinary tract making it a good choice for cystitis or acute uncomplicated urinary tract infections. It has good activity against Escherichia coli which is the most common bacteria behind this type of infection.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Macrobid. However, the following is a synopsis of the general guidelines for the use of Macrobid:

• Macrobid is typically taken by mouth twice a day with food. Taking with food will minimize stomach upset.
• The duration of treatment will depend on your medical history and the severity of the infection.
• Macrobid should be used exactly as prescribed. Do not stop the course of treatment if you start to feel better unless directed by your healthcare provider. Missed doses may contribute to bacterial resistance and result in decreased efficacy of the medication and the infection coming back.
• Macrobid does not work for viral infections. Like other antibacterial agents, the use of nitrofurantoin is limited to bacterial infections.
• Macrobid can be used in pediatric patients but only in those 12 years of age and older.
• If your infection worsens or does not get better after completing a course of Macrobid, follow up with your healthcare provide

The most common side effects of Macrobid include:

• Nausea
• Headache
• Dizziness
• Gas
• Stomach upset
• Abdominal pain
• Indigestion
• Drowsiness
• Numbness or tingling sensation

Some individuals may experience serious side effects while using Macrobid. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of lung disease such as chest pain, shortness of breath, fever, chills, or cough that doesn’t go away.
• Signs of liver problems or hepatotoxicity like jaundice or yellowing of the skin or eyes, loss of appetite, or dark urine.
• Vision changes that could be a sign of optic neuritis.
• Frequent bloody and watery stools during or months after using Macrobid. This could be a sign of C. difficile-associated diarrhea, an infection that requires prompt medical attention.
• Signs of an allergic reaction such as trouble breathing, hives, rash, or swelling of the face, tongue, or eyes.

These are not all of the possible side effects of Macrobid. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Macrobid, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Lung disease
• Hepatic impairment or liver problems
• Decreased renal function or kidney disease
• Deficiency of G6PD enzyme in the red blood cells (glucose-6-phosphate dehydrogenase)
• Peripheral neuropathy
• Anemia
• Diabetes mellitus
• Electrolyte imbalances
• Vitamin B deficiency
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

Do not use Macrobid if you have:

• Severe renal impairment
• Cholestatic jaundice
• Liver disease
• Are in the final stages of your pregnancy (3rd trimester or at delivery). There is an increased risk for hemolytic anemia in the baby.
• An allergy to nitrofurantoin or any of the other ingredients found in Macrobid

Macrobid will start to work against the infection right after the first dose. However, depending on the type of infection and the severity, you may not notice the effects until after a few days of regular use.

When Macrobid is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Antacids with magnesium trisilicate
• Probenecid
• Sulfinpyrazone

Macrobid capsules are available in the following strengths:

• 100 mg (25 mg nitrofurantoin macrocrystals + 75 mg nitrofurantoin monohydrate)

Nitrofurantoin may also be available in other formulations under other brand names like Macrodantin or Furadantin.

Macrobid should be stored at room temperature away from light and out of reach of children.

Macrobid is manufactured by the pharmaceutical company Almatica Pharma.

Yes, a generic version of Macrobid is available.

Macrobid is typically a short-term medication. Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Macrobid.

Macrobid can be harmful to you and your baby near the end of your pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Macrobid can pass into the breastmilk and can be harmful if the breastfeeding infant is less than 1 month of age. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.